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CAS No.: 5081-48-1

Ellipticine HCl/玫瑰树碱盐酸盐 Catalog No. CSN18924

Synonyms: NSC 71795 hydrochloride;NSC 71795 HCl;Ellipticine Hydrochloride

Ellipticine HCl is a potent antineoplastic agent and inhibits DNA topoisomerase II activities.

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生物活性

实验方案

技术信息

生物活性

描述Ellipticine, a natural product with antitumor activity, can intercalate into DNA and block topoisomerase II activity. Treatment with Ellipticine led to reproducibly stimulated DNA cleavage and produced predominantly DNA double-strand breaks. Ellipticine showed almost complete inhibition of kDNA decatenation catalyzed by human topoisomerase IIα at concentration of 5mM. Ellipticine exhibited dose-dependent cell viability inhibition of neuroblastoma UKF-NB-4 and SH-SY5Y at concentration ranging in 0.625-5μM at 48h post treatment, while combination with valproic acid could enhance the cytotoxicity and induce apoptosis. Also, it suggested that the bind of Ellipticine to core histone(s) in addition to DNA as a 'dual binder', and formation of covalent DNA adducts mediated by its oxidation with cytochromes P450 (CYP) and peroxidases may be another mode of ellipticine action on cytotoxicity.
动物研究
剂量
Mice: 30 mg/kg - 90 mg/kg^[3] (i.p.), 3.1 mg/kg - 25 mg/kg^[4] (i.p.); 6.2 mg/kg - 50 mg/kg^[4] (p.o.)

给药途径
i.p., p.o.
参考文献

动物研究
剂量	Mice: 30 mg/kg - 90 mg/kg^[3] (i.p.), 3.1 mg/kg - 25 mg/kg^[4] (i.p.); 6.2 mg/kg - 50 mg/kg^[4] (p.o.)
给药途径	i.p., p.o.

[1] Stiborova M, Poljakova J, et al. Ellipticine cytotoxicity to cancer cell lines - a comparative study. Interdiscip Toxicol. 2011 Jun;4(2):98-105.
[2] Stiborova M, Rupertova M, et al. Molecular mechanisms of antineoplastic action of an anticancer drug ellipticine. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2006 Jul;150(1):13-23.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.5365 mL
- 17.6824 mL
- 35.3648 mL
- 5 mM
- 0.7073 mL
- 3.5365 mL
- 7.0730 mL
- 10 mM
- 0.3536 mL
- 1.7682 mL
- 3.5365 mL

技术信息

CAS号

5081-48-1

储存条件

粉末: Inert atmosphere,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C17H15ClN2

运输

蓝冰

分子量

282.77

别名

NSC 71795 hydrochloride;NSC 71795 HCl;Ellipticine Hydrochloride;Ellipticine HCl;CCG-36483;DB-052047;K00071;LP00531;LS-133282;NSC-71795;TCMDC-125546;VZ29809;Elliptecine;Ellipticine;Elliptisine;玫瑰树碱盐酸盐;盐酸玫瑰树碱

溶解度

DMSO	39.0 mg/mL (137.9 mM)
Water	insoluble

动物实验配方

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Ellipticine HCl/玫瑰树碱盐酸盐 Catalog No. CSN18924

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