|4-羟基喹啉-2-羧酸|CsnPharm

CAS No.: 492-27-3

Empirical Formula/犬尿喹啉酸水合物 Catalog No. CSN10840

Synonyms: Quinurenic acid;NSC 58973;Kynuronic acid

Kynurenic Acid is a broad spectrum glutamatergic antagonist which can antagonize NMDA, kainate and AMPA receptors.

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技术信息

生物活性

描述Kynurenic acid (KYNA) is an endogenous antagonist of glutamate in the central nervous system. It is most active as an antagonist at receptors sensitive to N‐methyl‐D‐aspartate (NMDA) which regulate neuronal excitability and plasticity, brain development and behaviour^[3]. Peripheral administration of kynurenic acid, at a dose that caused plasma levels to increase 430-fold, resulted in only 4-fold increases in striatal ECF(extracellular fluid) concentrations^[4]. KYNA has a significant protective effect on liver injury induced by thioacetamide (TAA)^[5].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT03557684	Depression	Early Phase 1	Recruiting	July 31, 2020	United States, California ... more >> UCLA Cousins Center for Psychoneuroimmunology Recruiting Los Angeles, California, United States, 90095 Contact: Gracie Pineda 310-825-8425 grpineda@g.ucla.edu Principal Investigator: Joshua H Cho, MD, PhD Collapse <<
NCT00573300	-	-	Completed	-	United States, Massachusetts ... more >> Freedom Trail Clinic Boston, Massachusetts, United States, 02114 Collapse <<
NCT02234752	Schizophrenia ... more >> Schizoaffective Disorder Collapse <<	Phase 2	Terminated(Funding no longer a... more >>vailable and PI no longer working at the institution) Collapse <<	-	United States, Maryland ... more >> Sheppard Pratt Health System Baltimore, Maryland, United States, 21204 Collapse <<

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参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 5.2863 mL
- 26.4316 mL
- 52.8632 mL
- 5 mM
- 1.0573 mL
- 5.2863 mL
- 10.5726 mL
- 10 mM
- 0.5286 mL
- 2.6432 mL
- 5.2863 mL

技术信息

CAS号

492-27-3

储存条件

粉末: Sealed in dry,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C10H7NO3

运输

蓝冰

分子量

189.17

别名

Quinurenic acid;NSC 58973;Kynuronic acid;犬尿喹啉酸;犬尿酸

溶解度

DMSO	10.0 mg/mL (52.9 mM)
Water	Insoluble
Ethanol	Insoluble

动物实验配方

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NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT03557684	Depression	Early Phase 1	Recruiting	July 31, 2020	United States, California ... more >> UCLA Cousins Center for Psychoneuroimmunology Recruiting Los Angeles, California, United States, 90095 Contact: Gracie Pineda 310-825-8425 grpineda@g.ucla.edu Principal Investigator: Joshua H Cho, MD, PhD Collapse <<
NCT00573300	-	-	Completed	-	United States, Massachusetts ... more >> Freedom Trail Clinic Boston, Massachusetts, United States, 02114 Collapse <<
NCT02234752	Schizophrenia ... more >> Schizoaffective Disorder Collapse <<	Phase 2	Terminated(Funding no longer a... more >>vailable and PI no longer working at the institution) Collapse <<	-	United States, Maryland ... more >> Sheppard Pratt Health System Baltimore, Maryland, United States, 21204 Collapse <<
NCT03285399	-	-	Completed	-	Nepal ... more >> Siddhi Memorial Hospital (SMH),Bhelukhel, Bhimsensthan Bhaktapur, Nepal, P.O.Box 40 Collapse <<
NCT02234752	-	-	Terminated(Funding no longer a... more >>vailable and PI no longer working at the institution) Collapse <<	-	-
NCT03513822	Neuralgia Chr... more >>onic Pain Inflammation Collapse <<	Phase 3	Recruiting	November 2018	France ... more >> Raymond Poincaré Hospital Recruiting Garches, Hauts De Seine, France, 92380 Contact: Cyril QUEMENEUR, Resident 0033681193981 c.quemeneur@gmx.com Contact: Valeria Martinez, MD, PhD 0033601819222 valeria.martinez@aphp.fr Collapse <<
NCT03539835	Cancer	Not Applicable	Recruiting	September 2019	United States, Georgia ... more >> Winship Cancer Institute Recruiting Atlanta, Georgia, United States, 30322 Contact: Monica Serra, MD 404-727-6123 monica.christine.serra@emory.edu Collapse <<
NCT02992899	PostTraumatic Stress Disorder	Not Applicable	Recruiting	July 2019	United States, Georgia ... more >> Emory University Recruiting Atlanta, Georgia, United States, 30322 Contact: Stacy Ladd 404-712-2014 sladd2@emory.edu Collapse <<
NCT03125083	Skin Restricted Lupus ... more >> Psychiatric Disorders Collapse <<	Not Applicable	Recruiting	December 2018	France ... more >> CHU Clermont-Ferrand Recruiting Clermont-Ferrand, France, 63003 Contact: Patrick LACARIN 04 73 75 11 95 placarin@chu-clermontferrand.fr Principal Investigator: Isabelle JALENQUES Collapse <<
NCT01975584	Schizophrenia ... more >> Schizoaffective Disorder Collapse <<	Not Applicable	Completed	-	United States, Maryland ... more >> Maryland Psychiatric Research Center Catonsville, Maryland, United States, 21228 Collapse <<
NCT03014518	-	-	Recruiting	August 2019	United States, Ohio ... more >> The Cleveland Clinic Recruiting Cleveland, Ohio, United States, 44195 Contact: Tatiana Falcone, M.D. 216-444-7459 falcont1@ccf.org Collapse <<
NCT01304355	-	-	Unknown	January 2012	Ireland ... more >> Cork University Hospial Recruiting Cork, Ireland Contact: Gerard Clarke, PhD 00353214901415 g.clarke@ucc.ie Principal Investigator: Gerard Clarke, PhD Principal Investigator: Timothy G Dinan, Professor Principal Investigator: John F Cryan, PhD University College Cork Recruiting Cork, Ireland Contact: Gerard Clarke, PhD 00353214901415 g.clarke@ucc.ie Principal Investigator: Gerard Clarke, PhD Principal Investigator: Timothy G Dinan, Professor Principal Investigator: John F Cryan, PhD Collapse <<
NCT02067975	Schizophrenia	Phase 2 Phase 3	Recruiting	December 2018	United States, Maryland ... more >> Maryland Psychiatric Research Center Recruiting Catonsville, Maryland, United States, 21228 Principal Investigator: Robert W. Buchanan, M.D. Collapse <<
NCT02340325	Cicatrix Cica... more >>trix, Hypertrophic Keloid Collapse <<	Phase 1	Completed	-	Canada, British Columbia ... more >> BCPFF Burn & Wound Healing Lab Vancouver, British Columbia, Canada, V5Z1M9 Collapse <<
NCT03583554	Healthy	Phase 1 Phase 2	Recruiting	March 31, 2019	United States, Texas ... more >> Michael E. DeBakey VA Medical Center Recruiting Houston, Texas, United States, 77030 Contact: Marijn Lijffijt, PhD 713-798-5642 marijn.lijffijt@bcm.edu Sub-Investigator: Sanjay J. Mathew, MD Sub-Investigator: Alan C. Swann, MD Collapse <<
NCT01558570	-	-	Completed	-	United States, Maryland ... more >> Maryland Psychiatric Research Center Catonsville, Maryland, United States, 21228 Collapse <<

Empirical Formula/犬尿喹啉酸水合物 Catalog No. CSN10840

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