|4-(1-(4-(2-(甲氨基)乙氧基)苯基)-2-苯基丁-1-烯基)苯酚|CsnPharm

CAS No.: 110025-28-0

Endoxifen/因多昔芬 Catalog No. CSN27370

Synonyms: (E/Z)-Endoxifen;(E/Z)-N-desmethyl-4-hydroxy Tamoxifen;(Z/E)-Endoxifen

Endoxifen is a key active metabolite of tamoxifen (TAM) with higher affinity and specificity to estrogen receptor that also inhibits aromatase activity.

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描述The estrogen receptor (ER) is not only a powerful predictive and prognostic marker, but also an efficient target for the treatment of hormone-dependent breast cancer with antiestrogens^[4]. Endoxifen is a potent antiestrogen that functions in part by targeting ERα for degradation by the proteasome in breast cancer cells^[5]. Treatment of B16F10 mouse and SK-MEL-5 human melanoma cell lines with 10 μM of endoxifen for 48 h respectively resulted in 93.6 and 92.5% cell death. Orally administered endoxifen, at dose levels of 4 and 8 mg/kg body weight/day for 20 consecutive days, respectively reduced metastatic melanoma nodules in the lungs of B16F10 cell-bearing C57BL/6 mice by 26.7 and 82.7%^[6]. Oral endoxifen administration once a day for 28 consecutive days at dosages 2, 4, and 8 mg/kg proved safe and resulted in progressive inhibition of the growth of the human mammary tumor xenografts in female mice making endoxifen a potentially new therapeutic agent for breast cancer^[7].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.6775 mL
- 13.3873 mL
- 26.7747 mL
- 5 mM
- 0.5355 mL
- 2.6775 mL
- 5.3549 mL
- 10 mM
- 0.2677 mL
- 1.3387 mL
- 2.6775 mL

技术信息

CAS号	110025-28-0	储存条件	粉末 Keep in dark place,Sealed in dry,Room Temperature 液体 -20°C:3-6 月 -80°C:12月
分子式	C25H27NO2	运输	蓝冰
分子量	373.49	别名	(E/Z)-Endoxifen;(E/Z)-N-desmethyl-4-hydroxy Tamoxifen;(Z/E)-Endoxifen

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Endoxifen/因多昔芬 Catalog No. CSN27370

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