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CAS No.: 1032008-74-4

Endoxifen Z-isomer HCl/Z-因多昔芬盐酸盐 Catalog No. CSN17408

Synonyms: Endoxifen HCl;Endoxifen hydrochloride;Z-Endoxifen HCl

Endoxifen Z-isomer HCl is the most important Tamoxifen metabolite responsible for eliciting the anti-estrogenic effects of this drug in breast cancer cells expressing estrogen receptor-alpha (ERα). Endoxifen Z-isomer HCl inhibits hERG tail currents at 50 mV in a concentration-dependent manner with IC50 values of 1.6 μM.

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技术信息

生物活性

描述Endoxifen Z-isomer hydrochloride is the most important Tamoxifen metabolite responsible for eliciting the anti-estrogenic effects of this drug in breast cancer cells expressing estrogen receptor-alpha (ERα). Endoxifen Z-isomer hydrochloride inhibits hERG tail currents at 50 mV in a concentration-dependent manner with IC50 values of 1.6 μM.
细胞研究

Cell Data

Cell Lines	Concentration	Assay Type	Time	Activity Description	Data Sources
MCF7 cells	10 uM	Function assay	6 h	Upregulation of ERalpha protein levels in human MCF7 cells at 10 uM after 6 hrs by Western blot method	24332630
MCF7:WS8 cells	-	Function assay	48 h	Agonist activity at ER in human MCF7:WS8 cells assessed as GREB1 gene expression at 10'-6 M after 48 hrs by RT-PCR analysis	24805199

参考文献

[1] Chae YJ, Lee KJ, et al. Endoxifen, the active metabolite of tamoxifen, inhibits cloned hERG potassium channels. Eur J Pharmacol. 2015 Apr 5;752:1-7.
[2] Wu X, Subramaniam M, et al. Estrogen receptor-beta sensitizes breast cancer cells to the anti-estrogenic actions of endoxifen. Breast Cancer Res. 2011 Mar 10;13(2):R27.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.4393 mL
- 12.1967 mL
- 24.3933 mL
- 5 mM
- 0.4879 mL
- 2.4393 mL
- 4.8787 mL
- 10 mM
- 0.2439 mL
- 1.2197 mL
- 2.4393 mL

技术信息

CAS号	1032008-74-4	储存条件	粉末 Inert atmosphere,2-8°C 液体 -20°C:3-6 月 -80°C:12月
分子式	C25H28ClNO2	运输	蓝冰
分子量	409.95	别名	Endoxifen HCl;Endoxifen hydrochloride;Z-Endoxifen HCl;4-Hydroxy-N-desmethyltamoxifen;N-Desmethyl-4-hydroxytamoxifen;Z-因多昔芬盐酸盐

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Endoxifen Z-isomer HCl/Z-因多昔芬盐酸盐 Catalog No. CSN17408

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