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CAS No.: 934353-76-1

ENMD-2076 Catalog No. CSN18598

Synonyms: Enmd-2076

ENMD-2076 has selective activity against Aurora A and Flt3 with IC50 of 14 nM and 1.86 nM, 25-fold selective for Aurora A than over Aurora B and less potent to VEGFR2/KDR and VEGFR3, FGFR1 and FGFR2 and PDGFRα.

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靶点选择性

生物活性

实验方案

技术信息

生物活性

描述ENMD-2076 has selective activity against Aurora A and Flt3 with IC50 of 14 nM and 1.86 nM, 25-fold selective for Aurora A than over Aurora B and less potent to VEGFR2/KDR and VEGFR3, FGFR1 and FGFR2 and PDGFRα.
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT00806065	Multiple Myeloma	Phase 1	Completed	-	United States, Indiana ... more >> Indiana University Melvin and Bren Simon Cancer Center Indianapolis, Indiana, United States, 46202 Collapse <<
NCT00658671	Advanced Cancer	Phase 1	Completed	-	United States, Colorado ... more >> University of Colorado Hospital Aurora, Colorado, United States, 80045 United States, Massachusetts Dana Farber/Harvard Cancer Center Boston, Massachusetts, United States Collapse <<
NCT01104675	Ovarian Cancer ... more >> Fallopian Cancer Peritoneal Cancer Collapse <<	Phase 2	Completed	-	United States, Colorado ... more >> University of Colorado Cancer Center Aurora, Colorado, United States, 80045 United States, Illinois University of Chicago Medical Center Chicago, Illinois, United States, 60637 United States, Indiana Indiana University Simon Cancer Center Indianapolis, Indiana, United States, 46202 United States, Massachusetts Dana Farber/Partners Cancer Care Boston, Massachusetts, United States, 02115 United States, New York Memorial Sloan-Kettering Cancer Center New York, New York, United States Canada, Ontario Princess Margaret Hospital Toronto, Ontario, Canada Collapse <<

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参考文献

[1] Fletcher GC, Brokx RD, et al. ENMD-2076 is an orally active kinase inhibitor with antiangiogenic and antiproliferative mechanisms of action. Mol Cancer Ther. 2011 Jan;10(1):126-37.
[2] Wang X, Sinn AL, et al. Preclinical activity of a novel multiple tyrosine kinase and aurora kinase inhibitor, ENMD-2076, against multiple myeloma. Br J Haematol. 2010 Aug;150(3):313-25.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.6633 mL
- 13.3166 mL
- 26.6333 mL
- 5 mM
- 0.5327 mL
- 2.6633 mL
- 5.3267 mL
- 10 mM
- 0.2663 mL
- 1.3317 mL
- 2.6633 mL

技术信息

CAS号	934353-76-1	储存条件	粉末 Keep in dark place,Inert atmosphere,Store in freezer, under -20°C 液体 -20°C:3-6 月 -80°C:12月
分子式	C21H25N7	运输	蓝冰
分子量	375.47	别名	Enmd-2076

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NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT00806065	Multiple Myeloma	Phase 1	Completed	-	United States, Indiana ... more >> Indiana University Melvin and Bren Simon Cancer Center Indianapolis, Indiana, United States, 46202 Collapse <<
NCT00658671	Advanced Cancer	Phase 1	Completed	-	United States, Colorado ... more >> University of Colorado Hospital Aurora, Colorado, United States, 80045 United States, Massachusetts Dana Farber/Harvard Cancer Center Boston, Massachusetts, United States Collapse <<
NCT01104675	Ovarian Cancer ... more >> Fallopian Cancer Peritoneal Cancer Collapse <<	Phase 2	Completed	-	United States, Colorado ... more >> University of Colorado Cancer Center Aurora, Colorado, United States, 80045 United States, Illinois University of Chicago Medical Center Chicago, Illinois, United States, 60637 United States, Indiana Indiana University Simon Cancer Center Indianapolis, Indiana, United States, 46202 United States, Massachusetts Dana Farber/Partners Cancer Care Boston, Massachusetts, United States, 02115 United States, New York Memorial Sloan-Kettering Cancer Center New York, New York, United States Canada, Ontario Princess Margaret Hospital Toronto, Ontario, Canada Collapse <<
NCT00904787	Relapsed or Refractory Hematol... more >>ogical Malignancies Collapse <<	Phase 1	Completed	-	Canada, Ontario ... more >> Princess Margaret Hospital Toronto, Ontario, Canada, M5G 2M9 Collapse <<
NCT01719744	-	-	Completed	-	-
NCT01719744	Advanced Meta... more >>static Soft Tissue Sarcoma Collapse <<	Phase 2	Completed	-	Canada, Ontario ... more >> Princess Margaret Cancer Centre Toronto, Ontario, Canada, M5G 2M9 Collapse <<
NCT01914510	Ovarian Clear Cell Carcinoma	Phase 2	Completed	-	Canada, Alberta ... more >> Tom Baker Cancer Centre Calgary, Alberta, Canada, T2N 4N2 Cross Cancer Institute Edmonton, Alberta, Canada, T6G 1Z2 British Columbia Cancer Agency Vancouver, Alberta, Canada, V5Z 4E6 Canada, Ontario London Regional Cancer Program London, Ontario, Canada, N6A 4L6 Ottawa Regional Cancer Centre Ottawa, Ontario, Canada, K1H 8L6 Princess Margaret Cancer Centre Toronto, Ontario, Canada, M5G 2M9 Collapse <<
NCT02234986	Advanced Adult Hepatocellular ... more >>Carcinoma Advanced Fibrolamellar Carcinoma Collapse <<	Phase 2	Completed	-	United States, California ... more >> CASI Site 03 San Francisco, California, United States, 94158 United States, Colorado CASI Site 04 Aurora, Colorado, United States, 80045 United States, Massachusetts CASI Site 02 Boston, Massachusetts, United States, 01003 United States, New York Casi Site 01 New York, New York, United States, 10065 United States, Texas CASI Site 05 Dallas, Texas, United States, 75231 Collapse <<
NCT01639248	Triple Negative Breast Cancer	Phase 2	Completed	-	United States, Colorado ... more >> University of Colorado Cancer Center Aurora, Colorado, United States, 80045 United States, Indiana Inidiana University Melvin and Bren Simon Cancer Center Indianapolis, Indiana, United States, 46202 China Cancer Hospital of Chinese Academy of Medical Science Beijing, China, 100021 Collapse <<

ENMD-2076 Catalog No. CSN18598

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