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CAS No.: 1334237-71-6

Etelcalcetide HCl Catalog No. CSN20404

Synonyms: AMG 416 hydrochloride;KAI-4169 hydrochloride;AMG 416 HCl

Etelcalcetide HCl is the HCl salt of etelcalcetide is a calcium-sensing receptor agonist for the treatment of secondary hyperparathyroidism for patients with chronic kidney disease (CKD) on hemodialysis.

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生物活性

描述Etelcalcetide hydrochloride is the hydrochloride salt of etelcalcetide is a calcium-sensing receptor agonist for the treatment of secondary hyperparathyroidism for patients with chronic kidney disease (CKD) on hemodialysis. Etelcalcetide is administered intravenously at the end of each dialysis session. It functions by binding to and activating the calcium-sensing receptor (CaSR) in the parathyroid gland as an allosteric activator, resulting in PTH reduction and suppression.
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT01896232	Secondary Hyperparathyroidism ... more >> Chronic Kidney Disease Collapse <<	Phase 3	Completed	-	-
NCT01932970	-	-	Completed	-	-
NCT01932970	Hyperparathyroidism, Secondary	Phase 3	Completed	-	-

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参考文献

[1] Block GA, Bushinsky DA, et al. Effect of Etelcalcetide vs Cinacalcet on Serum Parathyroid Hormone in Patients Receiving Hemodialysis With Secondary Hyperparathyroidism: A Randomized Clinical Trial. JAMA. 2017 Jan 10;317(2):156-164.
[2] Subramanian R, Zhu X, et al. Nonclinical Pharmacokinetics, Disposition, and Drug-Drug Interaction Potential of a Novel d-Amino Acid Peptide Agonist of the Calcium-Sensing Receptor AMG 416 (Etelcalcetide). Drug Metab Dispos. 2016 Aug;44(8):1319-31.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 0.9219 mL
- 4.6095 mL
- 9.2190 mL
- 5 mM
- 0.1844 mL
- 0.9219 mL
- 1.8438 mL
- 10 mM
- 0.0922 mL
- 0.4610 mL
- 0.9219 mL

技术信息

CAS号	1334237-71-6	储存条件	粉末 Keep in dark place,Inert atmosphere,Store in freezer, under -20°C 液体 -20°C:3-6 月 -80°C:12月
分子式	C38H74ClN21O10S2	运输	蓝冰
分子量	1084.71	别名	AMG 416 hydrochloride;KAI-4169 hydrochloride;AMG 416 HCl;KAI 4169 HCl;ONO5163 HCl;Etelcalcetide (hydrochloride);AMG-416;KAI-4169;ONO-5163;Etelcalcetide;Telcalcetide. Ac-D-Cys-D-Ala-D-Arg-D-Arg-D-Arg-D-Ala-D-Arg-NH2.Etelcalcetide HCl

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