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CAS No.: 1099-45-2

乙基(三苯基膦)乙酸酯 Catalog No. CSN25357

Synonyms: (Carbethoxymethylene)triphenylphosphorane;Triphenylcarbethoxymethylenephosphorane;Ethyl 2-(triphenylphosphoranylidene)acetate

Ethyl (triphenylphosphoranylidene) acetate is an organophosphorus compound. It is used to replace oxygen centres in ketones and aldehydes with CHCO2Et.

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技术信息

生物活性

描述Ethyl (triphenylphosphoranylidene) acetate is an effective phytopharmaceutical agent. ethyl acetate fraction of E. alba inhibited adipocyte differentiation in 3T3-L1 pre-adipocytes and hMSC derived adipocytes. It inhibited mitotic clonal expansion and caused cell cycle arrest in G1 and S phase. Ethyl acetate fraction of E. alba possesses potent anti-adipogenic as well as anti-dyslipidemic activity and could be projected as an herbal formulation towards obesity^[1]. Ethyl acetate is an industrially relevant ester that is currently produced exclusively through unsustainable processes. A new enzyme (Eat1) from the yeast Wickerhamomyces anomalus that resulted in high ethyl acetate production when expressed in Saccharomyces cerevisiae and Escherichia coli. Purified Eat1 showed alcohol acetyltransferase activity with ethanol and acetyl-CoA^[2]. More ethyl acetate was produced in mixed fermentations using Y3401/Y3604 yeasts than in single fermentations. The highest ethyl acetate yield was 6.41 g/L using a Y3401/Y3604 ratio of 3:1^[3]. The modification of ethyl acetate metabolic pathway is extremely important for the production of ethyl acetate from Saccharomyces cerevisiae^[4].
参考文献

[1] Gupta A, Kumar A, Kumar D, et al. Ethyl acetate fraction of Eclipta alba: a potential phytopharmaceutical targeting adipocyte differentiation. Biomed Pharmacother. 2017;96:572‐583
[2] Kruis AJ, Levisson M, Mars AE, et al. Ethyl acetate production by the elusive alcohol acetyltransferase from yeast. Metab Eng. 2017;41:92‐101
[3] Nagasawa K, Kishida A, Kajiwara M, Kanamatsu T, Takatori K. A simple convenient synthesis of L-[4-13C]glutamine. J Labelled Comp Radiopharm. 2015;58(2):42‐45
[4] Dong J, Wang P, Fu X, Dong S, Li X, Xiao D. Increase ethyl acetate production in Saccharomyces cerevisiae by genetic engineering of ethyl acetate metabolic pathway. J Ind Microbiol Biotechnol. 2019;46(6):801‐808

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.8705 mL
- 14.3524 mL
- 28.7047 mL
- 5 mM
- 0.5741 mL
- 2.8705 mL
- 5.7409 mL
- 10 mM
- 0.2870 mL
- 1.4352 mL
- 2.8705 mL

技术信息

CAS号

1099-45-2

储存条件

粉末: Inert atmosphere,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C22H21O2P

运输

蓝冰

分子量

348.37

别名

(Carbethoxymethylene)triphenylphosphorane;Triphenylcarbethoxymethylenephosphorane;Ethyl 2-(triphenylphosphoranylidene)acetate

溶解度

DMSO	69.0 mg/mL (198.1 mM)

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