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CAS No.: 120-47-8

尼泊金乙酯 Catalog No. CSN15859

Synonyms: 羟苯乙酯;Ethyl parahydroxybenzoate;Ethyl 4-hydroxybenzoate

Ethylparaben, a natural product isolated and purified from the male melon fly Dacus cucurbitae, is the ethyl ester of p-hydroxybenzoic acid, used as an antifungal preservative.

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技术信息

生物活性

描述Ethylparaben (EP), a kind of parabens, has been widely used as a cosmetic and food preservative^[1] . Although EP, as a preservative, had been thought to be safe for humans, some studies showed that it has estrogenic effects and may cause some estrogenicity-related diseases^[1-2]. In vitro studies, EP could significantly stimulate the proliferation of MCF-7 cells at a higher concentration than 17beta-estradiol^[3] . In vivo studies, it was found that 0.02% EP could enhance the fertility of fruit flies, while at a higher concentration, more than 0.10%, EP could suppress the fruit flies' survivability^[1] . Besides these, EP also could increase the incidence of breast cancer in rats^[2] .
参考文献

[1] Liu T, Li Y, et al. Ethylparaben affects lifespan, fecundity, and the expression levels of ERR, EcR and YPR in Drosophila melanogaster. J Insect Physiol. 2014.
[2] Sun L, Yu T, et al. The estrogenicity of methylparaben and ethylparaben at doses close to the acceptable daily intake in immature Sprague-Dawley rats. Sci Rep. 2016.
[3] Okubo T, Yokoyama Y, et al. ER-dependent estrogenic activity of parabens assessed by proliferation of human breast cancer MCF-7 cells and expression of ERalpha and PR. Food Chem Toxicol. 2001;39(12):1225-32.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 6.0179 mL
- 30.0897 mL
- 60.1793 mL
- 5 mM
- 1.2036 mL
- 6.0179 mL
- 12.0359 mL
- 10 mM
- 0.6018 mL
- 3.0090 mL
- 6.0179 mL

技术信息

CAS号

120-47-8

储存条件

粉末: Sealed in dry,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C9H10O3

运输

蓝冰

分子量

166.17

别名

羟苯乙酯;Ethyl parahydroxybenzoate;Ethyl 4-hydroxybenzoate;尼泊金乙

溶解度

DMSO	25.0 mg/mL (150.4 mM)
Water	insoluble
Ethanol	25.0 mg/mL (150.4 mM)

动物实验配方

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