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CAS No.: 202409-33-4
Synonyms: MK-0663;L-791456;MK-663
Etoricoxib is a selective COX2 inhibitor with IC50 of 1.1 ± 0.1 μM and 116 ± 8 μM for COX1.
生物活性
靶点 | COX2 IC50:1.1±0.1μM | COX1 IC50:116±8μM |
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
---|---|---|---|---|---|
NCT01638962 | Osteoarthritis, Knee | Not Applicable | Completed | - | Denmark ... more >> University of Southern Denmark Odense, Region Syddanmark, Denmark, 5230 Collapse << |
NCT00092729 | Dysmenorrhea | Phase 3 | Completed | - | - |
NCT03117894 | Breast Neoplasm Female ... more >> Regional Anesthesia Anesthesia Regional Anesthesia Morbidity Anesthesia Morbidity Collapse << | Not Applicable | Unknown | December 2018 | Sweden ... more >> Östersund Hospital Recruiting Östersund, Jämtland, Sweden, 83183 Contact: Hans Ahlberg, MD +4663153000 hans.ahlberg@regionjh.se Contact: Joakim Johansson, PhD +46703976410 joakim.johansson@regionjh.se Collapse << |
实验方案
技术信息
CAS号 | 202409-33-4 | 储存条件 |
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分子式 | C18H15ClN2O2S | 运输 | 蓝冰 | |||||||||||||
分子量 | 358.84 | 别名 | MK-0663;L-791456;MK-663;L-791,456;Arcoxia;依托考昔 | |||||||||||||
溶解度 |
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动物实验配方 |
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NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
---|
NCT01638962 | Osteoarthritis, Knee | Not Applicable | Completed | - | Denmark ... more >> University of Southern Denmark Odense, Region Syddanmark, Denmark, 5230 Collapse << |
NCT00092729 | Dysmenorrhea | Phase 3 | Completed | - | - |
NCT03117894 | Breast Neoplasm Female ... more >> Regional Anesthesia Anesthesia Regional Anesthesia Morbidity Anesthesia Morbidity Collapse << | Not Applicable | Unknown | December 2018 | Sweden ... more >> Östersund Hospital Recruiting Östersund, Jämtland, Sweden, 83183 Contact: Hans Ahlberg, MD +4663153000 hans.ahlberg@regionjh.se Contact: Joakim Johansson, PhD +46703976410 joakim.johansson@regionjh.se Collapse << |
NCT00716833 | Pain Abdomina... more >>l Surgery Thoracic Surgery Collapse << | Phase 3 | Terminated(poor recruitment) | - | Germany ... more >> Zentrum für Pneumologie und Thoraxchirurgie, Asklepios Fachkliniken München-Gauting Gauting, Germany, 82131 Chirurgische Klinik und Poliklinik, Innenstadt, Klinikum der Universität München München, Germany, 80336 Collapse << |
NCT03011905 | Brachial Plexus Block ... more >> Pain, Postoperative Collapse << | Phase 3 | Active, not recruiting | April 5, 2019 | Norway ... more >> Oslo Universitetssykehus, Ullevaal, dept of anaesthesiology, legevakten Oslo, Norway, 0540 Collapse << |
NCT02456363 | Ankylosing Spondylitis | Phase 2 | Recruiting | December 2019 | Taiwan ... more >> Chung Shan Medical University Hospital Recruiting Taichung, Taiwan Contact: Cheng-Chung Wei, M.D., Ph.D. 24739595 ext 34718 wei3228@gmail.com Collapse << |
NCT01294696 | - | - | Completed | - | - |
NCT01361789 | Rupture of Anterior Cruciate L... more >>igament Collapse << | Phase 4 | Completed | - | Norway ... more >> Baerum Hospital Rud, Norway, 1309 Collapse << |
NCT02954484 | Pain, Postoperative | Phase 3 | Completed | - | - |
NCT01294696 | - | - | Completed | - | - |
NCT02438709 | Primary Hypertrophic Osteoarth... more >>ropathy Collapse << | Phase 3 | Unknown | July 2016 | China, Beijing ... more >> Peking Union Medical College Hospital Recruiting Beijing, Beijing, China, 100005 Contact: Weibo Xia, MD 86-10-6915-5076 xiaweibo@medmail.com.cn Collapse << |
NCT01398930 | Knee Osteoarthritis | Not Applicable | Completed | - | Greece ... more >> National and Kapodistrian University Medical School Athens, Greece, 11527 Collapse << |
NCT01300780 | Color Changes During Tooth For... more >>mation Collapse << | Not Applicable | Completed | - | Brazil ... more >> Universidade Estadual de Ponta Grossa Guarapuava, Paraná, Brazil, 84030900 Collapse << |
NCT00733421 | Postoperative Pain | Phase 4 | Completed | - | Sweden ... more >> Foot & Ancle Surgical Center Stockholm, Sweden, 11542 Collapse << |
NCT00733421 | - | - | Completed | - | - |
NCT00264147 | Rheumatoid Arthritis | Phase 2 | Completed | - | - |
NCT00092742 | Rheumatoid Arthritis | Phase 3 | Completed | - | - |
NCT00092703 | Osteoarthritis | Phase 3 | Completed | - | - |
NCT01017380 | Anterior Cruciate Ligament Inj... more >>ury Collapse << | Phase 3 | Completed | - | Thailand ... more >> Prince of Songkla University Hat Yai, Songkhla, Thailand, 90110 Collapse << |
NCT00095017 | Bone Neoplasms | Phase 2 | Withdrawn | - | - |
NCT00092755 | Osteoarthritis | Phase 3 | Completed | - | - |
NCT00264147 | - | - | Completed | - | - |
NCT00427999 | Prostate Cancer | Phase 2 | Completed | - | Germany ... more >> Novartis Investigative Site Bad Reichenhall, Germany, 83435 Novartis Investigative Site Bonn, Germany, 53105 Novartis Investigative Site Hamburg, Germany, 20246 Novartis Investigative Site Hamburg, Germany, 22607 Novartis Investigative Site Kassel, Germany, 34131 Novartis Investigative Site Markkleeberg, Germany, 04416 Novartis Investigative Site Passau, Germany, 94032 Novartis Investigative Site Planegg, Germany, 82152 Novartis Investigative Site Regensburg, Germany, 93053 Novartis Investigative Site Tübingen, Germany, 72076 Collapse << |
NCT00970112 | Pain Control | Phase 2 Phase 3 | Completed | - | Brazil ... more >> UEPG Ponta Grossa, Paraná, Brazil Collapse << |
NCT00427999 | - | - | Completed | - | - |
NCT00380627 | Pain | Phase 4 | Completed | - | - |
NCT01304069 | Healthy | Phase 1 | Completed | - | Finland ... more >> Department of Anaesthesiology, Intensive Care, Emergency Care and Pain Medicine, Turku University and Turku University Hospital Turku, Finland Collapse << |
NCT00269191 | Osteoarthritis | Phase 3 | Completed | - | - |
NCT00092768 | Osteoarthritis | Phase 3 | Completed | - | - |
NCT00092781 | Osteoarthritis | Phase 3 | Completed | - | - |
NCT00694369 | Postoperative Dental Pain | Phase 3 | Completed | - | - |
NCT00792376 | Achilles Tendinopathy | Phase 4 | Completed | - | Argentina ... more >> Argentine Tennis Association Buenos Aires, Argentina Collapse << |
NCT00694369 | - | - | Completed | - | - |
NCT01269515 | HIV | Phase 2 | Completed | - | Norway ... more >> Department of Infectious Diseases, Oslo University Hospital Oslo, Norway, 0407 The Biotechnology Centre, University of Oslo Oslo, Norway, 0407 Collapse << |
NCT01614301 | Advanced Melanoma | Phase 1 Phase 2 | Unknown | May 2016 | Germany ... more >> University of Regensburg Recruiting Regensburg, Bavaria, Germany, 93053 Contact: Albrecht Reichle, Professor +499419440 albrecht.reichle@UKR.de Sub-Investigator: Martin Vogelhuber, MD Sub-Investigator: Stephanie Mayer, MD Sub-Investigator: Christina Hart, MD Sub-Investigator: Matthias Grube, MD Sub-Investigator: Susanne Gantner, MD Collapse << |
NCT02503839 | Tuberculosis | Phase 1 | Recruiting | December 2019 | Norway ... more >> Haukeland University Hospital Recruiting Bergen, Norway, 5020 Contact: Tehmina Mustafa, PhD, MD +47 97633677 tehmina.mustafa@uib.no Oslo University Hospital Recruiting Oslo, Norway, 0424 Contact: Anne M Dyrhol-Riise, PhD, MD +4792857261 a.m.d.riise@medisin.uio.no Collapse << |
NCT00393354 | Recurrent Low Back Pain | Phase 3 | Completed | - | - |
NCT03542955 | Cervical Osteoarthritis | Not Applicable | Recruiting | May 1, 2019 | Lebanon ... more >> New Mazloum Hospital Recruiting Tripoli, Lebanon Contact: Omar Tabbouche, Pharm D +9613433032 omartabbouche@gmail.com Collapse << |
NCT00393211 | Recurrent Low Back Pain | Phase 3 | Completed | - | - |
NCT00090181 | Chronic Low Back Pain | Phase 4 | Completed | - | - |
NCT00380523 | Pain | Phase 4 | Completed | - | - |
NCT00738608 | - | - | Completed | - | Germany ... more >> Marienkrankenhaus Soest, Germany, 59494 Collapse << |
NCT01980940 | Osteoarthritis Pain | Phase 1 Phase 2 | Completed | - | - |
NCT00542087 | Osteoarthritis | Phase 3 | Completed | - | - |
NCT01190722 | Hallux Valgus ... more >> Postoperative Pain Collapse << | Phase 4 | Withdrawn(The study site was c... more >>losed down) Collapse << | - | - |
NCT02884986 | Adverse Anesthesia Outcome | Not Applicable | Completed | - | Israel ... more >> Bnai Zion Medical Center Haifa, Israel Collapse << |
NCT00525993 | Sprains and Strains ... more >> Contusions Collapse << | Phase 4 | Unknown | September 2009 | Brazil ... more >> NEO Not yet recruiting São Paulo, SP, Brazil, 04084100 Contact: Rogerio Silva 011 81716767 rgtsilva@uol.com.br Principal Investigator: Rogerio T Silva, MD, PhD Sub-Investigator: Fabio C Petri, MD Collapse << |
NCT01002690 | Asthma | Not Applicable | Completed | - | Sweden ... more >> Karolinska University Hospital Stockholm, Sweden, SE-141 86 Collapse << |
NCT01077843 | - | - | Completed | - | - |
NCT00140972 | Osteoarthritis | Phase 4 | Completed | - | - |
NCT03582332 | Axial Spondyloarthritis | Phase 4 | Completed | - | - |
NCT00242489 | Osteoarthritis | Phase 2 | Completed | - | - |
NCT00373464 | Hysterectomy ... more >>Tubal Excision Ovariectomy Postoperative Pain Collapse << | Phase 3 | Completed | - | Norway ... more >> Ullevaal University Hospital Oslo, Norway Collapse << |
NCT00149253 | a Single-Dose of Etoricoxib ... more >> Post-Operative Morphine Consumption Total Pain Relief Over 8 Hr(TOPAR8) Post Transabdominal Hysterectomy Collapse << | Phase 3 | Completed | - | Thailand ... more >> Warporn Chau-in KhonKaen University, KhonKaen, Thailand, 40002 Collapse << |
NCT00142558 | Acute Gout | Phase 4 | Completed | - | - |
NCT01979510 | Low Back Pain | Phase 3 | Withdrawn | May 2014 | - |
NCT01462370 | Dysmenorrhea | Phase 3 | Completed | - | - |
NCT01572675 | - | - | Completed | - | - |
NCT01572675 | - | - | Completed | - | - |
NCT01980940 | - | - | Completed | - | - |
NCT00554346 | Post-operational Pain | Phase 4 | Completed | - | Taiwan ... more >> National Taiwan University Hospital Taipei, Taiwan Collapse << |
NCT00250445 | Rheumatoid Arthritis,Osteoarth... more >>ritis Collapse << | Phase 3 | Completed | - | - |
NCT00954785 | Sprain | Phase 4 | Withdrawn(The study was termin... more >>ated by Merck USA. The company did not supply drugs for the study.) Collapse << | July 2011 | South Africa ... more >> Kuilsriver Netcare Hospital, 33 Van Riebeeck Road, Kuilsriver Cape Town, Western Cape, South Africa, 7580 Sports Medicine Clinic, Sports Science Institute of South Africa Cape Town, Western Cape, South Africa, 7700 Collapse << |
NCT03422575 | Healthy | Not Applicable | Completed | - | Indonesia ... more >> PT Equilab International Jakarta, Indonesia, 12430 Collapse << |
NCT01462370 | - | - | Completed | - | - |
NCT00752921 | Headache | Phase 4 | Unknown | October 2008 | Israel ... more >> Shaare Zedek Medical Center Not yet recruiting Jerusalem, Israel, 91031 Contact: Zev S Wimpfheimer, MD 972 50 868 5466 zevw@hotmail.com Collapse << |
NCT00793052 | Trismus Edema... more >> Pain Collapse << | Not Applicable | Unknown | December 2009 | - |
NCT00763685 | Pain | Phase 4 | Terminated(The gynecological l... more >>aparoscopic surgery transition to day surgery made following the study protocol not possible.) Collapse << | - | Estonia ... more >> East Tallinn Central Hospital Tallinn, Estonia, 10138 Collapse << |
NCT00440739 | Pain | Phase 4 | Completed | - | Thailand ... more >> Faculty of Medicine Siriraj Hospital, Mahidol University Bangkok, Thailand, 10700 Collapse << |
NCT01271348 | Muscle Pain | Phase 1 | Completed | - | Germany ... more >> X-pert Med GmbH Jena, Germany, 07745 Collapse << |
NCT00876317 | Soft Tissue Injuries of the Sh... more >>oulder Tenosynovitis and Bursitis Affecting the Shoulder Collapse << | Phase 3 | Terminated(Change in current a... more >>reas of research interest of the collaborator) Collapse << | - | Peru ... more >> Clínica Virgen Milagrosa Lima, Peru, Lima 34 Collapse << |
NCT00746720 | Pain Osteoart... more >>hritis, Hip Postoperative Pain Collapse << | Phase 2 | Terminated(Patient recruitment... more >> difficulties) Collapse << | - | Germany ... more >> HELIOS Klinikum Berlin Berlin, Germany, D-13125 Collapse << |
NCT00799149 | Knee Arthroscopy | Phase 4 | Completed | - | Israel ... more >> Meir Medical Center Kfar-Saba, Israel, 44281 Collapse << |
NCT00927004 | Osteoarthritis ... more >> Pain Collapse << | Phase 4 | Completed | - | Australia, Western Australia ... more >> Royal Perth Hospital Perth, Western Australia, Australia, 6000 Collapse << |
NCT00565682 | Laparoscopic Surgery for Appen... more >>dicitis Laparoscopic Surgery for Cholecystitis Laparoscopic Surgery for Ovarian Cysts Collapse << | Phase 4 | Completed | - | - |
NCT01246362 | Knee Osteoarthritis | Phase 2 | Completed | - | Singapore ... more >> Singapore General Hospital Singapore, Singapore, 169608 Collapse << |
NCT03697733 | Abnormal Uterine Bleeding | Not Applicable | Not yet recruiting | November 1, 2019 | - |
NCT00529594 | Proliferative Diabetic Retinop... more >>athy Collapse << | Not Applicable | Completed | - | Brazil ... more >> Clinica Oftalmologica do Hospital das Clinicas da Faculdade de Medicina da Universidade de São Paulo São Paulo, SP, Brazil, 05403-000 Collapse << |
NCT00820027 | Pain, Postoperative | Phase 3 | Completed | - | - |
NCT00788710 | Acute Pain Following a Total A... more >>bdominal Hysterectomy Collapse << | Phase 3 | Completed | - | - |
NCT00788710 | - | - | Completed | - | - |
NCT00855777 | Dental Extraction | Phase 4 | Unknown | April 2010 | - |
NCT00935116 | Acute Pain | Phase 4 | Unknown | September 2010 | - |
NCT01208207 | - | - | Completed | - | - |
NCT01229774 | Coxarthrosis ... more >>Arthroplasties Hip Replacement Perioperative Blood Loss Collapse << | Phase 3 | Completed | - | Germany ... more >> Department of Orthopedic Surgery Bad Abbach, Bavaria, Germany, 93077 Collapse << |
NCT00755521 | Fibromyalgia | Phase 4 | Unknown | December 2012 | Israel ... more >> Department of Medicine 'D', Meir Medical Center Recruiting Kfar-Saba, Israel, 44281 Contact: Howard Amital, MD MHA 972-9-7472598 Howard.Amital@sheba.health.gov.il Collapse << |
NCT01619150 | Osteoarthritis | Phase 2 | Completed | - | Denmark ... more >> CCBR A/S Aalborg, Denmark, 9000 Collapse << |
NCT01327638 | - | - | Completed | - | - |
NCT01088256 | Causalgia Pol... more >>yneuropathy Postherpetic Neuralgia Peripheral Nerve Injury Radiculopathy Collapse << | Phase 2 | Terminated | - | Germany ... more >> Bergmannsheil department of pain therapy Bochum, Nordrhein-Westfalen, Germany, 44789 Collapse << |
NCT00945035 | - | - | Completed | - | - |
NCT01344720 | Low Back Pain | Phase 4 | Unknown | June 2011 | Italy ... more >> Unità di riabilitazione neurofisiologica Istituto Scientifico di Riabilitazione di Montescano Not yet recruiting Montescano (PV), Pavia, Italy, 27040 Principal Investigator: Roberto Casale, Professore Dipartimento di Scienze della Salute Anestesia, Rianimazione e Terapia del dolore - Università degli Studi di L'Aquila Ospedale San Salvatore L'Aquila Not yet recruiting L'Aquila, Italy, 67100 Principal Investigator: Franco Marinangeli, Dottore Clinica Anestesia e Rianimazione Azienda Ospedaliera Universitaria Policlinico Tor Vergata Not yet recruiting Roma, Italy, 00133 Principal Investigator: Antonio Gatti, Dottore Dipartimento Emergenza ed Accettazione Ospedale Civile G. Mazzini Teramo Not yet recruiting Teramo, Italy, 64100 Principal Investigator: Pier Luigi Orsini, Dottore Dipartimento di Medicina Interna- Università degli Studi di Perugia Azienda Ospedaliera S.Maria - Clinica Medica Not yet recruiting Terni, Italy, 05100 Principal Investigator: Stefano Coaccioli, Professore Collapse << |
NCT01208207 | Spondylitis, Ankylosing | Phase 3 | Completed | - | - |
NCT00756873 | Tonsillectomy | Phase 3 | Unknown | December 2009 | Germany ... more >> Universtiy Hospital Regensburg Not yet recruiting Regensburg, Germany, 93053 Contact: Michael Bucher, MD, PhD xx49-941-944- ext 0 michael.bucher@klinik.uni.regensburg.de Principal Investigator: Michael Bucher, MD, PhD Sub-Investigator: Thomas Kühnel, MD, PhD Weiden Clinic Not yet recruiting Weiden i.d. OPf., Germany, 92637 Contact: Jürgen Altmeppen, MD xx49-9 61-303- ext 32 02 anaesthesie@klinikum-weiden.de Principal Investigator: Jürgen Altmeppen, MD Collapse << |
NCT00945035 | Pain | Phase 1 | Completed | - | - |
NCT01429168 | Osteoarthritis | Phase 4 | Withdrawn | August 2012 | - |
NCT01148303 | Headache Fast... more >>ing Fasting Headache Ramadan Headache Collapse << | Phase 4 | Completed | - | Israel ... more >> Shaare Zedek Medical Center Jerusalem, Israel Collapse << |
NCT01259830 | Post-operative Pain | Phase 4 | Terminated | - | Germany ... more >> St. Hedwig Kliniken Berlin GmbH, Department of Anesthesiology and Intensive Care Medicine Berlin, Germany, 10115 Department of Anesthesiology, Sana-Klinikum Lichtenberg, Oskar-Ziethen-Krankenhaus Berlin, Germany, 10365 Department of Anesthesiology and Intensive Care Medicine, Campus Virchow Klinikum/Campus Charité Mitte, Charité Universitätsmedizin Berlin, Germany, 13353 Department of Anesthesiology, Johannes Wesling Klinikum Minden Mühlenkreiskliniken (AöR) Minden, Germany, 32429 Collapse << |
NCT00757627 | Pain | Phase 4 | Completed | - | - |
NCT00757627 | - | - | Completed | - | - |
NCT01208181 | - | - | Completed | - | - |
NCT02534610 | Postoperative Pain | Not Applicable | Completed | - | Romania ... more >> Foisor Orthopedics Clinical Hospital Bucharest, Romania, 021382 Collapse << |
NCT01067430 | Rheumatoid Arthritis | Phase 4 | Unknown | April 2011 | United Kingdom ... more >> Northumbria Healthcare NHS Foundation Trust Not yet recruiting North Shields, Tyne and Wear, United Kingdom, NE29 8NH Principal Investigator: David J Walker, MD Collapse << |
NCT01554163 | - | - | Completed | - | - |
NCT01091675 | - | - | Completed | - | - |
NCT02149758 | Cyclooxygenase Two Inhibitors ... more >> Etoricoxib Periodontitis Superoxide Dismutase Saliva Collapse << | Phase 4 | Completed | - | India ... more >> Tatyasaheb kore Dental College And Research Centre Kolhapur, Maharashtra, India, 416137 Collapse << |
NCT01264237 | Postherpetic Neuralgia ... more >> Neuralgia Collapse << | Phase 4 | Unknown | April 2012 | United Kingdom ... more >> MAC (UK) Neruoscience Ltd Recruiting Liverpool, United Kingdom, L18 1HQ Principal Investigator: Stuart Ratcliffe, MBChB, MFPM, FRSM MAC (UK) Neuroscience Ltd Recruiting Manchester, United Kingdom, M32 0UT Principal Investigator: Stuart Ratcliffe, MBChB, MFPM, FRSM Collapse << |
NCT01554163 | Osteoarthritis of the Knee | Phase 3 | Completed | - | - |
NCT02750917 | Postoperative Pain | Phase 3 | Completed | - | - |
NCT01685424 | - | - | Completed | - | - |
NCT01091675 | Ankylosing Spondylitis | Phase 3 | Completed | - | Spain ... more >> Central Hospital of Asturias Oviedo, Asturias, Spain, 33006 Parc Tauli Hospital Sabadell, Barcelona, Spain Sant Rafael Hospital Barcelona, Spain, 08035 Clinic I Provincial Hospital Barcelona, Spain, 08036 Bellvitge Hospital Barcelona, Spain, 08907 Reina Sofia University Hospital Cordoba, Spain, 14004 Ramon Y Cajal Hospital Madrid, Spain, 28034 University Hospital 12 Octubre Madrid, Spain, 28041 Puerta de Hierro Hospital Madrid, Spain, 28222 Hospital General of Mostoles Madrid, Spain, 28935 University Hospital de la Princesa Madrid, Spain Virgen de la Arrixaca Hospital Murcia, Spain, 30120 Hospital Clinic of Salamanca Salamanca, Spain, 37007 Sant Pau i Santa Tecla Hospital Tarragona, Spain Collapse << |
NCT01022190 | - | - | Completed | - | - |
NCT01208181 | Arthritis, Rheumatoid | Phase 3 | Completed | - | - |
NCT02568735 | Pain, Postoperative | Phase 4 | Completed | - | - |
NCT01022190 | Ossification, Heterotopic | Phase 4 | Completed | - | Netherlands ... more >> Radboud University Nijmegen Medical Center Nijmegen, Netherlands, 6500 HB Collapse << |
靶点 | Description | IC50 |
---|---|---|
COX2 | IC50:1.1±0.1μM | |
COX1 | IC50:116±8μM |
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