生物活性

• 描述BIBX 1382 is a potent, selective inhibitor of EGFR tyrosine kinase (IC50 = 3 nM) and displays > 1000-fold lower potency against ErbB2 (IC50 = 3.4 μM) and a range of other related tyrosine kinases (IC50 > 10 μM).
• 临床研究

• NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
  NCT00003980	Unspecified Adult Solid Tumor,... more >> Protocol Specific Collapse <<	Phase 1	Suspended	-	Austria ... more >> Innsbruck Universitaetsklinik Innsbruck, Austria, A-6020 Kaiser Franz Josef Hospital Vienna, Austria, A-1100 Belgium Institut Jules Bordet Brussels, Belgium, 1000 Ludwig Institute for Cancer Research-Brussels Branch Brussels, Belgium, B-1200 Universitair Ziekenhuis Antwerpen Edegem, Belgium, B-2650 U.Z. Gasthuisberg Leuven, Belgium, B-3000 Denmark Herlev Hospital - University Hospital of Copenhagen Herlev, Denmark, DK-2730 France Centre Jean Perrin Clermont-Ferrand, France, 63011 Centre Leon Berard Lyon, France, 69373 CRLCC Nantes - Atlantique Nantes-Saint Herblain, France, 44805 Institut Claudius Regaud Toulouse, France, 31052 Institut Gustave Roussy Villejuif, France, F-94805 Germany Universitaetsklinik und Strahlenklinik - Essen Essen, Germany, D-45122 Klinikum Nurnberg Nuremberg (Nurnberg), Germany, D-90419 Netherlands Antoni van Leeuwenhoekhuis Amsterdam, Netherlands, 1066 CX Academisch Ziekenhuis der Vrije Universiteit Amsterdam, Netherlands, 1117 MB Academisch Ziekenhuis Groningen Groningen, Netherlands, 9713 EZ University Medical Center Nijmegen Nijmegen, Netherlands, NL-6252 HB Rotterdam Cancer Institute Rotterdam, Netherlands, 3075 EA Norway Norwegian Radium Hospital Oslo, Norway, N-0310 Switzerland University Hospital Basel, Switzerland, CH-4031 Inselspital, Bern Bern, Switzerland, CH-3010 Kantonsspital - Saint Gallen Saint Gallen, Switzerland, CH-9007 United Kingdom Newcastle General Hospital Newcastle Upon Tyne, England, United Kingdom, NE4 6BE Ninewells Hospital and Medical School Dundee, Scotland, United Kingdom, DD1 9SY Western General Hospital Edinburgh, Scotland, United Kingdom, EH4 9NQ C.R.C. Beatson Laboratories Glasgow, Scotland, United Kingdom, G61 1BD Collapse <<

• 参考文献

• [1] Solca FF, Baum A, et al. Inhibition of epidermal growth factor receptor activity by two pyrimidopyrimidine derivatives. J Pharmacol Exp Ther. 2004 Nov;311(2):502-9. Epub 2004 Jun 15.

  [2] Solca FF, Baum A, et al. Inhibition of epidermal growth factor receptor activity by two pyrimidopyrimidine derivatives. J Pharmacol Exp Ther. 2004 Nov;311(2):502-9.