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CAS No.: 73151-29-8

Fenticonazole Nitrate/硝酸芬替康唑 Catalog No. CSN11006

Synonyms: REC 15-1476;Fenticonazole (nitrate);Falvin

Fenticonazole Nitrate is an imidazole antifungal drug and a conazole antifungal drug used for the treatment of vaginal candidiasis.

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技术信息

生物活性

描述Fenticonazole nitrate is a broad spectrum antimycotic, also active as antibacterial. Fenticonazole nitrate (1 g) was administered as vaginal ovules, once daily on days 1 and 3. Eradication (direct phase-contrast microscopy of vaginal swabs and/or microbiological culture) on day 8 was 90% (C. albicans, 26/29, p < 0.001), 70% (T. vaginalis, 7/10, p = 0.161), 67% (G. vaginalis, 22/33, p < 0.009), and 45% (mixed infection, 13/29, p = 0.001). After 28 days, relapse was 0% for candidiasis and trichomoniasis, 27% (6/22) for G. vaginalis, and 23% (3/13) for mixed infection^[3]. Fenticonazole showed in vitro at pH range 4-5 the highest activity against yeasts^[4]. Based on the excretion data, the extent of vaginal absorption of fenticonazole nitrate in women with vulvovaginal candidiasis was 1.81 +/- 0.57% of the dose, while in women with normal cervicovaginal mucosa it accounted for 0.58 +/- 0.28% of the administered dose. The vaginal administration of one ovule containing 1000 mg of fenticonazole nitrate seems to be devoid of risk for patients^[5].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.9290 mL
- 9.6448 mL
- 19.2897 mL
- 5 mM
- 0.3858 mL
- 1.9290 mL
- 3.8579 mL
- 10 mM
- 0.1929 mL
- 0.9645 mL
- 1.9290 mL

技术信息

CAS号

73151-29-8

储存条件

粉末: Inert atmosphere,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C24H21Cl2N3O4S

运输

蓝冰

分子量

518.41

别名

REC 15-1476;Fenticonazole (nitrate);Falvin;Lomexin;REC 15/1476;TX-15338;硝酸芬替康唑

溶解度

DMSO	103.0 mg/mL (198.7 mM)
Water	Insoluble
Ethanol	2.0 mg/mL (3.9 mM)

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Fenticonazole Nitrate/硝酸芬替康唑 Catalog No. CSN11006

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