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CAS No.: 167933-07-5

Flibanserin/氟立班丝氨 Catalog No. CSN11019

Synonyms: BIMT-17;BIMT-17BS;EBD-6396

Flibanserin is a serotonergic antidepressant used to treat hypoactive sexual desire disorder. It is also a P-Glycoprotein Inhibitor.

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生物活性

实验方案

技术信息

生物活性

描述Flibanserin, also named as BIMT 17, is a kind of 5-HT2A receptor antagonist and 5-HT1A receptor full agonist. In vitro studies, it was found that flibanserin showed a good affinity for 5-HT1A and 5-HT2A receptors with the pKi of 7.72 and 6.90 respectively in cerebral cortical, while no appreciable affinity for the other 5-HT receptor subtypes. Besides this, flibanserin could also reduce the forskolin-stimulated cAMP accumulation in the cerebral cortex and in the hippocampus, as well as inhibit the 5-HT-induced phosphatidylinositol turnover in the cerebral cortex^[3]. In vivo studies, flibanserin could act as a full agonist in the dorsal raphe nucleus (DRN) and the medial prefrontal cortex (mPFC), but as a partial agonist in the CA3 region of the hippocampus in the rat brain, when applied by the local microiontophoretic^[4]. In addition, systemic administration of flibanserin could contribute to the change of some monoamine's level in rat brain, such as neurotransmitters serotonin (5-HT), norepinephrine (NE) and so on^[5].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT00360555	Sexual Dysfunctions, Psycholog... more >>ical Collapse <<	Phase 3	Completed	-	-
NCT00491829	Sexual Dysfunctions, Psycholog... more >>ical Collapse <<	Phase 3	Completed	-	-
NCT00360555	-	-	Completed	-	-

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参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.5615 mL
- 12.8073 mL
- 25.6146 mL
- 5 mM
- 0.5123 mL
- 2.5615 mL
- 5.1229 mL
- 10 mM
- 0.2561 mL
- 1.2807 mL
- 2.5615 mL

技术信息

CAS号

167933-07-5

储存条件

粉末: Sealed in dry,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C20H21F3N4O

运输

蓝冰

分子量

390.40

别名

BIMT-17;BIMT-17BS;EBD-6396;氟立班丝氨

溶解度

DMSO	300.0 mg/mL (768.4 mM) warming
Water	insoluble

动物实验配方

IP	2% DMSO+2% Tween80+30% PEG300+water	6 mg/mL	clear
PO	0.5% CMC-Na	32 mg/mL	suspension

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NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT00360555	Sexual Dysfunctions, Psycholog... more >>ical Collapse <<	Phase 3	Completed	-	-
NCT00491829	Sexual Dysfunctions, Psycholog... more >>ical Collapse <<	Phase 3	Completed	-	-
NCT00360555	-	-	Completed	-	-
NCT00491829	-	-	Completed	-	-
NCT01040208	Sexual Dysfunctions, Psycholog... more >>ical Depression Collapse <<	Phase 3	Terminated(Study terminated by... more >> Sponsor for administrative reasons prior to completion) Collapse <<	-	-
NCT00360243	-	-	Completed	-	-
NCT00360243	Sexual Dysfunctions, Psycholog... more >>ical Collapse <<	Phase 3	Completed	-	-
NCT01103362	Sexual Dysfunctions, Psycholog... more >>ical Collapse <<	Phase 3	Terminated(administrative reas... more >>ons) Collapse <<	-	-
NCT01103362	-	-	Terminated(administrative reas... more >>ons) Collapse <<	-	-
NCT01134965	Healthy	Phase 1	Completed	-	Germany ... more >> 511.158.1 Boehringer Ingelheim Investigational Site Biberach, Germany Collapse <<
NCT00441558	-	-	Terminated(terminated for admi... more >>nistrative reasons) Collapse <<	-	-
NCT00996164	Sexual Dysfunctions, Psycholog... more >>ical Collapse <<	Phase 3	Completed	-	-
NCT00441558	Sexual Dysfunctions, Psycholog... more >>ical Collapse <<	Phase 3	Terminated(terminated for admi... more >>nistrative reasons) Collapse <<	-	-
NCT00277914	Sexual Dysfunctions, Psycholog... more >>ical Collapse <<	Phase 3	Completed	-	-
NCT01057901	Sexual Dysfunctions, Psycholog... more >>ical Collapse <<	Phase 3	Terminated(Study terminated fo... more >>r administrative reasons.) Collapse <<	-	-
NCT00996372	Sexual Dysfunctions, Psycholog... more >>ical Collapse <<	Phase 3	Completed	-	-
NCT01040208	-	-	Terminated(Study terminated by... more >> Sponsor for administrative reasons prior to completion) Collapse <<	-	-
NCT01057901	-	-	Terminated(Study terminated fo... more >>r administrative reasons.) Collapse <<	-	-
NCT00996164	-	-	Completed	-	-
NCT00601367	-	-	Completed	-	-
NCT00601367	Sexual Dysfunctions, Psycholog... more >>ical Collapse <<	Phase 3	Completed	-	-
NCT01188603	Sexual Dysfunctions, Psycholog... more >>ical Collapse <<	Phase 1	Completed	-	United States, Florida ... more >> 511.146.01003 Boehringer Ingelheim Investigational Site Orlando, Florida, United States United States, Kansas 511.146.01005 Boehringer Ingelheim Investigational Site Wichita, Kansas, United States United States, Michigan 511.146.01001 Boehringer Ingelheim Investigational Site Kalamazoo, Michigan, United States United States, Tennessee 511.146.01004 Boehringer Ingelheim Investigational Site Knoxville, Tennessee, United States Collapse <<
NCT00360529	Sexual Dysfunctions, Psycholog... more >>ical Collapse <<	Phase 3	Completed	-	-
NCT00360529	-	-	Completed	-	-
NCT03707340	-	-	Recruiting	September 2019	United States, New Jersey ... more >> Memoral Sloan Kettering Basking Ridge Recruiting Basking Ridge, New Jersey, United States, 07920 Contact: Shari Goldfarb, MD 646-888-5080 Memoral Sloan Kettering Monmouth Recruiting Middletown, New Jersey, United States, 07748 Contact: Shari Goldfarb, MD 646-888-5080 United States, New York Memorial Sloan Kettering Cancer Center @ Commack Recruiting Commack, New York, United States, 11725 Contact: Shari Goldfarb, MD 646-888-5080 Memoral Sloan Kettering Westchester Recruiting Harrison, New York, United States, 10604 Contact: Shari Goldfarb, MD 646-888-5080 Memorial Sloan - Kettering Cancer Center Recruiting New York, New York, United States, 10021 Contact: Shari Goldfarb, MD 646-888-5080 Memorial Sloan Kettering @ Rockville Recruiting Rockville Centre, New York, United States, 11570 Contact: Shari Goldfarb, MD 646-888-5080 Collapse <<
NCT02770768	Hypoactive Sexual Desire Disor... more >>der Collapse <<	Not Applicable	Recruiting	June 1, 2019	United States, Illinois ... more >> University of Chicago Recruiting Chicago, Illinois, United States, 60637 Contact: Erika Kaske 773-834-5264 ekaske@yoda.bsd.uchicago.edu Contact: Stephanie Cacioppo, PhD 773-702-6983 scacioppo@yoda.bsd.uchicago.edu Principal Investigator: Stephanie Cacioppo, PhD Sub-Investigator: Jon E Grant, JD, MD, MPH Sub-Investigator: Royce Lee, MD Collapse <<
NCT00996372	-	-	Completed	-	-
NCT02714049	Hypoactive Sexual Desire Disor... more >>der Collapse <<	Phase 4	Active, not recruiting	March 2019	United States, California ... more >> San Diego Sexual Medicine San Diego, California, United States, 92120 Collapse <<
NCT01188603	-	-	Completed	-	-

Flibanserin/氟立班丝氨 Catalog No. CSN11019

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