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CAS No.: 30484-77-6

Flunarizine 2HCl/盐酸氟桂利嗪 Catalog No. CSN11028

Synonyms: KW-3149;R14950;Sibelium HCl

Flunarizine 2HCl is a dual Na+/Ca2+ channel (T-type) blocker with neuroprotective property.

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400-920-2911

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靶点选择性

生物活性

实验方案

技术信息

生物活性

靶点 Calcium Channel

Ki:68nM
描述Flunarizine dihydrochloride (FHC), a calcium antagonist, is used for the prophylaxis to migraine. The solubility of the poorly soluble FHC was successfully improved by preparing it as a nano emulsion^[3]. The most common indication for flunarizine use was chronic migraine, followed by migraine with aura, sporadic hemiplegic migraine, familial hemiplegic migraine and new daily persistent headache with migrainous features. The most common dose used was 10 mg per day. The most common adverse events were tiredness, mood change and weight gain^[4]. Moreover, benefit of flunarizine prophylaxis on headache severity, frequency, and duration in children with Sturge-Weber syndrome without severe side effects^[5]. In an 8-week study, 10 mg/d flunarizine is more effective than 50 mg/d topiramate for CM (Chronic migraine) prophylaxis in patients^[6]. Adding tSNS (transcutaneous supraorbital neurostimulation) to flunarizine can improve the therapeutic efficacy of migraine prophylaxis without increasing the adverse effects^[7].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT03461874	Migraine Without Aura	Not Applicable	Recruiting	July 15, 2021	Italy ... more >> Fondazione IRCCS Istituto Neurologico C. Besta, Neuroalgology Unit Recruiting Milano, Italy, 20133 Contact: Licia Grazzi, MD licia.grazzi@istituto-besta.it Principal Investigator: Licia Grazzi, MD Collapse <<
NCT02580968	Migraine	Not Applicable	Completed	-	China ... more >> Longhua Hospital,Shanghai University of Traditional Chinese Medicine Shanghai, China, 200032 Collapse <<
NCT02747940	Chronic Pain ... more >>Chronic Migraine Fibromyalgia Collapse <<	Phase 4	Recruiting	-	Taiwan ... more >> Headache Center, Teipei Veterans General Hospital Recruiting Taipei, Taiwan, 112 Contact: Shuu-Jiun Wang, MD +886-2-28712121 ext 2425 sjwang@vghtpe.gov.tw Contact: Jong-Ling Fuh, MD +886-2-28712121 ext 3256 jlfuh@vghtpe.gov.tw Principal Investigator: Shuu-Jiun Wang, MD Collapse <<

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参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.0946 mL
- 10.4730 mL
- 20.9461 mL
- 5 mM
- 0.4189 mL
- 2.0946 mL
- 4.1892 mL
- 10 mM
- 0.2095 mL
- 1.0473 mL
- 2.0946 mL

技术信息

CAS号

30484-77-6

储存条件

粉末: Inert atmosphere,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C26H28Cl2F2N2

运输

蓝冰

分子量

477.42

别名

KW-3149;R14950;Sibelium HCl;Flunarizine (hydrochloride);Flunarizine hydrochloride;Flunarizine HCl;EINECS 250-216-6;盐酸氟桂利嗪

溶解度

DMSO	5.0 mg/mL (10.5 mM)
Water	Insoluble
Ethanol	3.0 mg/mL (6.3 mM)

动物实验配方

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Flunarizine 2HCl/盐酸氟桂利嗪 Catalog No. CSN11028

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