生物活性

• 描述Forodesine hydrochloride is an orally bioavailable PNP inhibitor with picomolar potency and induces apoptosis, mainly in T cells.
• 临床研究

• NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
  NCT00073944	Cancer	Phase 1	Completed	-	United States, Ohio ... more >> Cleveland Clinic Taussig Cancer Center Cleveland, Ohio, United States, 44195 Collapse <<
  NCT00061880	Lymphoma	Phase 1 Phase 2	Completed	-	United States, Alabama ... more >> University of Alabama at Birmingham Comprehensive Cancer Center Birmingham, Alabama, United States, 35294-3300 United States, North Carolina Duke Comprehensive Cancer Center Durham, North Carolina, United States, 27710 United States, Texas University of Texas - MD Anderson Cancer Center Houston, Texas, United States, 77030-4009 Collapse <<
  NCT01776411	Recurrent or Refractory PTCL	Phase 1 Phase 2	Completed	-	Japan ... more >> National Hospital Organization Nagoya Medical Center Nagoya, Aichi, Japan, 460-0001 Nagoya Daini Red Cross Hospital Nagoya, Aichi, Japan, 466-8650 National Cancer Center Hospital East Kashiwa, Chiba, Japan, 277-8577 National Hospital Organization Shikoku Cancer Center Matsuyama, Ehime,, Japan, 791-0280 Gunma University Hospital Maebashi, Gunma, Japan, 371-8511 National Hospital Organization Hokkaido Cancer Center Sapporo, Hokkaido, Japan, 003-0804 Hyogo Cancer Center Akashi, Hyogo, Japan, 673-8558 Tokai University Hospital Isehara, Kanagawa, Japan, 259-1143 Tohoku University Hospital Sendai, Miyagi, Japan, 980-8574 Osaka University Hospital Suita, Osaka, Japan, 565-0871 Shimane University Hospital Izumo, Shimane, Japan, 693-8501 Tochigi Cancer Center Utsunomiya, Tochigi, Japan, 320-0834 National Cancer Center Hospital Chuo, Tokyo, Japan, 104-0045 The Cancer Institute Hospital Japanese Foundation for Cancer Research Koto, Tokyo, Japan, 135-8550, University of Fukui Hospital Fukui, Japan, 910-1193 National Hospital Organization Kyushu Cancer Center Fukuoka, Japan, 811-1395 Fukuoka University Hospital Fukuoka, Japan, 814-0180 Imamura Bun-in Hospital Kagoshima, Japan, 890-0064 National Hospital Organization Kumamoto Medical Center Kumamoto, Japan, 860-0008 University Hospital, Kyoto Prefectural University of Medicine Kyoto, Japan, 602-8566 Okayama University Hospital Okayama,, Japan, 700-8558 Collapse <<

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• 参考文献

• [1] Ogura M, Tsukasaki K, et al. Phase I study of BCX1777 (forodesine) in patients with relapsed or refractory peripheral T/natural killer-cell malignancies. Cancer Sci. 2012 Jul;103(7):1290-5.

  [2] Homminga I, Zwaan CM, et al. In vitro efficacy of forodesine and nelarabine (ara-G) in pediatric leukemia. Blood. 2011 Aug 25;118(8):2184-90.