CAS No.: 1232030-35-1
FRAX486 Catalog No. CSN17596
Synonyms: N/A
FRAX486 is a selective inhibitor of group I PAKs with IC50s of 8.25/39.5, /55.3 nM for PAK1/PAK2/PAK3 respectivelt and less potent for PAK4 (IC50=779 nM).
| 规格 | 价格 | 促销价格 | 库存 | 数量 |
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纯度 & 质量文件
批次:
靶点选择性
生物活性
靶点 PAK2
IC50:39.5nMPAK3
IC50:55.3nMPAK4
IC50:779nMPAK1
IC50:8.25nM- 描述
- 参考文献
- [1] Wang Y, Gratzke C, et al. P21-Activated Kinase Inhibitors FRAX486 and IPA3: Inhibition of Prostate Stromal Cell Growth and Effects on Smooth Muscle Contraction in the Human Prostate. PLoS One. 2016 Apr 12;11(4):e0153312.
- [2] Hayashi-Takagi A, Araki Y, et al. PAKs inhibitors ameliorate schizophrenia-associated dendritic spine deterioration in vitro and in vivo during late adolescence. Proc Natl Acad Sci U S A. 2014 Apr 29;111(17):6461-6.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 1232030-35-1 | 储存条件 |
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| 分子式 | C25H23Cl2FN6O | 运输 | 蓝冰 | |||||||
| 分子量 | 513.39 | 别名 | N/A | |||||||
| 溶解度 |
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动物实验配方 |
