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CAS No.: 524-30-1

Fraxin/秦皮苷 Catalog No. CSN11055

Synonyms: Fraxoside;Fraxetol 8-glucoside;Fraxetin-8-O-glucoside

Fraxin protects HUVECs from oxidative stress, enhances urate excretion partly by inhibiting mURAT1 or mGLUT9 in kidney of hyperuricemic mice. It is a natural product isolated and purified from the bark of Fraxinus brngeana DC..

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技术信息

生物活性

描述Fraxin, isolated from Acer tegmentosum, exert potent anti-oxidative stress action. Treatment with fraxin significantly lowered the serum levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in a CCl₄-induced hepatotoxicity rat model. In the fraxin-treated group, glutathione (GSH) significantly increased, while the malondialdehyde (MDA) in the liver significantly decreased. Fraxin also showed radical-scavenging activity. Fraxin protected HepG2 cells through Nrf2 pathway-dependent HO-1 expression^[3]. Fraxin showed free radical scavenging effect at high concentration (0.5 mM) and cell protective effect against H2O2-mediated oxidative stress. Fraxin recovered viability of HUVECs damaged by H2O2-treatment and reduced the lipid peroxidation and the internal reactive oxygen species level elevated by H2O2 treatment^[4]. Fraxin reduced LPS-induced TNF-α, IL-6 and IL-1β production in A549 cells and alleviated the LPS-induced wet/dry (W/D) weight ratio and the effects observed via histopathological examination of the lung in vivo. Furthermore, fraxin reduced the protein concentrations in the broncho-alveolar lavage (BAL) fluid and cytokine production in the sera. Fraxin played a protective role in LPS-induced lung injury by inhibiting the NF-κB and NLRP3 signalling pathways^[5]. Fraxin elicited protective effects on mice with LPS-induced ARDS (Acute respiratory distress syndrome) and might be used as a drug to cure ARDS induced by Gram-negative bacterial infection^[6].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.7005 mL
- 13.5023 mL
- 27.0045 mL
- 5 mM
- 0.5401 mL
- 2.7005 mL
- 5.4009 mL
- 10 mM
- 0.2700 mL
- 1.3502 mL
- 2.7005 mL

技术信息

CAS号

524-30-1

储存条件

粉末: Sealed in dry,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C16H18O10

运输

蓝冰

分子量

370.31

别名

Fraxoside;Fraxetol 8-glucoside;Fraxetin-8-O-glucoside;秦皮苷

溶解度

DMSO	74.0 mg/mL (199.8 mM)

动物实验配方

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