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CAS No.: 1953-04-4
Synonyms: 氢溴酸加兰他敏;Galantamine hydrobromide;加兰他敏氢溴酸盐
Galanthamine hydrobromide is a natural occuring AchE inhibitor with IC50 value of 410nM and allosteric potentiator at neuronal nAchRs, used for the treatment of cognitive decline in mild to moderate Alzheimer's disease and various other memory impairments.
生物活性
靶点 | AChE IC50:410nM |
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
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NCT00234637 | Alzheimer's Disease | Phase 4 | Completed | - | France ... more >> Département de Gérontologie Clinique Limoges, Cedex, France, 87042 Collapse << |
NCT02703636 | Mild to Moderate Alzheimer's D... more >>isease Collapse << | Phase 4 | Completed | - | Japan ... more >> Novartis Investigative Site Fukuoka-city, Fukuoka, Japan, 814-001 Novartis Investigative Site Fukuoka-city, Fukuoka, Japan, 814-0180 Novartis Investigative Site Aizuwakamatsu, Fukushima, Japan, 965-8585 Novartis Investigative Site Tsukuba-city, Ibaraki, Japan, 305-8576 Novartis Investigative Site Kita-gun, Kagawa, Japan, 761-0793 Novartis Investigative Site Sagamihara-city, Kanagawa, Japan, 252-5188 Novartis Investigative Site Kochi-city, Kochi, Japan, 780-0842 Novartis Investigative Site Kurashiki-city, Okayama, Japan, 710-0826 Novartis Investigative Site Osaka-city, Osaka, Japan, 543-8555 Novartis Investigative Site Suita-city, Osaka, Japan, 565 0871 Novartis Investigative Site Kasukabe-city, Saitama, Japan, 344-0036 Novartis Investigative Site Koshigaya-city, Saitama, Japan, 343-0032 Novartis Investigative Site Fuji-city, Shizuoka, Japan Novartis Investigative Site Bunkyo-ku, Tokyo, Japan, 113-8431 Novartis Investigative Site Hachioji-city, Tokyo, Japan, 193-0944 Novartis Investigative Site Shinjuku-ku, Tokyo, Japan, 160-0023 Novartis Investigative Site Niigata, Japan Novartis Investigative Site Okayama, Japan, 710-0813 Novartis Investigative Site Tokyo, Japan, 168-8535 Collapse << |
NCT00814801 | - | - | Completed | - | - |
实验方案
技术信息
CAS号 | 1953-04-4 | 储存条件 |
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分子式 | C17H22BrNO3 | 运输 | 蓝冰 | |||||
分子量 | 368.27 | 别名 | 氢溴酸加兰他敏;Galantamine hydrobromide;加兰他敏氢溴酸盐 | |||||
溶解度 |
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动物实验配方 |
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
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NCT00234637 | Alzheimer's Disease | Phase 4 | Completed | - | France ... more >> Département de Gérontologie Clinique Limoges, Cedex, France, 87042 Collapse << |
NCT02703636 | Mild to Moderate Alzheimer's D... more >>isease Collapse << | Phase 4 | Completed | - | Japan ... more >> Novartis Investigative Site Fukuoka-city, Fukuoka, Japan, 814-001 Novartis Investigative Site Fukuoka-city, Fukuoka, Japan, 814-0180 Novartis Investigative Site Aizuwakamatsu, Fukushima, Japan, 965-8585 Novartis Investigative Site Tsukuba-city, Ibaraki, Japan, 305-8576 Novartis Investigative Site Kita-gun, Kagawa, Japan, 761-0793 Novartis Investigative Site Sagamihara-city, Kanagawa, Japan, 252-5188 Novartis Investigative Site Kochi-city, Kochi, Japan, 780-0842 Novartis Investigative Site Kurashiki-city, Okayama, Japan, 710-0826 Novartis Investigative Site Osaka-city, Osaka, Japan, 543-8555 Novartis Investigative Site Suita-city, Osaka, Japan, 565 0871 Novartis Investigative Site Kasukabe-city, Saitama, Japan, 344-0036 Novartis Investigative Site Koshigaya-city, Saitama, Japan, 343-0032 Novartis Investigative Site Fuji-city, Shizuoka, Japan Novartis Investigative Site Bunkyo-ku, Tokyo, Japan, 113-8431 Novartis Investigative Site Hachioji-city, Tokyo, Japan, 193-0944 Novartis Investigative Site Shinjuku-ku, Tokyo, Japan, 160-0023 Novartis Investigative Site Niigata, Japan Novartis Investigative Site Okayama, Japan, 710-0813 Novartis Investigative Site Tokyo, Japan, 168-8535 Collapse << |
NCT00814801 | - | - | Completed | - | - |
NCT01944436 | - | - | Completed | - | Canada, Ontario ... more >> Sunnybrook Health Sciences Centre Toronto, Ontario, Canada, M4N3M5 Collapse << |
NCT00551161 | Alzheimer Disease | Phase 4 | Completed | - | United States, New York ... more >> The Litwin-Zucker Research Center Manhasset, New York, United States, 11030 Collapse << |
NCT00283725 | - | - | Completed | - | - |
NCT02187276 | - | - | Completed | - | - |
NCT00551161 | - | - | Completed | - | - |
NCT00626613 | Dementia Alzh... more >>eimer's Disease Collapse << | Phase 4 | Unknown | - | Taiwan ... more >> Department of Psychiatry Jinan Mental Hospital Tainan, Taiwan, 717 Collapse << |
NCT01362686 | Dementia Alzh... more >>eimer's Disease Collapse << | Not Applicable | Terminated(Low study accrual c... more >>aused the study to be ended early.) Collapse << | - | United States, Indiana ... more >> Touchpoint Fishers, Indiana, United States, 46037 Methodist Center for Geriatric Medicine Indianapolis, Indiana, United States, 46202 University Clinical Neurology Indianapolis, Indiana, United States, 46202 Wishard Health Services Indianapolis, Indiana, United States, 46202 St. Vincent Center for Healthy Aging Indianapolis, Indiana, United States, 46260 Collapse << |
NCT01362686 | - | - | Terminated(Low study accrual c... more >>aused the study to be ended early.) Collapse << | - | - |
NCT03454646 | Alzheimer Disease ... more >> Cholinesterase Inhibitors Collapse << | Phase 4 | Not yet recruiting | September 15, 2021 | France ... more >> CHU d'Amiens Centre Mémoire Ressources Recherche Not yet recruiting Amiens, France, 80054 Contact: Agnès DEVENDEVILLE 03.22.66.82.40 devendeville.agnes@chu-amiens.fr CHU d'Angers Centre Mémoire Ressources Recherche Angers, France, 49933 CHU de Bastia Centre Mémoire Ressources Recherche Not yet recruiting Bastia, France, 20604 Contact: Georges RETTALI 04.95.59.18.32 georges.retali@ch-bastia.fr CHU de Besançon Centre Mémoire Ressources Recherche Besançon, France, 25030 CHU de Bordeaux - Service de Neurologie - Centre Mémoire Ressources Recherche - Not yet recruiting Bordeaux, France, 33076 Contact: Jean-François DARTIGUES 0557820116 jean-françois.dartigues@u-bordeaux.fr CHRU Cavale Blanche Service de Gériatrie Brest, France, 29200 Service de Neuropsychologie Hôpital Neurologique Pierre Wertheimer Not yet recruiting Bron, France, 69677 Contact: Hélène MOLLION 04.72.35.71.79 helene.mollion@chu-lyon.fr CHU Côte de Nacre Service de neurologie et CMRR Caen, France, 14033 CHU de Clermont Ferrand Centre Mémoire Ressources Recherche Clermont-Ferrand, France, 63000 Hôpital Pasteur Service de Neurologie Colmar, France, 68000 CHU de Dijon- CMRR Not yet recruiting Dijon, France, 21679 Contact: Yannick BEJOT 03.80.29.58.03 yannick.bejot@chu-dijon.fr Chu de Grenoble CMRR, Neurologie Not yet recruiting Grenoble, France, 38043 Contact: Olivier MOREAUD 04 76 76 57 90 omoreaud@chu-grenoble.fr Hôpital Roger Salengro CMRR Lille, France, 59037 CHU Limoges Service de neurologie et CMRR Not yet recruiting Limoges, France, 87000 Contact: Leslie CARTZ-PIVER 05.55.43.12.15 Lcp.coglim@gmail.com AP-HM Marseille, France CHU Montpellier Hôpital Gui de Chauliac CMRR Not yet recruiting Montpellier, France, 34295 Contact: Audrey GABOREAU DE LOUSTAL 04.67.33.60.29 a-gabelle@chu-montpellier.fr CHU de Nantes Clinique Neurologique Hôpital GR Laennec Not yet recruiting Nantes, France, 44093 Contact: Claire BOUTOLEAU 02.40.16.54.22 claire.boutoleaubretonniere@chu-nantes.fr Institut Claude Pompidou Centre Mémoire de Ressources et de Recherche Not yet recruiting Nice, France, 06100 Contact: Renaud David 04.92.03.47.70 claire.paquet@inserm.fr APHP Hôpital Broca Not yet recruiting Paris, France, 75013 Contact: Olivier HANON 01.44.08.35.03 olivier.hanon@brc.aphp.fr Hôpital Universitaire de la Pitié Salpêtrière Pavillon François Lhermitte Not yet recruiting Paris, France, 75013 Contact: Stéphane EPELBAUM 01.42.16.75.22 stephane.epelbaum@psl.aphp.fr APHP Groupe Hospitalier Saint Louis Lariboisière Fernand Widal CMRR Not yet recruiting Paris, France, 75475 Contact: Claire PAQUET 01.40.05.49.54 claire.paquet@inserm.fr CHU La Milétrie Pôle de Gériatrie Not yet recruiting Poitiers, France, 86021 Contact: Marc PACCALIN 05.49.44.44.27 m.paccalin@chu-poitiers.fr CHU Reims Hôpital Maison Blanche Court Séjour Gériatrique Not yet recruiting Reims, France, 51092 Contact: Jean-Luc NOVELLA 03.26.78.44.10 jl.novella@chu-reims.fr CHU de Rennes - Hôpital Pontchaillou / Service de Neurologie Not yet recruiting Rennes, France, 35033 Contact: Serge BELLIARD 02.99.87.30.26 serge.belliard@chu-rennes.fr CHU de Rouen Hôpital Charles Nicolle Service Neurologie Not yet recruiting Rouen, France, 76031 Contact: David Wallon 06.08.97.29.59 david.wallon@chu-rouen.fr Chu de Saint-Etienne, CMRR Not yet recruiting Saint-Étienne, France, 42055 Contact: Isabelle ROUCH 04.77.12.73.98 isabelle.rouch@chu-st-etienne.fr Chu de Strasbourg Hôpital Ka Robertsau Pôle de Gériatrie - CMRR Not yet recruiting Strasbourg, France, 67200 Contact: Frédéric BLANC 03.88.12.86.38 frederic.blanc@chru-strasbourg.fr Centre de Recherche Clinique du Gérontopôle Cité de la Santé Toulouse, France CHRU de Bretonneau Unité de gérontopsychiatrie Not yet recruiting Tours, France, 37000 Contact: Thomas DESMIDT 06.68.07.97.06 t.desmidt@chu-tours.fr CHU Nancy Service de Gériatrie-CMRR Not yet recruiting Vandoeuvre les nancy, France, 54511 Contact: Thérèse RIVASSEAU JONVAUX 03.83.15.35.71 t.jonveaux@chu-nancy.fr Hospice Civil de Lyon Hôpital des Charpennes Not yet recruiting Villeurbanne, France, 69100 Contact: Pierre KROLAK SALMON 04.72.43.20.50 pierre.krolak-salmon@chu-lyon.fr Collapse << |
NCT00637442 | Alzheimer's Disease | Not Applicable | Unknown | - | Germany ... more >> Department of Psychiatry, University Bonn Bonn, Germany, 53127 Collapse << |
NCT01529619 | Alzheimer's Disease | Phase 4 | Completed | - | Japan ... more >> Novartis Investigative Site Nagoya-city, Aichi, Japan, 467-8602 Novartis Investigative Site Fukuoka-city, Fukuoka, Japan, 814-0180 Novartis Investigative Site Miyoshi-city, Hiroshima, Japan, 728-0013 Novartis Investigative Site Ohtake, Hiroshima, Japan, 739-0696 Novartis Investigative Site Kita-gun, Kagawa, Japan, 761-0793 Novartis Investigative Site Kamakura-city, Kanagawa, Japan, 247-8533 Novartis Investigative Site Kawasaki-city, Kanagawa, Japan, 216-8511 Novartis Investigative Site Yokohama, Kanagawa, Japan, 241-0811 Novartis Investigative Site Koshi-city, Kumamoto, Japan, 861-1116 Novartis Investigative Site Kyoto-city, Kyoto, Japan, 600-8558 Novartis Investigative Site Kyoto, Japan, 606-0851 Collapse << |
NCT01845961 | Treatment-seeking Smokers, Rep... more >>orting Consumption of at Least 10 Cigarettes Per Day for at Least the Past 6 Months Collapse << | Phase 2 | Unknown | - | United States, Pennsylvania ... more >> Abramson Cancer Center of the University of Pennsylvania Recruiting Philadelphia, Pennsylvania, United States, 19104 Contact: Rebecca Ashare, PhD 855-216-0098 PennCancerTrials@emergingmed.com Collapse << |
NCT03124355 | Postural Tachycardia Syndrome | Phase 1 | Recruiting | December 2020 | United States, Tennessee ... more >> Autonomic Dysfunction Center/ Vanderbilt University Medical Center Recruiting Nashville, Tennessee, United States, 37232 Contact: Misty Hale, CCRP 615-322-2931 misty.hale@vanderbilt.edu Sub-Investigator: Bonnie K Black, RN Sub-Investigator: Luis E Okamoto, MD Sub-Investigator: David Robertson, MD Principal Investigator: Italo Biaggioni, MD Sub-Investigator: Alfredo Gamboa, MD Sub-Investigator: Cyndya A Shibao, MD Sub-Investigator: Andre Diedrich, MD, PhD Sub-Investigator: jorge Celedonio, MD Collapse << |
NCT02035982 | Alzheimer's Disease ... more >> Dementia Collapse << | Phase 3 | Completed | - | Canada, Ontario ... more >> North York General Hospital Toronto, Ontario, Canada, M2K1E1 Sunnybrook Health Sciences Centre Toronto, Ontario, Canada, M4N 3M5 Collapse << |
NCT01880099 | Nicotine Dependence | Not Applicable | Completed | - | United States, Connecticut ... more >> Veteran Affairs West Haven, Connecticut, United States, 06516 Collapse << |
NCT00181636 | Bipolar Disorder | Not Applicable | Completed | - | United States, Massachusetts ... more >> MGH Bipolar Clinic and Research Program Boston, Massachusetts, United States, 02114 Collapse << |
NCT01921972 | Alzheimer's Disease | Phase 4 | Completed | - | - |
NCT02365285 | Obesity | Phase 1 Phase 2 | Recruiting | October 2018 | United States, Tennessee ... more >> Vanderbilt University Medical Center Recruiting Nashville, Tennessee, United States, 37232 Contact: Cyndya Shibao, MD cyndya.shibao@vanderbilt.edu Contact: Keisha Card, RN keisha.d.card@vanderbilt.edu Collapse << |
NCT03014323 | Insulin Sensitivity ... more >> Oxidative Stress Collapse << | Phase 1 | Withdrawn(No fundings) | December 2018 | United States, Tennessee ... more >> Cyndya Shibao Nashville, Tennessee, United States, 37027 Collapse << |
NCT02098824 | Mild Cognitive Impairment (Vas... more >>cular) Mild Cognitive Disorder (Vascular) Vascular Dementia Collapse << | Phase 2 Phase 3 | Unknown | July 2017 | Netherlands ... more >> VU University Medical Center Recruiting Amsterdam, Netherlands, 1081 HV Contact: Niels D Prins, MD, PhD +20 3017170 nd.prins@vumc.nl Sub-Investigator: Jolien F Leijenaar, MD, MSc Collapse << |
NCT00369603 | Alzheimer's Disease | Phase 4 | Terminated(Reduced access to A... more >>chEI medication-naive mild AD patients.) Collapse << | - | United States, North Carolina ... more >> Joseph & Kathleen Bryan Alzheimer's Disease Research Unit Durham, North Carolina, United States, 27705 Collapse << |
NCT01531153 | Addiction | Not Applicable | Completed | - | United States, Connecticut ... more >> Department of Veterans Affairs West Haven, Connecticut, United States, 06516 Collapse << |
NCT00523666 | Alzheimer's Disease | Phase 4 | Unknown | September 2008 | Germany ... more >> Ludwig-Maximilian University of Munich Recruiting Munich, Germany, D-80336 Principal Investigator: Stefan Teipel, MD Sub-Investigator: Djyldyz Sydykova, MD Collapse << |
NCT01880099 | - | - | Completed | - | - |
NCT01416948 | Posttraumatic Stress Disorder ... more >> Traumatic Brain Injury Collapse << | Phase 2 | Terminated(The funding agency,... more >> DoD, determined that the study could not meet its enrollment numbers by the end of the grant.) Collapse << | - | United States, California ... more >> VA San Diego Healthcare System San Diego, California, United States, 92161 United States, Massachusetts Spaulding Rehabilitation Hospital Boston, Massachusetts, United States, 02114 United States, New Hampshire Manchester VA Medical Center Manchester, New Hampshire, United States, 03104 United States, North Carolina Duke University Durham, North Carolina, United States, 27710 United States, Ohio University of Cincinnati Cincinnati, Ohio, United States, 45219 United States, South Carolina Ralph H. Johnson VA Medical Center Charleston, South Carolina, United States, 29401 United States, Vermont White River Junction VA Medical Center White River Junction, Vermont, United States, 05009 Collapse << |
NCT00219869 | Post-Traumatic Headache ... more >> Head Trauma,Closed Retention Disorders,Cognitive Collapse << | Phase 4 | Unknown | - | United States, Connecticut ... more >> The New England Center for Headache Recruiting Stamford, Connecticut, United States, 06902 Contact: Lori Flanagan, RN 203-322-2748 lc@nech.net Contact: Kathy Diomede 203-322-2748 kd@nech.net Principal Investigator: Alan Rapoport, MD Sub-Investigator: Stewart Tepper, MD Sub-Investigator: Fred Sheftell, MD Sub-Investigator: Marcelo Bigal, MD, PhD Collapse << |
NCT00035191 | Dementia, Vascular | Phase 3 | Completed | - | - |
NCT00423969 | Depression | Phase 4 | Terminated | - | United States, Indiana ... more >> IU Adult Psychiatric Clinic Indianapolis, Indiana, United States, 46202 Collapse << |
NCT00000172 | Alzheimer Disease | Phase 3 | Completed | - | - |
NCT00509067 | Schizophrenia | Phase 2 | Completed | - | United States, District of Col... more >>umbia Washington Veterans Affairs Medical Center Washington, District of Columbia, United States, 20422 Collapse << |
NCT00077727 | Schizophrenia | Phase 3 | Completed | - | - |
NCT01531153 | - | - | Completed | - | - |
NCT00301574 | Alzheimer Disease | Phase 3 | Completed | - | - |
NCT00227994 | - | - | Completed | - | - |
NCT00176423 | Schizophrenia ... more >> Schizoaffective Disorder Collapse << | Phase 4 | Completed | - | United States, Maryland ... more >> Maryland Psychiatric Research Center Baltimore, Maryland, United States, 21228 Collapse << |
NCT00161044 | Chronic Schizophrenia | Not Applicable | Completed | - | United States, Maryland ... more >> Maryland Psychiatric Research Center Catonsville, Maryland, United States, 21228 Collapse << |
NCT00509067 | - | - | Completed | - | - |
NCT00211588 | Parkinson's Disease | Not Applicable | Unknown | May 2007 | United States, Rhode Island ... more >> Memorial Hospital of RI Pawtucket, Rhode Island, United States, 02860 Collapse << |
NCT00240695 | Cognition Disorder ... more >> Nervous System Diseases Mental Disorders Brain Diseases Collapse << | Phase 3 | Completed | - | - |
NCT00227994 | Cerebrovascular Accident | Phase 4 | Completed | - | United States, Pennsylvania ... more >> University of Pittsburgh Medical Center Pittsburgh, Pennsylvania, United States, 15260 Collapse << |
NCT00253188 | Alzheimer Disease ... more >> Dementia Collapse << | Phase 3 | Completed | - | - |
NCT00309725 | Alzheimer's Disease | Phase 3 | Completed | - | - |
NCT00253201 | Alzheimer Disease ... more >> Dementia Collapse << | Phase 3 | Completed | - | - |
NCT00226824 | Tourette's Syndrome ... more >> Motor Tic Disorder Vocal Tic Disorder Collapse << | Phase 4 | Terminated(Unable to recruit s... more >>ubjects into the trial.) Collapse << | - | United States, New York ... more >> Parkinson's Disease and Movement Disorders Center of Albany Medical Center Albany, New York, United States, 12205 Collapse << |
NCT00216502 | Alzheimer Disease ... more >> Dementia Mental Disorders Brain Diseases Collapse << | Phase 3 | Completed | - | - |
NCT00253214 | Alzheimer Disease ... more >> Dementia Collapse << | Phase 3 | Completed | - | - |
NCT00320736 | Schizophrenia ... more >> Schizoaffective Disorder Collapse << | Phase 4 | Completed | - | United States, Massachusetts ... more >> Freedom Trail Clinic Boston, Massachusetts, United States, 02114 Collapse << |
NCT00216593 | Dementia Alzh... more >>eimer Disease Collapse << | Phase 3 | Completed | - | - |
NCT01194336 | - | - | Completed | - | United States, Maryland ... more >> Walter Reed Army Institute of Research Silver Spring, Maryland, United States, 20910 Collapse << |
NCT00236574 | Dementia Alzh... more >>eimer Disease Collapse << | Phase 3 | Completed | - | - |
NCT00216515 | Alzheimer Disease | Phase 4 | Completed | - | - |
NCT00230997 | Lewy Body Disease | Phase 3 | Completed | - | United States, Indiana ... more >> Indiana University for AD and Related Disorders Indianapolis, Indiana, United States, 46202 United States, New York Buffalo Insititute for Medical Research Buffalo, New York, United States, 14215 United States, Pennsylvania Alzheimer's Center of Pittsburgh Pittsburgh, Pennsylvania, United States, 15205 United States, Texas UTHSCSA Psychiatry Department San Antonio, Texas, United States, 78229-3900 United States, Vermont Neurological Research Center, Inc. Bennington, Vermont, United States, 05201 Collapse << |
NCT00252603 | Autism Childh... more >>ood Autism Collapse << | Phase 3 | Completed | - | United States, New Jersey ... more >> UMDNJ Robert Wood Johnson Medical School - Dept of Psychiatry Piscataway, New Jersey, United States, 08854 Collapse << |
NCT00463879 | Schizophrenia | Phase 2 Phase 3 | Completed | - | United States, Connecticut ... more >> Connecticut Mental Health Center, Yale School of Medicine New Haven, Connecticut, United States, 06519 Collapse << |
NCT00304629 | Alzheimer Disease | Phase 3 | Completed | - | - |
NCT00181675 | ADHD | Phase 4 | Completed | - | United States, Massachusetts ... more >> Massachusetts General Hospital Cambridge, Massachusetts, United States, 02138 Collapse << |
NCT00236431 | Dementia Alzh... more >>eimer Disease Collapse << | Phase 3 | Completed | - | - |
NCT00164242 | Tardive Dyskinesia | Phase 4 | Completed | - | United States, Pennsylvania ... more >> Philadelphia VA Medical Center Philadelphia, Pennsylvania, United States, 19104 Collapse << |
NCT00082602 | Alzheimer's Disease | Phase 3 | Completed | - | - |
NCT00195845 | Bipolar Disorder | Phase 4 | Completed | - | United States, Massachusetts ... more >> Cambridge Health Alliance Cambridge, Massachusetts, United States, 02139 Collapse << |
NCT00253227 | Alzheimer Disease ... more >> Dementia Collapse << | Phase 3 | Completed | - | - |
NCT00338117 | Alzheimer's Disease ... more >> Dementia Collapse << | Phase 3 | Completed | - | - |
NCT00814801 | Alzheimer's Disease | Phase 3 | Completed | - | Japan ... more >> Fukuoka, Japan Collapse << |
NCT00750529 | Alzheimer's Disease | Phase 1 | Completed | - | France ... more >> CHU Clermont-Ferrand Clermont-Ferrand, France, 63003 CPC-CIC Clermont-Ferrand, France, 63003 Collapse << |
NCT00261573 | Alzheimer Disease ... more >> Vascular Dementia Collapse << | Phase 3 | Completed | - | - |
NCT00297362 | - | - | Completed | - | - |
NCT01009476 | - | - | Completed | - | - |
NCT02872857 | Subarachnoid Hemorrhage | Phase 1 Phase 2 | Recruiting | September 2019 | United States, Texas ... more >> The University of Texas Health Science Center at Houston Recruiting Houston, Texas, United States, 77030 Contact: Huimahn Choi, MD, MS 713-500-5638 Huimahn.A.Choi@uth.tmc.edu Collapse << |
NCT02420327 | Basic Science Study of the Mec... more >>hanisms of Attentional Enhancement by Compounds Acting on the Nicotinic Receptor Collapse << | Not Applicable | Completed | - | United States, Maryland ... more >> University of Maryland School of Medicine, Maryland Psychiatric Research Center Catonsville, Maryland, United States, 21228 Collapse << |
NCT02420327 | - | - | Completed | - | - |
NCT00035204 | Alzheimer Disease | Phase 4 | Completed | - | - |
NCT00814658 | - | - | Completed | - | - |
NCT00679627 | Alzheimer's Disease | Phase 3 | Terminated(Due to a pre-specif... more >>ied imbalance of deaths between treatment groups, the DSMB recommended early termination of the trial) Collapse << | - | - |
NCT00416169 | Frontotemporal Dementia ... more >> Pick Complex Collapse << | Phase 2 | Completed | - | - |
NCT00679627 | - | - | Terminated(Due to a pre-specif... more >>ied imbalance of deaths between treatment groups, the DSMB recommended early termination of the trial) Collapse << | - | - |
NCT01181921 | Alzheimer Disease | Phase 4 | Terminated(The recruitment rat... more >>e was very low (one screening failure and one early withdrawal patient)) Collapse << | - | Spain ... more >> Barcelona, Spain Collapse << |
NCT00814658 | Dementia | Phase 4 | Completed | - | - |
NCT01478633 | Alzheimer's Disease | Phase 4 | Completed | - | Japan ... more >> Akita, Japan Izunokuni, Japan Kochi N/A, Japan Kumamoto, Japan Osaka, Japan Saitama N/A, Japan Takatsuki, Japan Tokyo, Japan Uji, Japan Urayasu, Japan Yokohama, Japan Collapse << |
NCT02283242 | Abdominal Obesity Metabolic Sy... more >>ndrome Collapse << | Phase 4 | Completed | - | Brazil ... more >> University of São Paulo, Heart Institute, Medical School São Paulo, Brazil, 05403-900 Collapse << |
NCT01012167 | Schizophrenia | Phase 2 | Completed | - | United States, Maryland ... more >> Baltimore VA Medical Center Baltimore, Maryland, United States, 21201 Community Mental Health Centers Baltimore, Maryland, United States, 21201 Keypoint Community Mental Health Centers Baltimore, Maryland, United States, 21222 Maryland Psychiatric Research Center Baltimore, Maryland, United States, 21228 Maryland Psychiatric Research Center Catonsville, Maryland, United States, 21228 Keypoint Mental health Center Dundalk, Maryland, United States, 21222 Collapse << |
NCT00297414 | - | - | Completed | - | - |
NCT01508494 | Stroke Cognit... more >>ive Impairment Collapse << | Phase 2 | Unknown | November 2017 | France ... more >> Service de Neurologie, CHU Toulouse Purpan Recruiting Toulouse, France, 31059 Contact: Jérémie Pariente, Md +33 (0)5 61 77 76 86 jeremie.pariente@inserm.fr Principal Investigator: Jérémie Pariente, MD Collapse << |
NCT01029132 | Dementia | Not Applicable | Completed | - | Korea, Republic of ... more >> Samsung Medical Center Seoul, Korea, Republic of, 135-710 Collapse << |
NCT00645554 | Pharmacokinetics | Phase 1 | Completed | - | - |
NCT03547622 | Methadone or Buprenorphine Det... more >>oxoxification Collapse << | Early Phase 1 | Recruiting | May 2019 | United States, Connecticut ... more >> APT Foundation Recruiting New Haven, Connecticut, United States, 06511 Collapse << |
NCT01012167 | - | - | Completed | - | - |
NCT00969696 | Memory | Phase 1 | Completed | - | United States, Connecticut ... more >> Department of Veterans Affairs West Haven, Connecticut, United States, 06516 Collapse << |
NCT01181921 | - | - | Terminated(The recruitment rat... more >>e was very low (one screening failure and one early withdrawal patient)) Collapse << | - | - |
NCT01669538 | Tobacco Use Disorder | Phase 2 | Completed | - | United States, Pennsylvania ... more >> Center for Interdisciplinary Research on Nicotine Addiction, University of Pennsylvania Philadelphia, Pennsylvania, United States, 19104 Collapse << |
NCT00645190 | Alzheimer Disease | Phase 3 | Completed | - | - |
NCT03384784 | HIV Associated Cognitive Motor... more >> Complex Collapse << | Phase 2 | Recruiting | May 2022 | United States, Pennsylvania ... more >> Center for Interdisciplinary Research on Nicotine Addiction, University of Pennsylvania Recruiting Philadelphia, Pennsylvania, United States, 19104 Contact: Molly R Ruben, MPH 215-746-8420 molly.ruben@pennmedicine.upenn.edu Contact: Kristin Tederstrom 215-746-7142 tederstr@pennmedicine.upenn.edu Collapse << |
NCT01054976 | - | - | Completed | - | - |
NCT00299676 | - | - | Completed | - | Australia ... more >> Auckland, Australia Christchurch Nz, Australia Hamilton, Australia Porirua, Australia Tauranga, Australia Collapse << |
NCT00232349 | Schizophrenia ... more >> Psychotic Disorder Collapse << | Phase 4 | Terminated(Study terminated du... more >>e to no apparent benefit.) Collapse << | - | United States, Washington ... more >> VA Puget Sound Health Care System, American Lake Division Tacoma, Washington, United States, 98493 Collapse << |
NCT00606801 | - | - | Completed | - | - |
NCT00809835 | Cocaine Dependence | Phase 2 | Completed | - | United States, Connecticut ... more >> Kinsella Treatment Center (KTC) Bridgeport, Connecticut, United States, 06604 Regional Network of Programs Stratford, Connecticut, United States, 06615 Collapse << |
NCT01054976 | Alzheimer's Disease | Phase 4 | Completed | - | - |
NCT01190748 | Healthy | Phase 1 | Completed | - | Canada, Quebec ... more >> SFBC Anapharm Sainte-Foy, Quebec, Canada, G 1 V 2K8 Collapse << |
NCT01129479 | Aphasia Strok... more >>e Collapse << | Not Applicable | Completed | - | - |
NCT00606801 | Cocaine Abuse | Not Applicable | Completed | - | United States, Connecticut ... more >> Veterans Affairs Hospital West Haven, Connecticut, United States, 06516 Collapse << |
NCT01190761 | Healthy | Phase 1 | Completed | - | Canada, Quebec ... more >> SFBC Anapharm Sainte-Foy, Quebec, Canada, G 1 V 2K8 Collapse << |
NCT00809835 | - | - | Completed | - | - |
NCT02234752 | Schizophrenia ... more >> Schizoaffective Disorder Collapse << | Phase 2 | Terminated(Funding no longer a... more >>vailable and PI no longer working at the institution) Collapse << | - | United States, Maryland ... more >> Sheppard Pratt Health System Baltimore, Maryland, United States, 21204 Collapse << |
NCT00741598 | - | - | Completed | - | - |
NCT00741598 | Bipolar Disorder | Phase 4 | Completed | - | United States, Massachusetts ... more >> Massachusetts General Hospital Boston, Massachusetts, United States, 02114 United States, New York Icahn School of Medicine at Mount Sinai New York, New York, United States, 10029 Collapse << |
NCT00566735 | Major Depression ... more >> Bipolar Depression Schizoaffective Disorder Collapse << | Phase 3 | Completed | - | United States, Massachusetts ... more >> Massachusetts General Hospital Boston, Massachusetts, United States, 02114 Collapse << |
NCT01039194 | Alzheimer Disease | Phase 1 | Completed | - | United States, Maryland ... more >> Parexel International - Baltimore Epcu Baltimore, Maryland, United States, 21225 Collapse << |
NCT01100775 | Schizophrenia | Phase 2 | Active, not recruiting | October 2018 | United States, Maryland ... more >> University of Maryland, Baltimore Baltimore, Maryland, United States, 21228 Collapse << |
NCT02234752 | - | - | Terminated(Funding no longer a... more >>vailable and PI no longer working at the institution) Collapse << | - | - |
NCT01372306 | Fed | Phase 1 | Completed | - | - |
NCT00566735 | - | - | Completed | - | - |
NCT01734395 | - | - | Completed | - | - |
NCT01417429 | Smoking Tobac... more >>co Withdrawal Collapse << | Phase 1 | Completed | - | United States, Connecticut ... more >> Department of Veterans Affairs West Haven, Connecticut, United States, 06516 Collapse << |
NCT01734395 | - | - | Completed | - | - |
NCT01548638 | - | - | Completed | - | - |
NCT01372280 | Fasting | Phase 1 | Completed | - | - |
NCT01548638 | Nicotine Addiction | Phase 2 | Completed | - | United States, Pennsylvania ... more >> Center for Interdisciplinary Research on Nicotine Addiction, School of Medicine, University of Pennsylvania Philadelphia, Pennsylvania, United States, 19104 Collapse << |
NCT00077727 | Schizophrenia | Phase 3 | Completed | - | - |
NCT00240695 | Cognition Disorder ... more >> Nervous System Diseases Mental Disorders Brain Diseases Collapse << | Phase 3 | Completed | - | - |
NCT01372280 | Fasting | Phase 1 | Completed | - | - |
NCT01372306 | Fed | Phase 1 | Completed | - | - |
NCT00645190 | Alzheimer Disease | Phase 3 | Completed | - | - |
NCT00181675 | ADHD | Phase 4 | Completed | - | United States, Massachusetts ... more >> Massachusetts General Hospital Cambridge, Massachusetts, United States, 02138 Collapse << |
NCT00566735 | Major Depression ... more >> Bipolar Depression Schizoaffective Disorder Collapse << | Phase 3 | Completed | - | United States, Massachusetts ... more >> Massachusetts General Hospital Boston, Massachusetts, United States, 02114 Collapse << |
NCT00416169 | Frontotemporal Dementia ... more >> Pick Complex Collapse << | Phase 2 | Completed | - | - |
NCT00566735 | - | - | Completed | - | - |
靶点 | Description | IC50 |
---|---|---|
AChE | IC50:410nM |
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