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CAS No.: 510-77-0

Galanthaminone Catalog No. CSN12443

Synonyms: (-)-Narwedine;Narwedin;Narwedine

Galantamine is a competitive and reversible cholinesterase (AChE) inhibitor and is used for the treatment of mild to moderate Alzheimer's disease and various other memory impairments.

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描述Galanthaminone (GAL) is a competitive and reversible cholinesterase (AChE) inhibitor; is used for the treatment of mild to moderate Alzheimer's disease and various other memory impairments^[3]. The inhibition of acetylcholinesterase activity was closely correlated with the pharmacokinetics of galanthamine, a median maximal value of 53% being achieved by applying 10 mg galanthamine intravenously. Analysis of in vitro and ex vivo concentration responses revealed no differences, indicating that no metabolites of galanthamine exert additional inhibition of acetylcholinesterase activity^[4]. In vivo, the maximal 36-55% inhibition of AChE was approached 30 min after oral administration of 10 mg GAL. The duration of the catalytic inhibition corresponded to an elimination half-life of approximately 5-7 h^[5]. Galanthamine plasma peaks (1.24 micrograms/ml after subcutaneous and 1.15 micrograms/ml after oral doses) were reached 2 h following administration, the t1/2(beta) values being 5.70 and 5.26 h, respectively. An almost complete urinary recovery of galanthamine and its metabolites was obtained within 72 h. The plasma AUC, Cmax, tmax and ka suggest that the subcutaneous and oral Nivalin formulations are bioequivalent^[6].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.5046 mL
- 17.5231 mL
- 35.0462 mL
- 5 mM
- 0.7009 mL
- 3.5046 mL
- 7.0092 mL
- 10 mM
- 0.3505 mL
- 1.7523 mL
- 3.5046 mL

技术信息

CAS号

510-77-0

储存条件

粉末: Sealed in dry,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C17H19NO3

运输

蓝冰

分子量

285.34

别名

(-)-Narwedine;Narwedin;Narwedine;3-Deoxy-3-oxo-galanthamine

溶解度

DMSO	10.0 mg/mL (35.0 mM) warming
Water	Insoluble

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