|Gap 26游离态|CsnPharm

CAS No.: 197250-15-0

Gap 26/Gap 26游离态 Catalog No. CSN23773

Synonyms: Gap 26 (trifluoroacetate salt);Gap Junction Peptide 26;VCYDKSFPISHVR

Gap 26, a mimetic peptide of connexin, is the gap junction blocker that corresponds to the residues 63-75 of connexin 43.

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靶点选择性

生物活性

实验方案

技术信息

生物活性

描述Gap 26 is a connexin mimetic peptide, working as a Gap junction blocker. Gap26 inhibited electrical coupling in cell pairs mediated by gap junctions after exposure for 30 min, but inhibited hemichannel currents evoked in low Ca²⁺ solution with a response time of less than 5 min when applied to single cells. Gap 26 reduced the size of InsP₃-triggered intercellular calcium waves at concentration of 0.25mg/ml post 30 minutes in RBE4 cells, blocked Photoliberating InsP₃ triggered ATP release, but did not inhibit the gap junctional coupling between the cells.
作用机制Gap 26 is a connexin mimetic peptide corresponding to short conserved extracellular loop sequences of connexins as reversible inhibitor of gap junctional intercellular communication.^[1]
动物研究
剂量
Mice: 5 mg/kg^[3] (i.t.); 1 μg/kg^[4] (i.v.)

给药途径
i.t., i.v.
参考文献

动物研究
剂量	Mice: 5 mg/kg^[3] (i.t.); 1 μg/kg^[4] (i.v.)
给药途径	i.t., i.v.

[1] Desplantez T, Verma V, et al. Gap26, a connexin mimetic peptide, inhibits currents carried by connexin43 hemichannels and gap junction channels. Pharmacol Res. 2012 May;65(5):546-52.
[2] Braet K, Vandamme W, et al. Photoliberating inositol-1,4,5-trisphosphate triggers ATP release that is blocked by the connexin mimetic peptide gap 26. Cell Calcium. 2003 Jan;33(1):37-48.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 0.6448 mL
- 3.2242 mL
- 6.4484 mL
- 5 mM
- 0.1290 mL
- 0.6448 mL
- 1.2897 mL
- 10 mM
- 0.0645 mL
- 0.3224 mL
- 0.6448 mL

技术信息

CAS号

197250-15-0

储存条件

粉末: Keep in dark place,Inert atmosphere,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C70H107N19O19S

运输

蓝冰

分子量

1550.78

别名

Gap 26 (trifluoroacetate salt);Gap Junction Peptide 26;VCYDKSFPISHVR

溶解度

DMSO	100.0 mg/mL (64.5 mM)
Ethanol	50.0 mg/mL (32.2 mM)

动物实验配方

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Gap 26/Gap 26游离态 Catalog No. CSN23773

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