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CAS No.: 180200-66-2

Gatifloxacin Sesquihydrate/加替沙星倍半水合物 Catalog No. CSN12490

Synonyms: AM-1155 sesquihydrate;BMS-206584 sesquihydrate;PD135432 sesquihydrate

Gatifloxacin Sesquihydrate is an antibiotic of the fourth-generation fluoroquinolone family.

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描述Gatifloxacin (Sesquihydrate) is an antibiotic of the fourth-generation fluoroquinolone family. Ophthalmic gatifloxacin 0.3% is at least as effective as ciprofloxacin at healing corneal ulcers infected with Pseudomonas aeruginosa when gatifloxacin is administered less frequently than ciprofloxacin^[3]. Gatifloxacin possessed potent activity (MIC, 0.39 microg/ml) against the NorA-overproducing strain S. aureus NY12, the norA transformant, which was slightly lower than that against the parent strain SA113^[4]. Ocular inserts of gatifloxacin were prepared successfully by using solvent casting method for sustained drug delivery. The cross-linked and Eudragit RL-100 coated ocular insert of gatifloxacin provides better in vitro drug release and sustained upto 11h^[2].
参考文献

[1] Pantel A, Petrella S, et al. Extending the definition of the GyrB quinolone resistance-determining region in Mycobacterium tuberculosis DNA gyrase for assessing fluoroquinolone resistance in M. tuberculosis. Antimicrob Agents Chemother. 2012 Apr;56(4):1990-6.
[2] Khurana G, Arora S, Pawar PK. Ocular insert for sustained delivery of gatifloxacin sesquihydrate: Preparation and evaluations. Int J Pharm Investig. 2012;2(2):70–77
[3] Jensen H, Zerouala C, Carrier M, Short B. Comparison of ophthalmic gatifloxacin 0.3% and ciprofloxacin 0.3% in healing of corneal ulcers associated with Pseudomonas aeruginosa-induced ulcerative keratitis in rabbits. J Ocul Pharmacol Ther. 2005;21(1):36–43
[4] Fukuda H, Hori S, Hiramatsu K. Antibacterial activity of gatifloxacin (AM-1155, CG5501, BMS-206584), a newly developed fluoroquinolone, against sequentially acquired quinolone-resistant mutants and the norA transformant of Staphylococcus aureus. Antimicrob Agents Chemother. 1998;42(8):1917–1922

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.2425 mL
- 6.2125 mL
- 12.4250 mL
- 5 mM
- 0.2485 mL
- 1.2425 mL
- 2.4850 mL
- 10 mM
- 0.1242 mL
- 0.6212 mL
- 1.2425 mL

技术信息

CAS号	180200-66-2		储存条件	粉末 Inert atmosphere,Room Temperature 液体 -20°C:3-6 月 -80°C:12月
分子式	C38H50F2N6O11		运输	蓝冰
分子量	804.83		别名	AM-1155 sesquihydrate;BMS-206584 sesquihydrate;PD135432 sesquihydrate;Bis(gatifloxacin)trihydrate;Gatifloxacin

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