CAS No.: 67469-81-2
GBR 12935 2HCl/GBR 12935 二盐酸盐 Catalog No. CSN17054
Synonyms: GBR 12935 (hydrochloride);GBR-12935
GBR 12935 2HCl is a potent and selective dopamine reuptake inhibitor with KD of 5.5 nM in rat striatal membranes.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 参考文献
- [1] Rahman S, Engleman E, et al. Negative interaction of dopamine D2 receptor antagonists and GBR 12909 and GBR 12935 dopamine uptake inhibitors in the nucleus accumbens. Eur J Pharmacol. 2001 Feb 23;414(1):37-44.
- [2] Hiroi T, Imaoka S, et al. Specific binding of 1-[2-(diphenylmethoxy)ethyl] -4-(3-phenyl propyl) piperazine (GBR-12935), an inhibitor of the dopamine transporter, to human CYP2D6. Biochem Pharmacol. 1997 Jun 15;53(12):1937-9.
- [3] Hiroi T, Imaoka S, Chow T, Yabusaki Y, Funae Y. Specific binding of 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenyl propyl) piperazine (GBR-12935), an inhibitor of the dopamine transporter, to human CYP2D6. Biochem Pharmacol. 1997 Jun 15;53(12):1937-9
- [4] Rahman S, Engleman E, Simon J, McBride WJ. Negative interaction of dopamine D2 receptor antagonists and GBR 12909 and GBR 12935 dopamine uptake inhibitors in the nucleus accumbens. Eur J Pharmacol. 2001 Feb 23;414(1):37-44
- [5] Tolliver BK, Carney JM. Comparison of cocaine and GBR 12935: effects on locomotor activity and stereotypy in two inbred mouse strains. Pharmacol Biochem Behav. 1994 Jul;48(3):733-9
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 67469-81-2 | 储存条件 |
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| 分子式 | C28H36Cl2N2O | 运输 | 蓝冰 | |||
| 分子量 | 487.50 | 别名 | GBR 12935 (hydrochloride);GBR-12935 | |||
| 溶解度 |
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动物实验配方 |
