CAS No.: 1282514-88-8
GDC-0326 Catalog No. CSN20187
Synonyms: CAS#1282514-88-8
GDC-0326 is a potent and selective inhibitor of α-Isoform of Phosphoinositide 3-Kinase (PI3Kalpha inhibitor). GDC-0326 achieves a very high level of selectivity over other kinases.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 参考文献
- [1] Soler A, Figueiredo AM, et al. Therapeutic Benefit of Selective Inhibition of p110α PI3-Kinase in Pancreatic Neuroendocrine Tumors. Clin Cancer Res. 2016 Dec 1;22(23):5805-5817.
- [2] Heffron TP, Heald RA, et al. The Rational Design of Selective Benzoxazepin Inhibitors of the α-Isoform of Phosphoinositide 3-Kinase Culminating in the Identification of (S)-2-((2-(1-Isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f] imidazo[1,2-d] [1,4] oxazepin-9-yl)oxy)propanamide (GDC-0326). J Med Chem. 2016 Feb 11;59(3):985-1002.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 1282514-88-8 | 储存条件 |
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| 分子式 | C19H22N6O3 | 运输 | 蓝冰 | |
| 分子量 | 382.42 | 别名 | CAS#1282514-88-8 |
