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CAS No.: 210353-53-0

Gemifloxacin Mesylate/甲磺酸吉米沙星 Catalog No. CSN11087

Synonyms: SB-265805S;LB-20304a;Gemifloxacin (mesylate)

Gemifloxacin mesylate is an oral broad-spectrum quinolone antibacterial agent, used in the treatment of acute bacterial exacerbation of chronic bronchitis, and mild-to-moderate pneumonia.

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技术信息

生物活性

描述Gemifloxacin mesylate (GFM) is a synthetic broad-spectrum antibacterial agent^[1]. Gemifloxacin is a fluoroquinolone antibacterial agent which has an enhanced affinity for topoisomerase IV. It has potent activity against most gram-positive bacteria, particularly streptococcus pneumoniae. Gemifloxacin is over 30-fold more active than ciprofloxacin and 4- to 8-fold more active than moxifloxacin against this pathogen. Gemifloxacin has excellent activity against Haemophilus influenzae and Moraxella catarrhalis, and is unaffected by beta-lactamase production. Atypical respiratory pathogens (Legionella, Mycoplasma and Chlamydia spp.) are highly susceptible to gemifloxacin. Oral gemifloxacin 320 mg/day produced bacteriological responses of 94.7% in patients with acute exacerbations of chronic bronchitis and 95% of patients with uncomplicated urinary tract infections^[3]. DTH (Delayed type hypersensitivity) assay has shown the significant immune suppressant potential of gemifloxacin at 25 mg/kg dose and 75mg/kg dose in mice^[4]. Gemifloxacin is microbiologically the most active fluoroquinolone against Streptococcus pneumoniae--the leading pathogen of CAP (community-acquired pneumonia)^[5].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT03535558	-	-	Recruiting	December 31, 2018	United States, New Jersey ... more >> Janssen Investigative Site Recruiting Titusville, New Jersey, United States, 08560 Collapse <<
NCT03479736	-	-	Completed	-	United States, New Jersey ... more >> Janssen Investigative Site Titusville, New Jersey, United States, 08560 Collapse <<
NCT01881438	-	-	Completed	-	-

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参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.0598 mL
- 10.2989 mL
- 20.5979 mL
- 5 mM
- 0.4120 mL
- 2.0598 mL
- 4.1196 mL
- 10 mM
- 0.2060 mL
- 1.0299 mL
- 2.0598 mL

技术信息

CAS号

210353-53-0

储存条件

粉末: Inert atmosphere,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C19H24FN5O7S

运输

蓝冰

分子量

485.49

别名

SB-265805S;LB-20304a;Gemifloxacin (mesylate);Gemifloxacin Mesylate;Factive;LB-20304;SB-265805;甲磺酸吉米沙星

溶解度

DMSO	95.0 mg/mL (195.7 mM) warming
Water	50.0 mg/mL (103.0 mM) warming

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NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT03535558	-	-	Recruiting	December 31, 2018	United States, New Jersey ... more >> Janssen Investigative Site Recruiting Titusville, New Jersey, United States, 08560 Collapse <<
NCT03479736	-	-	Completed	-	United States, New Jersey ... more >> Janssen Investigative Site Titusville, New Jersey, United States, 08560 Collapse <<
NCT01881438	-	-	Completed	-	-
NCT00926796	Gonorrhoea	Phase 4	Completed	-	United States, Alabama ... more >> University of Alabama Hospital - Infectious Diseases Birmingham, Alabama, United States, 35249-0001 United States, California Los Angeles County Department of Public Health - Sexually Transmitted Disease Program Los Angeles, California, United States, 90007-2608 San Francisco Department of Public Health - San Francisco City Clinic San Francisco, California, United States, 94103-4030 United States, Maryland Johns Hopkins Bayview Medical Center - Infectious Diseases Baltimore, Maryland, United States, 21224-2735 United States, Pennsylvania Magee Women's Hospital of UPMC - Reproductive Infectious Disease Research Pittsburgh, Pennsylvania, United States, 15213-3108 Collapse <<
NCT00926796	-	-	Completed	-	-
NCT03326050	Rhinoscleroma	Early Phase 1	Not yet recruiting	October 2018	Egypt ... more >> Asmaa Ahmed Enrolling by invitation Assiut, Egypt Collapse <<
NCT01879007	Infectious Diseases	Phase 1	Completed	-	Korea, Republic of ... more >> Asan medical center Seoul, Korea, Republic of Collapse <<
NCT02368470	Helicobacter Pylori Infection	Phase 3	Unknown	October 2015	Korea, Republic of ... more >> Samsung Medical Center Recruiting Seoul, Korea, Republic of Contact: Hyuk Lee, MD Collapse <<

Gemifloxacin Mesylate/甲磺酸吉米沙星 Catalog No. CSN11087

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