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CAS No.: 497833-27-9
Synonyms: ITF-2357;gavinostat
Givinostat is a potent HDAC inhibitor for Maize HD2, HD1-B and HD1-A with IC50 of 10 nM, 7.5 nM and 16 nM,respectively.
生物活性
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
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NCT00792467 | Hodgkin's Lymphoma | Phase 1 Phase 2 | Completed | - | Italy ... more >> Istituto Nazionale per la Cura e lo Studio dei Tumori Milano, Italy, 20133 Collapse << |
NCT00496431 | Hodgkin's Lymphoma | Phase 1 Phase 2 | Terminated(ITF2357 (Givinostat... more >>) was well tollerated but had limited activity against refractory/relapsed HL) Collapse << | - | Italy ... more >> Istituto Nazionale per lo studio e la cura dei Tumori Milan, Italy, 20133 Collapse << |
NCT00606307 | Myeloproliferative Diseases | Phase 2 | Completed | - | Italy ... more >> Ospedali riuniti Bergamo, Italy, 24158 IRCCS - Pol. San Matteo Pavia, Italy, 27100 Collapse << |
实验方案
技术信息
CAS号 | 497833-27-9 | 储存条件 |
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分子式 | C24H27N3O4 | 运输 | 蓝冰 | |
分子量 | 421.49 | 别名 | ITF-2357;gavinostat |
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
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NCT00792467 | Hodgkin's Lymphoma | Phase 1 Phase 2 | Completed | - | Italy ... more >> Istituto Nazionale per la Cura e lo Studio dei Tumori Milano, Italy, 20133 Collapse << |
NCT00496431 | Hodgkin's Lymphoma | Phase 1 Phase 2 | Terminated(ITF2357 (Givinostat... more >>) was well tollerated but had limited activity against refractory/relapsed HL) Collapse << | - | Italy ... more >> Istituto Nazionale per lo studio e la cura dei Tumori Milan, Italy, 20133 Collapse << |
NCT00606307 | Myeloproliferative Diseases | Phase 2 | Completed | - | Italy ... more >> Ospedali riuniti Bergamo, Italy, 24158 IRCCS - Pol. San Matteo Pavia, Italy, 27100 Collapse << |
NCT00792831 | Chronic Lymphocytic Leukemia | Phase 2 | Terminated(protocol needs comp... more >>lete restructuring in order to make it feasible and to complete the enrollment of 23 patients) Collapse << | - | Italy ... more >> Department of Internal Medicine and Public Health, University of Perugia Perugia, Italy, 06074 Collapse << |
NCT00570661 | Active Systemic ... more >> Onset Juvenile Idiopathic Arthritis Collapse << | Phase 2 | Completed | - | Serbia ... more >> Inst. of Rheumatology Belgrade Belgrade, Serbia, 11000 Collapse << |
NCT00442182 | Autoinflammatory Syndromes ... more >> HIDS TRAPS Schnitzler's Syndrome Collapse << | Phase 2 | Unknown | - | Netherlands ... more >> Radboud University Medical Centre Nijmegen Recruiting Nijmegen, Netherlands, 6500 HB Sub-Investigator: Evelien J Bodar, MD Collapse << |
NCT00792740 | Crohn's Disease | Phase 1 Phase 2 | Terminated(As no safety warnin... more >>gs were detected,Interim analysis from the first 40 patients reccomends to stop the trial for futility) Collapse << | - | Belgium ... more >> University Hospital Gasthuisber Leuven, Belgium, 3000 Collapse << |
NCT00792506 | Multiple Myeloma | Phase 2 | Terminated | - | Italy ... more >> Presidio Ospedaliero R. Binaghi Cagliari, Italy, 09127 Collapse << |
NCT01557452 | Juvenile Idiopathic Arthritis | Not Applicable | Terminated(Previous study DSC/... more >>08/2357/36 did not show efficacy for Givinostat in JIA. Decision wasn't related to any tolerability concerns) Collapse << | - | Czech Republic ... more >> 1st Faculty of Medicine and General Faculty Hospital Praha, Czech Republic, 12109 Collapse << |
NCT01261624 | Polyarticular Course Juvenile ... more >>Idiopathic Arthritis Collapse << | Phase 2 | Terminated(The primary reason ... more >>for the decision to discontinue the study is lack of enrolment; this decision is not related to any tolerability concerns with Givinostat) Collapse << | - | Belgium ... more >> Universitair Ziekenhuis Gent Gent, Belgium, 9000 Czech Republic 1st Faculty of Medicine and General Faculty Hospital Praha 2, Praha, Czech Republic, 12109 Italy Ospedale Meyer Firenze, FI, Italy, 50139 Policlinico G. Martino Messina, ME, Italy, 98125 Istituto Gaetano Pini Milano, MI, Italy, 20122 Azienda Ospedaliera-Università di Padova Padova, PD, Italy, 35128 Romania Institutul pentru Ocrotirea Mamei si Copilului "Alfred Rusescu" Bucarest, Romania, 020395 Spitalul Clinic de Urgenta pentru Copii "M.S. Curie" Bucarest, Romania, 041451 Serbia Mother and Child Health Institute "Dr Vukan Cupic" Novi Beograd, Belgrade, Serbia, 11070 Institute of Rheumatology Belgrade Belgrade, Serbia, 11000 University Clinical Center Nis Nis, Serbia, 18000 Slovenia Children's Hospital - University Medical Centre Ljubljana Ljubljana, Slovenia, SI-1000 Spain Hospital Ramón y Cajal Madrid, Spain, 28034 Collapse << |
NCT02851797 | Duchenne Muscular Dystrophy | Phase 3 | Recruiting | June 2020 | - |
NCT00928707 | Polycythemia Vera | Phase 2 | Completed | - | Italy ... more >> Azienda Ospedaliero-Universitaria Policlinico Consorziale di Bari Bari, BA, Italy, 70124 Azienda Ospedaliera Santa Croce e Carle di Cuneo Cuneo, CN, Italy, 12100 Azienda Ospedaliera di Rilievo Nazionale e di Alta Specializzazione Garibaldi di Catania Catania, CT, Italy, 95126 Fondazione I. R. C. C. S. - Casa sollievo della sofferenza di San Giovanni Rotondo San Giovanni Rotondo, FG, Italy, 71013 Azienda Ospedaliero-Universitaria Careggi di Firenze Florence, FI, Italy, 50134 Azienda Ospedaliera San Gerardo di Monza Monza, MB, Italy, 20052 Azienda Ospedaliera Universitaria Policlinico "Gaetano Martino" di Messina Messina, ME, Italy, 98125 Azienda Ospedaliera Ospedali Riuniti "Villa Sofia - Cervello" di Palermo Palermo, PA, Italy, 90146 Azienda Unità Sanitaria Locale di Pescara, Presidio Ospedaliero "Spirito Santo" Pescara, PE, Italy, 65124 Azienda Ospedaliera Santa Maria della Misericordia di Perugia Perugia, PG, Italy, 06156 Azienda Ospedaliera Universitaria Pisana Pisa, PI, Italy, 56126 Azienda Ospedaliera Ospedale San Carlo di Potenza Potenza, PT, Italy, 85100 Fondazione I.R.C.C.S.-Policlinico San Matteo, Pavia Pavia, PV, Italy, 27100 Azienda Ospedaliera "Bianchi-Melacrino-Morelli" Reggio di Calabria, RC, Italy, 891225 Azienda Ospedaliera Universitaria S. Luigi Gonzaga di Orbassano Orbassano, TO, Italy, 10043 Azienda Ospedaliero-Universitaria San Giovanni Battista("Le Molinette") di Torino Torino, TO, Italy, 10126 Ospedale Mauriziano Umberto I Torino, TO, Italy, 10128 Ospedale San Bortolo di Vicenza Vicenza, VI, Italy, 36100 Azienda Ospedaliera Ospedali Riuniti di Bergamo Bergamo, Italy, 24100 Azienda Ospedaliera Universitaria Università degli Studi di Napoli Federico II Napoli, Italy, 80131 Università "Campus Bio-Medico", Rome Rome, Italy, 00128 Policlinico Universitario Agostino Gemelli di Roma Rome, Italy, 00168 Collapse << |
NCT03373968 | Duchenne Muscular Dystrophy | Phase 2 Phase 3 | Recruiting | December 2023 | Italy ... more >> A.O.U. Policlinico G. Martino, U.O.C. Neurologia e Malattie Neuromuscolari Recruiting Messina, Italy, 98125 Contact: Giuseppe Vita, MD Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico di Milano, UOS di Neurologia Pediatrica Recruiting Milan, Italy, 20122 Contact: Giacomo Comi, MD Ospedale Pediatrico Bambino Gesù, Malattie Neuromuscolari e Neurodegenerative Recruiting Roma, Italy, 00146 Contact: Enrico Bertini, MD Fondazione Policlinico Universitario "A.Gemelli", UOC Neuropsichiatria Infantile Recruiting Roma, Italy, 00168 Contact: Eugenio Mercuri, MD Collapse << |
NCT01901432 | Polycythemia Vera | Phase 1 Phase 2 | Completed | - | France ... more >> CHU Amiens - Hôpital Sud Amiens Cedex 1, France, 80054 Hôpital Morvan - CHRU de Brest Brest Cedex, France, 29609 Hopital Saint Vincent de Paul - GHICL Lille Lille cedex, France, 59020 Hôpital Saint-Louis (AP-HP), Centre Investigations Cliniques Paris Cedex 10, France, 75475 Germany Charite Research Organisation GmbH Berlin, Germany, 10117 Universitaetsklinikum Carl Gustav Carus TU Dresden Dresden, Germany, 01307 Universitaetsklinikum Freiburg Freiburg, Germany, 79106 Universitaetsklinikum Koeln Koeln, Germany, 50937 Italy Azienda ospedaliero universitaria Consorziale Policlinico di Bari Bari, BA, Italy, 70124 Azienda Ospedaliera Papa Giovanni XXIII Bergamo, BG, Italy, 24127 Azienda Ospedaliero-Universitaria Careggi, Florence Florence, FI, Italy, 50134 Fondazione IRCCS Policlinico San Matteo Pavia, PV, Italy, 27100 Istituto Tumori Giovanni Paolo II - IRCCS Ospedale Oncologico di Bari Bari, Italy, 70124 Fondazione IRCCS Cà Granda, Ospedale Maggiore Policlinico Milano, Italy Università degli Studi di Napoli Federico II, Facoltà di Medicina e Chirurgia Napoli, Italy, 80131 Ospedale Civile dello Spirito Santo Pescara, Italy Azienda Ospedaliero Universitaria Pisana Pisa, Italy, 56126 Azienda Ospedaliera "Bianchi-Melacrino-Morelli" Reggio Calabria, Italy, 89125 Università Campus Bio-Medico di Roma Rome, Italy Ospedale San Bortolo di Vicenza Vicenza, Italy, 36100 Poland SP ZOZ Zespol Szpitali Miejskich w Chorzowie Chorzow, Poland, 41-500 Uniwersyteckie Centrum Kliniczne Gdansk, Poland, 80-952 United Kingdom Belfast City Hospital Belfast, United Kingdom, BT9 7BL Royal London Hospital London, United Kingdom, E1 1BB Royal Cornwall Hospital Truro, United Kingdom, TR1 3LJ Collapse << |
NCT01261624 | - | - | Terminated(The primary reason ... more >>for the decision to discontinue the study is lack of enrolment; this decision is not related to any tolerability concerns with Givinostat) Collapse << | - | - |
NCT01761968 | Chronic Myeloproliferative Neo... more >>plasms Collapse << | Phase 2 | Recruiting | December 2020 | France ... more >> Hopital Saint Vincent de Paul - GHICL Lille Recruiting Lille, Lille Cedex, France, 59020 Contact: Laurent Pascal, MD +33320874532 pascal.laurent@ghicl.net Principal Investigator: Laurent Pascal, MD Germany Charite Research Organization GmbH Recruiting Berlin, Germany, 10117 Contact: Antonio Pezzutto, Prof. antonio.pezzutto@charite.de Principal Investigator: Antonio Pezzutto, Prof. Universitaetsklinikum Freiburg, Innere Medizin I - Haematologie und Onkologie Recruiting Freiburg, Germany, 79106 Contact: Nikolas von Bubnoff, MD nikolas.bubnoff@uniklinik-freiburg.de Principal Investigator: Nikolas von Bubnoff, MD Italy Azienda Ospedaliero-Universitaria Policlinico Consorziale, Bari Recruiting Bari, BA, Italy, 70124 Contact: Giorgina Specchia, MD Principal Investigator: Giorgina Specchia, MD Istituto Tumori Giovanni Paolo II IRCCS Ospedale Oncologico di Bari Recruiting Bari, BA, Italy, 70125 Contact: Attilio Guarini, MD attilioguarini@oncologico.bari.it Azienda Ospedaliera Papa Giovanni XXIII Recruiting Bergamo, BG, Italy, 24127 Contact: Alessandro Rambaldi, MD arambaldi@hpg23.it Principal Investigator: Alessandro Rambaldi, MD Azienda Ospedaliero-Universitaria Careggi, Florence Recruiting Florence, FI, Italy, 50134 Contact: Alessandro M Vannucchi, MD Principal Investigator: Alessandro M Vannucchi, MD Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico UOS Oncoematologia anziano Recruiting Milan, MI, Italy, 20122 Contact: Alessandra Iurlo, Prof aiurlo@policlinico.mi.it Azienda Unità Sanitaria Locale - Presidio Ospedaliero "Spirito Santo", Pescara Recruiting Pescara, PE, Italy, 65124 Contact: Paolo Di Bartolomeo, MD Principal Investigator: Paolo Di Bartolomeo, MD Fondazione I.R.C.C.S.-Policlinico San Matteo, Pavia Recruiting Pavia, PV, Italy, 27100 Contact: Vittorio Rosti, MD Principal Investigator: Vittorio Rosti, MD Azienda Ospedaliera "Bianchi-Melacrino-Morelli" Recruiting Reggio Calabria, RC, Italy, 89125 Contact: Bruno Martino, MD Principal Investigator: Bruno Martino, MD Ospedale San Bortolo, Vicenza Recruiting Vicenza, VI, Italy, 36100 Contact: Marco Ruggeri, MD Principal Investigator: Marco Ruggeri, MD Azienda Ospedaliera Universitaria Università degli Studi "Federico II", Naple Recruiting Naples, Italy, 80131 Contact: Vincenzo Martinelli, MD Principal Investigator: Vincenzo Martinelli, MD Università "Campus Bio-Medico", Rome Recruiting Rome, Italy, 00128 Contact: Giuseppe Avvisati, MD Principal Investigator: Giuseppe Avvisati, MD United Kingdom Belfast City Hospital Recruiting Belfast, United Kingdom, BT9 7BL Contact: Mary Frances McMullin, MD m.mcmullin@qub.ac.uk Principal Investigator: Mary Frances McMullin, MD Royal Cornwall Hospital Recruiting Truro, United Kingdom, TR1 3LJ Contact: Richard Noble, MD richard.noble@rcht.cornwall.nhs.uk Principal Investigator: Richard Noble, MD Collapse << |
NCT03238235 | Becker Muscular Dystrophy | Phase 2 | Recruiting | May 2019 | Italy ... more >> Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico di Milano, UOS Recruiting Milan, Italy, 20122 Contact: Giacomo Comi, MD + 39 6443 ext 2524 giacomo.comi@unimi.it Collapse << |
NCT01761292 | Duchenne Muscular Dystrophy (D... more >>MD) Collapse << | Phase 1 Phase 2 | Completed | - | Italy ... more >> Azienda Ospedaliera Universitaria Policlinico G. Martino Messina, Italy, 98125 IRCCS Ca' Granda Ospedale Maggiore Policlinico di Milano Milano, Italy, 20122 Policlinico Agostino Gemelli Roma, Italy, 00168 Ospedale Pediatrico Bambino Gesù Rome, Italy, 00165 Collapse << |
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