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CAS No.: 732302-99-7

Givinostat HCl monohydrate Catalog No. CSN16577

Synonyms: ITF-2357 hydrochloride monohydrate;Givinostat HCl H2O;ITF-2357

ITF2357 HCl H2O is a potent HDAC inhibitor for Maize HD2, HD1-B and HD1-A with IC50 of 10 nM, 7.5 nM and 16 nM, respectively.

规格	价格	促销价格	库存	数量

400-920-2911

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tech@csnpharm.cn

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纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

靶点 HD1-A (Maize)

IC50:16nM HD1-B (Maize)

IC50:7.5nM HD2 (Maize)

IC50:10nM
描述In LPS-stimulated cultured human peripheral blood mononuclear cells (PBMCs), ITF2357(givinostat) reduces the release of TNFα, IL-1α, IL-1β, and IFNγ, with IC50 of 10-25 nM, respectively. Using the combination of IL-12 plus IL-18, ITF2357 reduces IFNγ and IL-6 production with IC50 of 12.5-25 nM, independent of decreased IL-1 or TNFα. ITF2357 is cytotoxic in multiple myeloma (MM) cell lines (RPMI8226, NCI-H929, JJN3, KMS 11, KMS 12, KMS 18, and KMS 20) and acute myelogenous leukemia (AML) cell lines (HL-60, THP-1, U937, KASUMI, KG-1, and TF-1), with IC50 of 200 nM. ITF2357 activates the intrinsic apoptotic pathway, upregulates p21 and downmodulates Bcl-2 and Mcl-1. ITF2357 inhibits the production of IL-6, VEGF, and IFNγ in mesenchymal stromal cells (MSCs) by 80-95%.
ITF2357 favors β-cell survival during inflammatory conditions. ITF2357 at concentrations of 25 and 250 nM increases islet cell viability, enhances insulin secretion, inhibits release of MIP-1α and MIP-2, reduces NO production and decreases apoptosis rates.
动物研究
剂量
Mice^[1] (p.o.): 0.1 mg/kg - 50 mg/kg

给药途径
p.o.

动物研究
剂量	Mice^[1] (p.o.): 0.1 mg/kg - 50 mg/kg
给药途径	p.o.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.1010 mL
- 10.5049 mL
- 21.0097 mL
- 5 mM
- 0.4202 mL
- 2.1010 mL
- 4.2019 mL
- 10 mM
- 0.2101 mL
- 1.0505 mL
- 2.1010 mL

技术信息

CAS号

732302-99-7

储存条件

粉末: Inert atmosphere,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C24H30ClN3O5

运输

蓝冰

分子量

475.97

别名

ITF-2357 hydrochloride monohydrate;Givinostat HCl H2O;ITF-2357;ITF2357 HCl;ITF2357 hydrochloride;Givinostat HCl;gavinostat;Givinostat HCl hydrate

溶解度

DMSO	255.0 mg/mL (535.8 mM)
Water	insoluble warming

动物实验配方

0.5% CMC-Na

12 mg/mL

suspension

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靶点	Description	IC50
HD1-A (Maize)		IC50:16nM
HD1-B (Maize)		IC50:7.5nM
HD2 (Maize)		IC50:10nM

Givinostat HCl monohydrate Catalog No. CSN16577

靶点选择性

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