CAS No.: 10238-21-8
Glibenclamide/格列本脲 Catalog No. CSN10055
Synonyms: Glyburide;GlibenclamideGlibenclamide;Micronase
Glibenclamide is a sulfonylurea compound that modulates insulin production.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 细胞研究
- Cell Data
- 临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点 NCT00347100 Diabetes Mellitus, Type 2 Phase 4 Completed - China ... more >> Sanofi-Aventis Beijing, China Collapse << NCT01706211 Diabetes Mellitus Non Insulin ... more >>Dependent Oral Agent Therapy Collapse << Phase 3 Completed - Taiwan ... more >> National Taiwan University Hospital Taipei, Taiwan, 10002 Collapse << NCT00608179 Type 2 Diabetes Not Applicable Completed - - - 更多
- 参考文献
- [1] Nieland TJ, Chroni A, et al. Cross-inhibition of SR-BI- and ABCA1-mediated cholesterol transport by the small molecules BLT-4 and glyburide. J Lipid Res. 2004 Jul;45(7):1256-65.
- [2] Winquist RJ, Heaney LA, et al. Glyburide blocks the relaxation response to BRL 34915 (cromakalim), minoxidil sulfate and diazoxide in vascular smooth muscle. J Pharmacol Exp Ther. 1989 Jan;248(1):149-56.
- [3] Núñez M, Medina V, Cricco G, et al. Glibenclamide inhibits cell growth by inducing G0/G1 arrest in the human breast cancer cell line MDA-MB-231. BMC Pharmacol Toxicol. 2013;14:6. Published 2013 Jan 11
- [4] Sokolovska J, Isajevs S, Sugoka O, et al. Comparison of the effects of glibenclamide on metabolic parameters, GLUT1 expression, and liver injury in rats with severe and mild streptozotocin-induced diabetes mellitus. Medicina (Kaunas). 2012;48(10):532-543
- [5] Gangji AS, Cukierman T, Gerstein HC, Goldsmith CH, Clase CM. A systematic review and meta-analysis of hypoglycemia and cardiovascular events: a comparison of glyburide with other secretagogues and with insulin. Diabetes Care. 2007;30(2):389-394
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 10238-21-8 | 储存条件 |
|
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| 分子式 | C23H28ClN3O5S | 运输 | 蓝冰 | |||||||
| 分子量 | 494.00 | 别名 | Glyburide;GlibenclamideGlibenclamide;Micronase;Diabeta;HB-420;HB419;Maninil;Neogluconin;格列本脲 | |||||||
| 溶解度 |
|
动物实验配方 |
| Cell Lines | Concentration | Assay Type | Time | Activity Description | Data Sources |
|---|
| CHO cells | - | Function assay | - | Inhibition of human SUR1/Kir6.2 expressed in CHO cells, IC50=0.0043 μM | 11356099 |
| HEK293 cells | - | Function assay | - | Inhibition of OATP1B1 (unknown origin) expressed in HEK293 cells using estradiol-17beta-glucuronide substrate, IC50=1.4 μM | 22587986 |
| INS-1E cells | - | Function assay | 1 h | Stimulation of insulin secretion in rat INS-1E cells after 1 hr by alphaLISA assay in presence of 5 mM glucose, EC50=0.003 μM | 24484900 |
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
|---|
| NCT00347100 | Diabetes Mellitus, Type 2 | Phase 4 | Completed | - | China ... more >> Sanofi-Aventis Beijing, China Collapse << |
| NCT01706211 | Diabetes Mellitus Non Insulin ... more >>Dependent Oral Agent Therapy Collapse << | Phase 3 | Completed | - | Taiwan ... more >> National Taiwan University Hospital Taipei, Taiwan, 10002 Collapse << |
| NCT00608179 | Type 2 Diabetes | Not Applicable | Completed | - | - |
| NCT02607410 | Type 2 Diabetes Mellitus | Phase 4 | Completed | - | Brazil ... more >> University of Sao Paulo General Hospital Sao Paulo, Brazil, 05403-000 Collapse << |
| NCT02133118 | - | - | Completed | - | Netherlands ... more >> Isala Zwolle, Overijssel, Netherlands, 8000 AB Collapse << |
| NCT00379769 | Diabetes Mellitus, Type 2 | Phase 3 | Completed | - | - |
| NCT00379769 | - | - | Completed | - | - |
| NCT00549874 | Type 2 Diabetes | Not Applicable | Completed | - | United States, Michigan ... more >> University of Michigan Ann Arbor, Michigan, United States, 48109 United States, Ohio University of Toledo - Health Campus Toledo, Ohio, United States, 43606 Collapse << |
| NCT01242215 | Type 2 Diabetes Mellitus | Phase 3 | Completed | - | Japan ... more >> Chubu, Japan Chugoku, Japan Hokkaido, Japan Kansai, Japan Kantou, Japan Kyushu, Japan Touhoku, Japan Collapse << |
| NCT01195259 | - | - | Completed | - | - |
| NCT01319734 | Type 2 Diabetes Mellitus | Phase 1 | Unknown | - | Sudan ... more >> Jaber abo aliz Recruiting Khartoum, Sudan, 1111 Contact: Khaled H Bakheet, MD,PhD +249912957764 khalid2_3456@yahoo.com Principal Investigator: Hamdan Z Hamdan, MBBS,MSc Collapse << |
| NCT00251940 | Type 2 Diabetes | Phase 3 | Terminated(The development pro... more >>gram has been terminated) Collapse << | - | - |
| NCT00286468 | Diabetes Mellitus | Phase 3 | Completed | - | - |
| NCT03029702 | Gestational Diabetes ... more >> Diabetes, Gestational Pregnancy in Diabetes Collapse << | Phase 4 | Recruiting | March 30, 2021 | United States, Pennsylvania ... more >> Magee Womens Hospital of UPMC Recruiting Pittsburgh, Pennsylvania, United States, 15213 Contact: Maisa Feghali, MD 412-641-4874 feghalim@upmc.edu Principal Investigator: Maisa Feghali, MD Collapse << |
| NCT01107717 | Diabetes | Not Applicable | Recruiting | December 2024 | United States, Texas ... more >> Texas Diabetes Institute Recruiting San Antonio, Texas, United States, 78229-3900 Contact: Muhammad Abdul-Ghani, MD, PhD 210-567-2391 ABDULGHANI@UTHSCSA.EDU Contact: Curtiss Puckett, PA (210) 358 7200 Curtiss.Puckett@uhs-sa.com Principal Investigator: Ralph DeFronzo, MD Collapse << |
| NCT01028846 | Type 2 Diabetes | Phase 2 | Recruiting | December 2022 | United States, New York ... more >> Albert Einstein College of Medicine of Yeshiva University Recruiting Bronx, New York, United States, 10461 Principal Investigator: Meredith Hawkins, MD Collapse << |
| NCT00232583 | Type 2 Diabetes Mellitus | Not Applicable | Completed | - | United States, Texas ... more >> University of Texas Southwestern Dallas, Texas, United States, 75390 Collapse << |
| NCT00232583 | - | - | Completed | - | - |
| NCT01934816 | Healthy Subjects | Not Applicable | Terminated(Technical Issues wi... more >>th intervention) Collapse << | - | United Kingdom ... more >> Royal Devon and Exeter NHS Foundation Trust Exeter, United Kingdom, EX25DW Collapse << |
| NCT00472875 | Type 1 Diabetes Mellitus | Phase 4 | Unknown | - | United Kingdom ... more >> King's College Hospital NHS Foundation Trust Recruiting London, United Kingdom, SE5 9RS Sub-Investigator: David Hopkins, MBBS FRCP Collapse << |
| NCT00371306 | Gestational Diabetes ... more >> Type 2 Diabetes Pregnancy Collapse << | Not Applicable | Unknown | September 2008 | United States, Tennessee ... more >> Regional Obstetrical Consultants Recruiting Chattanooga, Tennessee, United States, 37403 Collapse << |
| NCT00162175 | Metabolics Diabetes Nos | Phase 3 | Completed | - | - |
| NCT00286468 | - | - | Completed | - | - |
| NCT00313313 | Diabetes | Phase 3 | Completed | - | - |
| NCT00300105 | Type 2 Diabetes | Phase 3 | Terminated(The development pro... more >>gram has been terminated) Collapse << | - | - |
| NCT00035542 | Diabetes Mellitus, Non-Insulin... more >>-Dependent Collapse << | Phase 3 | Completed | - | - |
| NCT00700856 | Type 2 Diabetes Mellitus ... more >> Cardiovascular Disease Collapse << | Phase 4 | Unknown | December 2018 | - |
| NCT02624830 | Permanent Neonatal Diabetes Me... more >>llitus Collapse << | Phase 4 | Unknown | February 2016 | Norway ... more >> Haukeland University Hospital Bergen, Norway, 5021 Collapse << |
| NCT01698931 | Diabetes Diab... more >>etes Mellitus, Type 2 Collapse << | Phase 4 | Completed | - | Italy ... more >> Novo Nordisk Investigational Site Padova, Italy, 35137 Collapse << |
| NCT02624817 | Permanent Neonatal Diabetes Me... more >>llitus Collapse << | Phase 4 | Completed | - | Norway ... more >> Haukeland University Hospital Bergen, Norway, 5021 Collapse << |
| NCT01029795 | Diabetes Mellitus, Type 2 | Phase 2 | Terminated(Terminated due to n... more >>onclinical safety findings) Collapse << | - | Australia, South Australia ... more >> For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Elizabeth Vale, South Australia, Australia, 5112 Australia, Victoria For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. East Ringwood, Victoria, Australia, 3135 For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Heidelberg, Victoria, Australia, 3081 Austria For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Vienna, Austria, 1090 Czech Republic For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Holesov, Czech Republic, 769 01 For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Prague, Czech Republic, 140 59 Germany For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Mainz, Germany, 55116 For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Neuss, Germany, D-41460 Israel For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Jerusalem, Israel, 91120 For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Nahariya, Israel, 22100 Russian Federation For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Rostov-On-Don, Russian Federation, 344022 For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Saint Petersburg, Russian Federation, 191126 Spain For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Barcelona, Spain, 08022 For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Cordoba, Spain, 14004 For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Dos Hermanas, Spain, 41014 For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Teruel, Spain, 44002 Collapse << |
| NCT01029795 | - | - | Terminated(Terminated due to n... more >>onclinical safety findings) Collapse << | - | - |
| NCT03527537 | Gestational Diabetes | Phase 4 | Not yet recruiting | June 1, 2028 | United States, Wisconsin ... more >> Medical College of Wisconsin Not yet recruiting Milwaukee, Wisconsin, United States, 53226 Collapse << |
| NCT00696982 | Diabetes Mellitus ... more >> Arterial Stiffness Collapse << | Not Applicable | Unknown | June 2009 | Israel ... more >> Department of Internal Medicine A , Research & Development unit Assaf Harofeh Medical Center, Zerifin, affiliated to Sackler School of Medicine, Tel Aviv, Israel Recruiting Zrifin, Israel, 70300 Contact: Shlomit Koren, MD 972-546-888=385 shlomitks@gmail.com Contact: Shai Efrati, MD 972-577-346-364 efratishai@013.net Principal Investigator: Shlomit Koren, MD Collapse << |
| NCT00393718 | - | - | Completed | - | - |
| NCT01242137 | - | - | Unknown | - | Israel ... more >> Assaf Harofe Medical Center Recruiting Beer Yakov, Israel Contact: Amit Tirosh, Dr 972-52-4748989 tiroshamit@gmail.com Principal Investigator: Amit Tirosh, Dr Collapse << |
| NCT00035568 | Diabetes Mellitus, Non-Insulin... more >>-Dependent Collapse << | Phase 4 | Completed | - | United States, Arkansas ... more >> Local Institution Little Rock, Arkansas, United States United States, California Local Institution Los Angeles, California, United States United States, Illinois Local Institution Chicago, Illinois, United States United States, Indiana Local Institution Indianapolis, Indiana, United States United States, New York Local Institution Brooklyn, New York, United States Local Institution Rochester, New York, United States United States, Pennsylvania Local Institution Pittsburgh, Pennsylvania, United States United States, Texas Local Institution Dallas, Texas, United States Local Institution San Antonio, Texas, United States Collapse << |
| NCT01605773 | Diabetes Diab... more >>etes Mellitus, Type 2 Collapse << | Phase 4 | Completed | - | United States, Texas ... more >> Novo Nordisk Investigational Site Houston, Texas, United States, 77030 Collapse << |
| NCT00313313 | - | - | Completed | - | - |
| NCT00194896 | Type 2 Diabetes Mellitus | Not Applicable | Completed | - | United States, Washington ... more >> DVA Puget Sound Health Care System Seattle, Washington, United States, 98108 Collapse << |
| NCT00194896 | - | - | Completed | - | - |
| NCT00935363 | Healthy | Phase 1 | Withdrawn | April 2010 | - |
| NCT00333723 | Diabetes Mellitus, Type 2 | Phase 4 | Completed | - | - |
| NCT00393718 | Diabetes Diab... more >>etes Mellitus, Type 2 Collapse << | Phase 3 | Completed | - | Japan ... more >> Novo Nordisk Investigational Site Tokyo, Japan, 1000005 Collapse << |
| NCT01145534 | Diabetes | Phase 1 Phase 2 | Completed | - | Brazil ... more >> Centro de Especialidades Odontologicas Patos, Paraiba, Brazil, 58700-020 Collapse << |
| NCT02255006 | Healthy | Not Applicable | Unknown | December 2014 | Korea, Republic of ... more >> Kyung Hee University Medical Center Recruiting Seoul, Korea, Republic of, 130-701 Contact: Weon Kim, Professor 82-2-958-8176 mylovekw@hanmail.net Collapse << |
| NCT00770835 | Diabetes Mellitus | Phase 4 | Completed | - | Italy ... more >> Padova, Italy Pisa, Italy Collapse << |
| NCT02091336 | Gestational Diabetes | Phase 4 | Unknown | December 2016 | Brazil ... more >> Hospital de Clínicas de Porto Alegre Recruiting Porto Alegre, RS, Brazil, 90035-903 Collapse << |
| NCT00541437 | - | - | Completed | - | Taiwan ... more >> National Taiwan university hospital Taipei, Taiwan Collapse << |
| NCT02128022 | Angina Pectoris | Phase 1 | Completed | - | United Kingdom ... more >> Papworth Hospital Cambridge, Cambridgeshire, United Kingdom, CB23 3RE Collapse << |
| NCT00238472 | Diabetes Mellitus, Type 2 | Phase 4 | Completed | - | - |
| NCT01563120 | Gestational Diabetes Mellitus | Phase 4 | Completed | - | Israel ... more >> Dep. OB/GYN, Emek Medical Center Afula, Israel Collapse << |
| NCT00123643 | - | - | Completed | - | - |
| NCT01215331 | Gestational Diabetes Mellitus | Phase 3 | Completed | - | Canada, Quebec ... more >> Centre de recherche clinique du CHUS Sherbrooke, Quebec, Canada, J1H 5N4 Collapse << |
| NCT00123643 | Type 2 Diabetes Mellitus | Phase 4 | Completed | - | United States, Minnesota ... more >> St. Paul Heart Clinic St. Paul, Minnesota, United States, 55102 Collapse << |
| NCT01132703 | Traumatic Brain Injury ... more >> Stroke Collapse << | Phase 1 | Completed | - | United States, Michigan ... more >> Jasper Clinic Kalamazoo, Michigan, United States, 49007 Collapse << |
| NCT00521742 | Diabetes Mellitus | Phase 3 | Completed | - | - |
| NCT00388986 | Diabetes Mellitus Type 2 | Phase 1 | Completed | - | United States, California ... more >> Cypress, California, United States, 90630 United States, Hawaii Honolulu, Hawaii, United States, 96813 United States, New York Buffalo, New York, United States, NY 14215 United States, Texas San Antonio, Texas, United States, 78229 Collapse << |
| NCT01998113 | - | - | Completed | - | Spain ... more >> Hospital de la Santa Creu i Sant Pau Barcelona, Spain, 08025 Collapse << |
| NCT01947699 | Gestational Diabetes | Phase 4 | Withdrawn(PI decided to withdr... more >>awal study before recruitment started) Collapse << | - | United States, Pennsylvania ... more >> Magee Womens Hospital of UPMC Pittsburgh, Pennsylvania, United States, 15213 Collapse << |
| NCT02864953 | Brain Edema S... more >>troke, Acute Collapse << | Phase 3 | Recruiting | December 30, 2021 | - |
| NCT02201602 | Diabetes | Phase 4 | Completed | - | Singapore ... more >> Khoo Teck Puat Hospital Singapore, Singapore, 768828 Collapse << |
| NCT01329016 | Gestational Diabetes Mellitus | Phase 1 Phase 2 | Unknown | June 2015 | United States, Indiana ... more >> Indiana University School of Medicine Indianapolis, Indiana, United States, 46202 United States, Pennsylvania University of Pittsburgh Pittsburgh, Pennsylvania, United States, 15213 United States, Texas University of Texas Medical Branch Galveston, Texas, United States, 77555 United States, Washington University of Washington Seattle, Washington, United States, 98195 Collapse << |
| NCT00494312 | Diabetes Mellitus ... more >> Liver Collapse << | Phase 4 | Completed | - | - |
| NCT00521820 | Diabetes Mellitus | Phase 3 | Terminated(Higher incidence of... more >> hospitalization for congestive heart failure in pioglitazone-treated subjects compared to glyburide treated subjects.) Collapse << | - | - |
| NCT02375828 | Neonatal Diabetes Secondary to... more >> Mutation in the Potassium Channel Collapse << | Phase 3 | Completed | - | France ... more >> Hôpital Universitaire Necker Enfants Malades Paris, France, 7501 Collapse << |
| NCT00160485 | Gestational Diabetes | Phase 4 | Withdrawn(Active Duty principl... more >>e investigator currently deployed) Collapse << | June 2010 | United States, Hawaii ... more >> Tripler Army Medical Center Honolulu, Hawaii, United States, 97859 Collapse << |
| NCT00744965 | Mild Gestational Diabetes | Phase 4 | Completed | - | United States, Texas ... more >> Parkland Memorial Hospital Dallas, Texas, United States, 75235 Collapse << |
| NCT00836472 | Healthy | Phase 1 | Completed | - | Canada, Quebec ... more >> Anapharm Inc. Sainte-Foy, Quebec, Canada, GIV2K8 Collapse << |
| NCT00267683 | Diabetes Diab... more >>etes Mellitus, Type 2 Collapse << | Phase 3 | Terminated(This trial was term... more >>inated due to low recruitment) Collapse << | - | - |
| NCT01731431 | Diabetes Gest... more >>ational Collapse << | Phase 3 | Completed | - | France ... more >> Marie-Victoire Senat Paris, France, 94270 Collapse << |
| NCT03089333 | Hypertension ... more >>Diabetes Mellitus, Type 2 Blood Pressure Obesity Cardiac Hypertrophy Microalbuminuria Vascular Stiffness Collapse << | Phase 4 | Completed | - | Brazil ... more >> University of Campinas (UNICAMP) Campinas, São Paulo, Brazil, 13083970 Collapse << |
| NCT00835991 | - | - | Completed | - | - |
| NCT00759720 | Diabetes Mellitus | Phase 3 | Terminated(Potential hepatic s... more >>afety signal) Collapse << | - | - |
| NCT00610038 | Diabetes Mellitus | Phase 2 | Completed | - | France ... more >> Necker Hospital - Endocrinology Gynecology Pediatric unit Paris, France, 75015 Collapse << |
| NCT00965991 | Gestational Diabetes | Not Applicable | Completed | - | United States, New Mexico ... more >> University of New Mexico Diabetes in Pregnancy Clinic Albuquerque, New Mexico, United States, 87131 Collapse << |
| NCT00836472 | - | - | Completed | - | - |
| NCT00835991 | Healthy | Phase 1 | Completed | - | Canada, Quebec ... more >> Anapharm Inc. Sainte-Foy, Quebec, Canada, GIV2K8 Collapse << |
| NCT00865241 | Healthy | Phase 1 | Completed | - | United States, North Dakota ... more >> PRACS Institute, Ltd. Fargo, North Dakota, United States, 58102 Collapse << |
| NCT00865436 | Healthy | Phase 1 | Completed | - | United States, North Dakota ... more >> PRACS Institute, Ltd. Fargo, North Dakota, United States, 58102 Collapse << |
| NCT03078725 | Gestational Diabetes Mellitus,... more >> Class A2 Collapse << | Phase 4 | Withdrawn(Research was competi... more >>ng with other projects in the department, and no patients were recruited.) Collapse << | May 10, 2018 | - |
| NCT00451620 | Type 2 Diabetes | Phase 2 | Completed | - | Canada, British Columbia ... more >> University of British Columbia Vancouver, British Columbia, Canada Collapse << |
| NCT00255541 | Type 2 Diabetes | Phase 3 | Terminated(The development pro... more >>gram has been terminated) Collapse << | - | - |
| NCT00864734 | Healthy | Phase 1 | Completed | - | United States, North Dakota ... more >> PRACS Institute, Ltd. Fargo, North Dakota, United States, 58102 Collapse << |
| NCT00734669 | - | - | Completed | - | - |
| NCT02460874 | Cerebral Edema ... more >> Brain Metastases Collapse << | Phase 1 Phase 2 | Recruiting | October 2020 | United States, Alabama ... more >> University of Alabama at Birmingham (UAB) Department of Radiation Oncology Recruiting Birmingham, Alabama, United States, 35249 Contact: Kristin Webb kkwebb@uabmc.edu Contact: Valerie Powell vpowell@uabmc.edu Principal Investigator: Drexell H Boggs, MD Collapse << |
| NCT00279045 | Diabetes Mellitus, Type 2 | Phase 3 | Completed | - | - |
| NCT01268683 | Ischemic Stroke | Phase 1 Phase 2 | Completed | - | United States, Illinois ... more >> Rush University Medical Center Chicago, Illinois, United States, 60612 United States, Maryland University of Maryland Medical Center Baltimore, Maryland, United States United States, Massachusetts Massachusetts General Hospital Boston, Massachusetts, United States United States, Pennsylvania University of Pittsburgh Medical Center Pittsburgh, Pennsylvania, United States, 15213 Collapse << |
| NCT01268683 | - | - | Completed | - | - |
| NCT02080377 | Pregnancy Ges... more >>tational Diabetes Collapse << | Phase 3 | Completed | - | United Kingdom ... more >> Princess Royal Infirmary Glasgow, Lanarkshire, United Kingdom, G31 2ER Simpson Centre for Reproductive Health, Royal Infirmary Hospital, Edinburgh Edinburgh, Lothian, United Kingdom, EH16 4SA Western General Hospital Edinburgh, Lothian, United Kingdom, EH4 2XU St Johns Hospital Livingston, West Lothian, United Kingdom Queen Elizabeth Hospital Glasgow, United Kingdom Collapse << |
| NCT01794182 | Ischemic Stroke ... more >> Malignant Edema Collapse << | Phase 2 | Unknown | April 2016 | United States, Arizona ... more >> University of Arizona Medical Center Tucson, Arizona, United States, 85719 United States, California Stanford University Medical Center Stanford, California, United States, 94305 United States, Connecticut Yale University School of Medicine New Haven, Connecticut, United States, 06510 United States, Florida University of Florida, Jacksonville Jacksonville, Florida, United States, 32209 United States, Illinois Northwestern Memorial Hospital Chicago, Illinois, United States, 60611 United States, Kentucky University of Louisville Hospital Louisville, Kentucky, United States, 40202 United States, Maine Maine Medical Center Scarborough, Maine, United States, 04074 United States, Maryland University of Maryland School of Medicine Baltimore, Maryland, United States, 21201 United States, Massachusetts Massachusetts General Hospital Boston, Massachusetts, United States, 02114 UMASS Memorial Medical Center Worcester, Massachusetts, United States, 01655 United States, Ohio Cleveland Clinic Cleveland, Ohio, United States, 44195 Ohio State University Wexner Medical Center Columbus, Ohio, United States, 43210 United States, Oregon Oregon Health & Science University Hospital Portland, Oregon, United States, 97239 United States, Pennsylvania Abington Memorial Hospital Abington, Pennsylvania, United States, 19001 UPMC Presbyterian Hospital Pittsburgh, Pennsylvania, United States, 15213 United States, South Carolina Medical University of South Carolina Charleston, South Carolina, United States, 29425 United States, Utah University of Utah Healthcare Salt Lake City, Utah, United States, 84132 Collapse << |
| NCT01454154 | Traumatic Brain Injury | Phase 2 | Unknown | September 2015 | United States, California ... more >> University of California, San Diego San Diego, California, United States, 92103 United States, Maryland University of Maryland Medical Center, Shock Trauma Center Baltimore, Maryland, United States, 21201 United States, Pennsylvania UPMC Presbyterian Hospital Pittsburgh, Pennsylvania, United States, 15213 United States, Virginia VCU Medical Center Richmond, Virginia, United States, 23298 Collapse << |
| NCT00515801 | Diabetes Mellitus, Type 1 | Phase 2 Phase 3 | Completed | - | Switzerland ... more >> University Hospital Basel Basel, Switzerland, 4031 Collapse << |
| NCT02815787 | Type 2 Diabetes | Phase 1 | Completed | - | China, Shandong ... more >> Qilu Hospital of Shandong University Jinan, Shandong, China, 250012 Collapse << |
| NCT01716338 | Healthy Volunteers | Phase 1 | Completed | - | United States, Missouri ... more >> Washington University in St. Louis Clinical Research Unit (CRU) St. Louis, Missouri, United States, 63110 Collapse << |
| NCT02183428 | Healthy | Phase 1 | Completed | - | - |
| NCT01822548 | Type 2 Diabetes | Phase 3 | Completed | - | Italy ... more >> Azienda Opedaliera-Universitaria Parma, Italy, 43126 Azienda Ospedaliera-Universitaria Parma, Italy, 43126 Collapse << |
| NCT02919345 | Diabetes Mellitus, Type 2 ... more >> Coronary Artery Disease Carotid Artery Diseases Collapse << | Phase 4 | Unknown | October 2017 | Brazil ... more >> State University of Campinas Campinas, Sao Paulo, Brazil, 13083-887 Collapse << |
| NCT02318693 | Type 2 Diabetes Mellitus | Phase 4 | Completed | - | - |
| NCT01822548 | - | - | Completed | - | - |
| NCT01045590 | Diabetes Mellitus, Type 2 | Phase 4 | Completed | - | Korea, Republic of ... more >> GSK Investigational Site Seoul, Korea, Republic of, 110-744 GSK Investigational Site Seoul, Korea, Republic of, 120-752 GSK Investigational Site Seoul, Korea, Republic of, 135-710 GSK Investigational Site Seoul, Korea, Republic of, 137-701 Collapse << |
| NCT00417729 | Diabetes Mellitus | Phase 4 | Completed | - | Taiwan ... more >> Taichung Veterans General Hospital Taichung, Taiwan Collapse << |
| NCT01733108 | Healthy | Phase 1 | Completed | - | - |
| NCT01867502 | Diabetes Mellitus, Type 2 ... more >> Hypoglycemic Agents Diabetic Blood Glucose Monitoring Exercise Collapse << | Phase 4 | Unknown | August 2015 | Brazil ... more >> Hospital de Clínicas de Porto Alegre Porto Alegre Recruiting Porto Alegre, Rio Grande do Sul, Brazil, 90035-903 Contact: Aline Fofonka, MSc 55-5192339191 alinefofonka@hotmail.com Principal Investigator: Beatriz D Schaan, PhD Collapse << |
| NCT02726490 | Gestational Diabetes | Not Applicable | Terminated(Lack of Recruitment... more >>) Collapse << | - | United States, Texas ... more >> TTUHSC El Paso El Paso, Texas, United States, 79905 Collapse << |
| NCT03569540 | Subarachnoid Hemorrhage, Aneur... more >>ysmal Collapse << | Phase 4 | Recruiting | December 1, 2019 | Brazil ... more >> Hospital das Clínicas da Faculdade de Medicina de São Paulo Recruiting São Paulo, SP, Brazil, 05403000 Contact: Eberval Figueiredo, MD PHD +551126617152 ebgadelha@yahoo.com Principal Investigator: Bruno B Costa, MD Sub-Investigator: Isabella Windlin, MD Sub-Investigator: Nicollas R Nunes, MD Sub-Investigator: Vitor N Yamaki, MD Sub-Investigator: Edwin Koterba, MD, PHD Collapse << |
| NCT02318693 | - | - | Completed | - | - |
| NCT02524379 | Acute Spinal Cord Injury | Phase 1 Phase 2 | Recruiting | February 2020 | United States, Ohio ... more >> The Ohio State University Recruiting Columbus, Ohio, United States, 43210 Contact: Amy J Minnema 614-685-9827 amy.minnema@osumc.edu Principal Investigator: Francis Farhadi, MD, PhD Collapse << |
| NCT03741530 | Intracerebral Hemorrhage | Not Applicable | Enrolling by invitation | October 31, 2020 | China, Shaanxi ... more >> Xijing Hospital Xi'an, Shaanxi, China, 710032 Collapse << |
| NCT03284463 | Acute Stroke | Phase 4 | Recruiting | September 30, 2021 | China, Guangdong ... more >> Huadu District People's Hospital of Guangzhou Not yet recruiting Guangzhou, Guangdong, China, 510515 Contact: Xiangmin Liu, M.D. Nanfang Hospital of Southern Medical University Recruiting Guangzhou, Guangdong, China Contact: Kaibin Huang hkb@smu.edu.cn Principal Investigator: Suyue Pan, M.D., Ph.D. Heyuan People's Hospital Recruiting Heyuan, Guangdong, China Contact: Yunqiang Huang, M.D. +8613750225240 13750225240@126.com Maoming People's Hospital Recruiting Maoming, Guangdong, China Contact: Hao Li, M.D. 185416656@qq.com Principal Investigator: Zhi Yan, M.D. Maoming Traditional Chinese Medical Hospital Recruiting Maoming, Guangdong, China Contact: Dongrun Yan, M.D. 1792191@qq.com Principal Investigator: Wenguo Huang, M.D. China, Hainan Hainan Provincial Hospital of Traditional Chinese Medicine Recruiting Haikou, Hainan, China, 570100 Contact: Guangfeng Zhao, M.D. +8613700410380 408195770@qq.com Principal Investigator: Guohu Weng, M.D. China, Jiangsu The First Affiliated Hospital of Wenzhou Medical University Recruiting Wenzhou, Jiangsu, China, 325000 Contact: Saijun Zhou, M.D. +8613857746659 2498093074@qq.com Principal Investigator: Xu Zhang, M.D. Collapse << |
| NCT02830048 | Diabetes Mellitus, Type 2 | Phase 2 | Completed | - | United Kingdom ... more >> Clinical Research Unit, OCDEM, Churchill Hospital Oxford, Oxfordshire, United Kingdom, OX3 7LE Collapse << |
| NCT01456650 | Type 2 Diabetes | Phase 4 | Completed | - | Mexico ... more >> Instituto Nacional de Ciencias Medicas y Nutricion Mexico City, DF, Mexico, 14000 Collapse << |
| NCT02145611 | Type 2 Diabetes Mellitus ... more >> Hypertension Endothelial Dysfunction Collapse << | Phase 4 | Completed | - | Brazil ... more >> Fundação Faculdade Regional de Medicina de São José do Rio Preto São José do Rio Preto, São Paulo, Brazil, 15090-000 Collapse << |
| 靶点 | Description | IC50 |
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