|N-(环己基氨基甲酰基)-4-(2-(7-甲氧基-4,4-二甲基-1,3-二氧代-3,4-二氢异喹啉-2(1H)-基)乙基)苯磺酰胺|CsnPharm

CAS No.: 33342-05-1

Gliquidone/格列喹酮 Catalog No. CSN11102

Synonyms: AR-DF 26;Glurenorm;Beglynor

Gliquidone is an ATP-sensitive K+ channel antagonist with IC50 of 27.2 nM.

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描述Gliquidone, a sulfonylurea class drug used for treating diabetes mellitus type 2. Gliquidone reduced the body weight and the kidney weight/body weight ratio of mice. Gliquidone improved the kidney function, indicated by reductions in urinary protein, blood urea nitrogen, and serum creatinine and triglyceride. Gliquidone can ameliorate the diabetic symptoms of diabetic nephropathy through inhibiting Notch/Snail1 signaling pathway, improving anti-oxidative response and delaying renal interstitial fibrosis^[3]. Gliquidone treatment effectively reduced urinary protein in GK rats with diabetic nephropathy by improving glomerular lesions and promoting tubular reabsorption^[4]. Moreover, using gliquidone nanoparticles revealed ~2.5-fold increase in Cmax when taken orally in the form of hard gelatin capsules in comparison to free gliquidone. The developed strategy of gliquidone nanoparticles possess a keen potential for exhibiting anti-diabetic effect^[5].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT02476760	-	-	Completed	-	Canada, Quebec ... more >> Lady Davis Institute for Medical Research, Jewish General Hospital Montreal, Quebec, Canada, H3T1E2 Collapse <<
NCT02475499	-	-	Completed	-	Canada, Quebec ... more >> Lady Davis Institute for Medical Research, Jewish General Hospital Montreal, Quebec, Canada, H3T1E2 Collapse <<
NCT00568074	Diabetes Diab... more >>etes Mellitus, Type 2 Collapse <<	Phase 4	Completed	-	China, Shanghai ... more >> Novo Nordisk Investigational Site Shanghai, Shanghai, China, 200025 Novo Nordisk Investigational Site Shanghai, Shanghai, China, 200433 China, Sichuan Novo Nordisk Investigational Site Chengdu, Sichuan, China, 610041 China Novo Nordisk Investigational Site Beijing, China, 100029 Collapse <<

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参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.8953 mL
- 9.4763 mL
- 18.9526 mL
- 5 mM
- 0.3791 mL
- 1.8953 mL
- 3.7905 mL
- 10 mM
- 0.1895 mL
- 0.9476 mL
- 1.8953 mL

技术信息

CAS号

33342-05-1

储存条件

粉末: Inert atmosphere,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C27H33N3O6S

运输

蓝冰

分子量

527.63

别名

AR-DF 26;Glurenorm;Beglynor;Glikvidon;Glycvidon;Sanofi Synthelabo brand of gliquidone;Yamanouchi brand of gliquidone;格列喹酮

溶解度

DMSO	200.0 mg/mL (379.1 mM)
Water	insoluble

动物实验配方

2% DMSO+corn oil

5 mg/mL

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