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CAS No.: 942918-07-2
Synonyms: GSK-1070916A;NMI-900
GSK1070916 is a reversible and ATP-competitive inhibitor of Aurora B/C with IC50 of 3.5 nM/6.5 nM and displays > 100-fold selectivity against the closely related Aurora A-TPX2 complex (IC50=490 nM).
生物活性
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
---|---|---|---|---|---|
NCT01118611 | Unspecified Adult Solid Tumor,... more >> Protocol Specific Collapse << | Phase 1 | Completed | - | United Kingdom ... more >> Leeds Cancer Centre at St. James's University Hospital Leeds, England, United Kingdom, LS9 7TF Barts and the London School of Medicine London, England, United Kingdom, EC1M 6BQ Collapse << |
实验方案
技术信息
CAS号 | 942918-07-2 | 储存条件 |
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分子式 | C30H33N7O | 运输 | 蓝冰 | |
分子量 | 507.63 | 别名 | GSK-1070916A;NMI-900 |
Cell Lines | Concentration | Assay Type | Time | Activity Description | Data Sources |
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A549 cells | - | Proliferation assay | 6-7 d | Antiproliferative activity against human A549 cells after 6 to 7 days by celltiter-glo luminescence assay in absence of 70% human serum albumin, EC50=0.007 μM | 20420387 |
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
---|
NCT01118611 | Unspecified Adult Solid Tumor,... more >> Protocol Specific Collapse << | Phase 1 | Completed | - | United Kingdom ... more >> Leeds Cancer Centre at St. James's University Hospital Leeds, England, United Kingdom, LS9 7TF Barts and the London School of Medicine London, England, United Kingdom, EC1M 6BQ Collapse << |
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