CAS No.: 1325212-97-2
GSK-2245035 maleate Catalog No. CSN20419
GSK2245035 maleate is a selective Toll-like receptor 7 (TLR7) agonist with preferential Type-1 interferon (IFN)-stimulating properties which displays extraordinary IFNα inducing potency and IFNα/TNFα selectivity.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 参考文献
- [1] Biggadike K, Ahmed M, et al. Discovery of 6-Amino-2-{[(1S)-1-methylbutyl] oxy}-9-[5-(1-piperidinyl)pentyl] -7,9-dihydro-8H-purin-8-one (GSK2245035), a Highly Potent and Selective Intranasal Toll-Like Receptor 7 Agonist for the Treatment of Asthma. J Med Chem. 2016 Mar 10;59(5):1711-26.
- [2] Tsitoura D, Ambery C, et al. Early clinical evaluation of the intranasal TLR7 agonist GSK2245035: Use of translational biomarkers to guide dosing and confirm target engagement. Clin Pharmacol Ther. 2015 Oct;98(4):369-80.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 1325212-97-2 | 储存条件 |
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| 分子式 | C24H38N6O6 | 运输 | 蓝冰 | |
| 分子量 | 506.60 | 别名 |
