CAS No.: 720690-73-3
GSK189254A Catalog No. CSN18994
Synonyms: GSK189254;GSK-189254 free base
GSK189254A is a potent and selective histamine H3 receptor antagonist with pKi values of 9.59-9.90 and 8.51-9.17 for human and rat H3, respectively.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 参考文献
- [1] Guo RX, Anaclet C, et al. Differential effects of acute and repeat dosing with the H3 antagonist GSK189254 on the sleep-wake cycle and narcoleptic episodes in Ox-/- mice. Br J Pharmacol. 2009 May;157(1):104-17.
- [2] Medhurst AD, Atkins AR, et al. GSK189254, a novel H3 receptor antagonist that binds to histamine H3 receptors in Alzheimer's disease brain and improves cognitive performance in preclinical models. J Pharmacol Exp Ther. 2007 Jun;321(3):1032-45.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 720690-73-3 | 储存条件 |
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| 分子式 | C21H25N3O2 | 运输 | 蓝冰 | |
| 分子量 | 351.44 | 别名 | GSK189254;GSK-189254 free base |
