CAS No.: 1209500-46-8
GsMTx4/GsMTx4游离态 Catalog No. CSN34303
GsMTx4 is a spider venom peptide. It selectively inhibits cationic mechanosensitive channels (MSCs) such as TRPC1 and TRPC6 and Piezo channels.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 参考文献
- [1] Gnanasambandam R, et al. GsMTx4: Mechanism of Inhibiting Mechanosensitive Ion Channels. Biophys J. 2017 Jan 10;112(1):31-45.
- [2] Suchyna TM, Johnson JH, Hamer K, et al. Identification of a peptide toxin from Grammostola spatulata spider venom that blocks cation-selective stretch-activated channels [published correction appears in J Gen Physiol 2001 Apr;117(4):371]. J Gen Physiol. 2000;115(5):583-598.
- [3] Acheva A, Kärki T, Schaible N, Krishnan R, Tojkander S. Adipokine Leptin Co-operates With Mechanosensitive Ca2 +-Channels and Triggers Actomyosin-Mediated Motility of Breast Epithelial Cells. Front Cell Dev Biol. 2021;8:607038.
- [4] Velasco-Estevez M, Gadalla KKE, Liñan-Barba N, Cobb S, Dev KK, Sheridan GK. Inhibition of Piezo1 attenuates demyelination in the central nervous system. Glia. 2020;68(2):356-375.
- [5] Park SP, Kim BM, Koo JY, et al. A tarantula spider toxin, GsMTx4, reduces mechanical and neuropathic pain. Pain. 2008;137(1):208-217.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 1209500-46-8 | 储存条件 |
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| 分子式 | 运输 | 蓝冰 | ||
| 分子量 | N/A | 别名 |
