|(E)-3-(2,4-二甲氧基苯基)亚甲基)-3,4,5,6-四氢-2,3'-联吡啶二盐酸盐|CsnPharm

CAS No.: 156223-05-1

GTS-21 2HCl/GTS-21二盐酸盐（DMBX-A） Catalog No. CSN13182

Synonyms: DMXB-A;DMBX-anabaseine;GTS-21 (hydrochloride)

GTS-21 2HCl is a selective α7 nicotinic acetylcholine receptor agonist, has recently been established as a promising treatment for inflammation.

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技术信息

生物活性

描述The α7-nAChR is a ligand-gated ion channel and is expressed in pivotal brain regions (e.g., the cerebral cortex and hippocampus) responsible for cognitive functions^[3]. GTS-21 2HCl is a selective α7-nAChR agonist with anti inflammatory and cognition enhancing activities. It is also a α4β2 (K_i = 20 nM for human α4β2) and 5-HT3A receptor (IC₅₀ = 3.1 μM) antagonist which binds to human α4β2 nAChR 100-fold more potently than to human α7-nAChR^[4]. In vivo, GTS 21 (4 mg/kg; i.p.; 1, 3, 7, 14 and 21 days) reduced radiation-induced histological signs of pulmonary injury in C57BL6 mice^[5].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT00783068	Endotoxemia S... more >>epsis Vagal Activity Collapse <<	Not Applicable	Completed	-	Netherlands ... more >> Radboud University Nijmegen Medical Centre Nijmegen, GLD, Netherlands, 6525 GA Collapse <<

参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.6226 mL
- 13.1132 mL
- 26.2263 mL
- 5 mM
- 0.5245 mL
- 2.6226 mL
- 5.2453 mL
- 10 mM
- 0.2623 mL
- 1.3113 mL
- 2.6226 mL

技术信息

CAS号

156223-05-1

储存条件

粉末: Inert atmosphere,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C19H22Cl2N2O2

运输

蓝冰

分子量

381.30

别名

DMXB-A;DMBX-anabaseine;GTS-21 (hydrochloride);GTS-21 HCl;GTS-21 hydrochloride;GTS-21;DMBX-A

溶解度

DMSO	16.0 mg/mL (42.0 mM) warming
Water	50.0 mg/mL (131.1 mM) warming

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GTS-21 2HCl/GTS-21二盐酸盐（DMBX-A） Catalog No. CSN13182

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