CAS No.: 666260-75-9
GW842166X Catalog No. CSN19173
Synonyms: 842166X;842166;GW-842166
GW842166X is a potent and highly selective agonist of cannabinoid receptor CB2 receptor with EC50 of 63 nM, shows no significant activity at CB1 receptor.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点 NCT00444769 Pain Phase 2 Completed - Germany ... more >> GSK Investigational Site Hamburg, Germany, 22769 Italy GSK Investigational Site Verona, Veneto, Italy, 37134 United Kingdom GSK Investigational Site London, United Kingdom, WC1X 8LD Collapse << NCT00511524 Pain, Inflammatory Phase 1 Completed - Sweden ... more >> GSK Investigational Site Uppsala, Sweden, SE-753 23 Collapse << NCT00554762 Healthy Subjects Phase 1 Withdrawn(Compound terminated) March 2008 - - 更多
- 参考文献
- [1] Yao BB, Hsieh GC, et al. In vitro and in vivo characterization of A-796260: a selective cannabinoid CB2 receptor agonist exhibiting analgesic activity in rodent pain models. Br J Pharmacol. 2008 Jan;153(2):390-401.
- [2] Giblin GM, O'Shaughnessy CT, et al. Discovery of 2-[(2,4-dichlorophenyl)amino] -N-[(tetrahydro-2H-pyran-4-yl)methyl] -4-(trifluoromethyl)- 5-pyrimidinecarboxamide, a selective CB2 receptor agonist for the treatment of inflammatory pain. J Med Chem. 2007 May 31;50(11):2597-600.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 666260-75-9 | 储存条件 |
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| 分子式 | C18H17Cl2F3N4O2 | 运输 | 蓝冰 | |
| 分子量 | 449.25 | 别名 | 842166X;842166;GW-842166 |
