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您的位置 : 首页 / Natural Product / Others-NP / Gypenoside L/绞股蓝皂苷L

CAS No.: 94987-09-4

Gypenoside L/绞股蓝皂苷L Catalog No. CSN61138

Synonyms: 绞股蓝皂苷L

Gypenoside L

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靶点选择性

生物活性

描述Gypenoside L is a saponin isolated from Gynostemma pentaphyllum. It caused cell cycle arrest at S phase, reduced the expression of CDK2, CDK4, CDK6, and cyclin D1, activated senescence-related cell cycle inhibitor proteins (p21 and p27) and their upstream regulators, activated p38 and ERK MAPK pathways and NF-κB pathway to induce senescence^[1]. It also induced cell death, which was associated with lysosomal swelling and autophagic flux inhibition, increased the levels of ROS, triggered protein ubiquitination and ER stress response, leading to Ca2+ release from ER IP3R-operated stores and finally cell death^[2].
参考文献

[1] Liao C, Zheng K, Li Y, Xu H, Kang Q, Fan L, Hu X, Jin Z, Zeng Y, Kong X, Zhang J, Wu X, Wu H, Liu L, Xiao X, Wang Y, He Z. Gypenoside L inhibits autophagic flux and induces cell death in human esophageal cancer cells through endoplasm reticulum stress-mediated Ca2+ release. Oncotarget. 2016 Jul 26;7(30):47387-47402. doi: 10.18632/oncotarget.10159. PMID: 27329722; PMCID: PMC5216949.
[2] Zheng K, Liao C, Li Y, Fan X, Fan L, Xu H, Kang Q, Zeng Y, Wu X, Wu H, Liu L, Xiao X, Zhang J, Wang Y, He Z. Gypenoside L, Isolated from Gynostemma pentaphyllum, Induces Cytoplasmic Vacuolation Death in Hepatocellular Carcinoma Cells through Reactive-Oxygen-Species-Mediated Unfolded Protein Response. J Agric Food Chem. 2016 Mar 2;64(8):1702-11. doi: 10.1021/acs.jafc.5b05668. Epub 2016 Feb 22. PMID: 26870999.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.2484 mL
- 6.2421 mL
- 12.4842 mL
- 5 mM
- 0.2497 mL
- 1.2484 mL
- 2.4968 mL
- 10 mM
- 0.1248 mL
- 0.6242 mL
- 1.2484 mL

技术信息

CAS号	94987-09-4		储存条件	粉末 Sealed in dry,2-8°C 液体 -20°C:3-6 月 -80°C:12月
分子式	C42H72O14		运输	蓝冰
分子量	801.01		别名	绞股蓝皂苷L

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总药量计算器 ✕

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工作液计算器 ✕

动物实验：给药剂量mg/kg 动物体重g 给药体积μL

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