|L-鸟氨酸盐酸盐|CsnPharm

CAS No.: 3184-13-2

L-鸟氨酸盐酸盐 Catalog No. CSN23401

Synonyms: (S)-2;5-Diaminopentanoic acid;L-Ornithine HCl

H-Orn-OH HCl is required intermediate in arginine biosynthesis. It is found in virtually all vertebrate tissues.

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技术信息

生物活性

描述H-Orn-OH HCl is an arginase inhibitors. Only marginal effects of the arginase inhibitors were registered on the tension induced by NE and the relaxation exerted by EFS (electrical field stimulation). Arginase inhibitors appeared to be ineffective in reversing the adrenergic tension and increasing the electrically induced relaxation of isolated HCC (human corpus cavernosum)^[1]. Arg I and Arg II were expressed in the transition zone of the prostate. The tension induced by noradrenaline was antagonized by the drugs in the following rank order of efficacy: H-Orn-OH × HCl ≥ H-Ile-OH ≥ DFMO > nor-NOHA; however, the maximum reversion of tension recorded ranged from only -25 to -13%. The enhancement in cyclic GMP production registered in the presence of the arginase inhibitors ranged from four- to 14-fold. Isometric tension studies and measurement of cyclic GMP showed that inhibition of arginase can reverse, to a certain degree, the tension of human prostate tissue induced by the activation of α-adrenoceptors and enhance the accumulation of cyclic GMP^[2].
参考文献

[1] Lorenzen JM, Ückert S, Scheller F, Haller H, Kuczyk MA. Effects of arginase inhibitors on the contractile and relaxant responses of isolated human penile erectile tissue. World J Urol. 2009;27(6):805-810
[2] Kedia GT, Sonnenberg JE, Kuczyk MA, Uckert S. Arginase enzymes in the human prostate: expression of arginase isoenzymes and effects of arginase inhibitors on isolated human prostate tissue. BJU Int. 2012;110(11 Pt C):E1196-E1201

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 5.9304 mL
- 29.6521 mL
- 59.3043 mL
- 5 mM
- 1.1861 mL
- 5.9304 mL
- 11.8609 mL
- 10 mM
- 0.5930 mL
- 2.9652 mL
- 5.9304 mL

技术信息

CAS号

3184-13-2

储存条件

粉末: Keep in dark place,Inert atmosphere,Room temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C5H13ClN2O2

运输

蓝冰

分子量

168.62

别名

(S)-2;5-Diaminopentanoic acid;L-Ornithine HCl;L-Ornithine (hydrochloride);L-鸟氨酸盐酸盐

溶解度

DMSO

Insoluble

动物实验配方

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