CAS No.: 349085-38-7
HC-030031 Catalog No. CSN16823
Synonyms: TOSLAB 829227
HC-030031 is a blocker of TRPA1 channel that exhibits antagonistic effect on AITC- and formalin-evoked calcium influx with IC50 of 6.2 μM and 5.3 μM respectively.
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400-920-2911
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 细胞研究
- Cell Data
- 参考文献
- [1] Eid SR, Crown ED, et al. HC-030031, a TRPA1 selective antagonist, attenuates inflammatory- and neuropathy-induced mechanical hypersensitivity. Mol Pain. 2008 Oct 27;4:48.
- [2] McNamara CR, Mandel-Brehm J, et al. TRPA1 mediates formalin-induced pain. Proc Natl Acad Sci U S A. 2007 Aug 14;104(33):13525-30.
- [3] Eid SR, Crown ED, Moore EL, Liang HA, Choong KC, Dima S, Henze DA, Kane SA, Urban MO. HC-030031, a TRPA1 selective antagonist, attenuates inflammatory- and neuropathy-induced mechanical hypersensitivity. Mol Pain. 2008 Oct 27;4:48
- [4] Pereira LM, Lima-Júnior RC, Bem AX, Teixeira CG, Grassi LS, Medeiros RP, Marques-Neto RD, Callado RB, Aragão KS, Wong DV, Vale ML, Brito GA, Ribeiro RA. Blockade of TRPA1 with HC-030031 attenuates visceral nociception by a mechanism independent of inflammatory resident cells, nitric oxide and the opioid system. Eur J Pain. 2013 Feb;17(2):223-33
- [5] Gupta R, Saito S, Mori Y, Itoh SG, Okumura H, Tominaga M. Structural basis of TRPA1 inhibition by HC-030031 utilizing species-specific differences. Sci Rep. 2016 Nov 22;6:37460
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 349085-38-7 | 储存条件 |
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| 分子式 | C18H21N5O3 | 运输 | 蓝冰 | |||||||||||
| 分子量 | 355.39 | 别名 | TOSLAB 829227 | |||||||||||
| 溶解度 |
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动物实验配方 |
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