|HCGRP-(8-37) 三氟乙酸盐|CsnPharm

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Synonyms: HCGRP-(8-37) is a human calcitonin gene-related peptide (hCGRP) fragment and also an antagonist of CGRP receptor.

HCGRP-(8-37)

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400-920-2911

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400-920-2911

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描述HCGRP-(8-37) (TFA salt) is a human calcitonin gene-related peptide (hCGRP) fragment and also an antagonist of CGRP receptor. In rat liver plasma membrane, where CGRP receptors predominate and CT appears to act through these receptors, hCGRP-(8-37) dose dependently displaced 125I-[Tyr0]rat CGRP binding. However, hCGRP-(8-37) had no effect on adenylate cyclase activity in liver plasma membrane. Furthermore, hCGRP-(8-37) inhibited adenylate cyclase activation induced not only by hCGRP but also by hCT^[2]. The structure of the C-terminal segment of hCGRP 8-37 appears to be critical for antagonistic activity at CGRP1 receptors^[3]. Functional experiments confirmed that the N-terminally derivatized analogues of h-alpha-CGRP(8-37) are antagonists that are more potent than h-alpha-CGRP(8-37) ^[4]. Intrathecal injection of CGRP (8-37) in mice produced hypothermia which differed from that produced by CGRP in time course, duration of action and potency. The combination of CGRP and CGRP (8-37) resulted in a decrease in body temperature which was no greater than that of either drug alone. Dose-dependent antinociception was produced by CGRP (8-37) in the p-phenylquinone (PPQ) assay, with an ED50 value of 6.0 micrograms. However, CGRP (8-37) failed to block or enhance the antinociception produced by CGRP over a wide dose range^[5].
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CAS号	N/A	储存条件	粉末 Keep in dark place,Inert atmosphere,Store in freezer, under -20°C 液体 -20°C:3-6 月 -80°C:12月
分子式	C141H231F3N44O40	运输	蓝冰
分子量	3239.61	别名	HCGRP-(8-37) is a human calcitonin gene-related peptide (hCGRP) fragment and also an antagonist of CGRP receptor.

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