|海柯皂苷元|CsnPharm

CAS No.: 467-55-0

Hecogenin/海柯皂苷元 Catalog No. CSN19362

Synonyms: (+)-Hecogenin;NSC 115921;Hocogenin

Hecogenin is a natural product isolated and purified from the roots of Aconitum carmichaeli Debx with antioxidant and anti-inflammatory properties, which can protect gastro by K⁺(ATP) channels opening and the COX-2/PG pathway.

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生物活性

描述Hecogenin is a natural product isolated and purified from the roots of Aconitum carmichaeli Debx with antioxidant and anti-inflammatory properties, which can protect gastro by K⁺(ATP) channels opening and the COX-2/PG pathway. Hecogenin acetate attenuates mechanical hyperalgesia by blocking the neural transmission of pain at the spinal cord levels and by cytokines-inhibitory mechanisms. Hecogenin acetate also exerts anti-cancer effects by modulating reactive species production, inducing cell cycle arrest and senescence and also modulating ERK1/2 phosphorylation and MMP-2 production.
参考文献

[1] Kumar RN, Lee S. Synthesis of 23-deoxy-25-epi north unit of cephalostatin 1 via reductive and oxidative modifications of hecogenin acetate. Steroids. 2017 Feb;118:68-75.
[2] Ingawale DK, Patel SS. Anti-Inﬂammatory Potential of Hecogenin in Experimental Animals: Possible Involvement of Inflammatory Cytokines and Myeloperoxidase. Drug Res (Stuttg). 2016 Dec;66(12):644-656.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.3222 mL
- 11.6112 mL
- 23.2223 mL
- 5 mM
- 0.4644 mL
- 2.3222 mL
- 4.6445 mL
- 10 mM
- 0.2322 mL
- 1.1611 mL
- 2.3222 mL

技术信息

CAS号	467-55-0	储存条件	粉末 Sealed in dry,Room Temperature 液体 -20°C:3-6 月 -80°C:12月
分子式	C27H42O4	运输	蓝冰
分子量	430.62	别名	(+)-Hecogenin;NSC 115921;Hocogenin

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