|(4aS,6aS,6bR,8aR,9R,10S,12aR,12bR,14bS)-(2S,3R,4S,5S,6R)-6-((((2R,3R,4R,5S,6R)-3,4-二羟基-6-(羟甲基)-5-(((2S,3R,4R,5R,6S)-3,4,5-三羟基-6-甲基四氢-2H-吡喃-2-基)氧基)四氢-2H-吡喃-2-基)氧基)甲基)-3,4,5-三羟基四氢-2H-吡喃-2-基 10-(((2S,3R,4S,5S)-4,5-二羟基-3 -(((2S,3R,4R,5R,6S)-3,4,5-三羟基-6-甲基四氢-2H-吡喃-2-基)氧基)四氢-2H-吡喃-2-基)氧基)- 9-(羟甲基)-2,2,6a,6b,9,12a-六甲基-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-二十氢苉-4a-羧酸酯|CsnPharm

CAS No.: 14216-03-6

Hederacoside C/常春藤苷C Catalog No. CSN11139

Synonyms: Kalopanaxsaponin B;Hederasaponin C;Glycoside L-H2

Hederacoside C is a naturally occuring saponin found in K. pictus with anti-inflammatory activity. It inhibited AChE with IC50 value of 31.3 μM.

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技术信息

生物活性

描述Hederacoside-C (HDC), a natural compound extracted from the leaves of Hedera helix with inflammation modulatory properties in variety of disorders. HDC pretreatment suppressed the advanced glycation end-products (AGEs) induced over-regulation of ROS level and inflammatory factors. Moreover, HDC also downregulate the degradation of ECM induced by AGEs. Mechanistically, the HDC suppressed NF-κB signaling pathway in chondrocyte^[3]. Moreover, HDC may have the potential to be an effective anti-inflammatory drug for the S. aureus-induced mice mastitis and in RAW 264.7 cells^[4]. HDC was administered intraperitoneally 1 h after infection until 24 h. The dose was repeated every 8 h for three successful doses. HDC significantly reduced the pulmonary edema, white blood cells, wet-dry ratio (W/D) and myeloperoxidase (MPO) activity^[5]. Intravenous administration of HDC results in relatively slow clearance (1.46-2.08 mL/min/kg) and a small volume of distribution at steady state (138-222 mL/kg), while oral administration results in a low absolute oral bioavailability (F) of 0.118-0.250%^[6].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 0.8187 mL
- 4.0937 mL
- 8.1875 mL
- 5 mM
- 0.1637 mL
- 0.8187 mL
- 1.6375 mL
- 10 mM
- 0.0819 mL
- 0.4094 mL
- 0.8187 mL

技术信息

CAS号

14216-03-6

储存条件

粉末: Inert atmosphere,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C59H96O26

运输

蓝冰

分子量

1221.38

别名

Kalopanaxsaponin B;Hederasaponin C;Glycoside L-H2;Hederoside H1;常春藤苷C

溶解度

DMSO	260.0 mg/mL (212.9 mM)
Water	220.0 mg/mL (180.1 mM)

动物实验配方

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