|N-羟基-N’-(4-丁基-2-甲基苯基)甲脒|CsnPharm

CAS No.: 339068-25-6

HET0016 Catalog No. CSN20292

Synonyms: N-hydroxy-N'-(4-n-butyl-2-methylphenyl)Formamidine

HET-0016 is a potent and selective inhibitor of the biosynthesis of 20-HETE in human renal microsomes with an IC50 of 8.9 nM, selectively inhibiting CYP4A and 4F isoforms.

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400-920-2911

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描述HET-0016 is a potent and selective inhibitor of the biosynthesis of 20-HETE in human renal microsomes with an IC50 of 8.9 nM, selectively inhibiting CYP4A and 4F isoforms. HET0016 inhibits CYP2C9, CYP2D6, and CYP3A4: enzymes that are important in drug metabolism, significantly less effectively with IC50s in the μM range. The IC50 values for inhibition of Cox (cyclooxygenase) and epoxyeicosatrienoic acids (EETs) formation are 2.3 and 2.8 μM, respectively. HET-0016 also inhibits cerebrovascular constriction induced by calcium or arachidonate and inhibits angiogenesis and endothelial cell sprouting in various models.
参考文献

[1] Jain M, Gamage NH, et al. Intravenous Formulation of HET0016 Decreased Human Glioblastoma Growth and Implicated Survival Benefit in Rat Xenograft Models. Sci Rep. 2017 Jan 31;7:41809.
[2] Borin TF, Zuccari DA, et al. HET0016, a selective inhibitor of 20-HETE synthesis, decreases pro-angiogenic factors and inhibits growth of triple negative breast cancer in mice. PLoS One. 2014 Dec 30;9(12):e116247.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 4.8477 mL
- 24.2384 mL
- 48.4768 mL
- 5 mM
- 0.9695 mL
- 4.8477 mL
- 9.6954 mL
- 10 mM
- 0.4848 mL
- 2.4238 mL
- 4.8477 mL

技术信息

CAS号	339068-25-6	储存条件	粉末 Inert atmosphere,Store in freezer, under -20°C 液体 -20°C:3-6 月 -80°C:12月
分子式	C12H18N2O	运输	蓝冰
分子量	206.28	别名	N-hydroxy-N'-(4-n-butyl-2-methylphenyl)Formamidine

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