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CAS No.: 141-94-6

Hexetidine Catalog No. CSN11149

Synonyms: NSC-17764

Hexetidine is an anti-bacterial and anti-fungal agent commonly used in both veterinary and human medicine, is a local anesthetic.

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技术信息

生物活性

描述Hexetidine is very safe oral antiseptic with broad antibacterial and antifungal activity in vivo and in vitro. It has local-anesthetics, astringent and deodorant activity. Also, it has very strong antiplac effects. Resistention of microorganisms on hexetidine is short and transient^[3]. Increasing the concentration of hexetidine from 1% to 10% (w/w) (but not from 10% to 20% w/w) increased the subsequent rate of drug release. The resistance of hexetidine-containing PVC (1% or 5%) to microbial adherence (following defined periods of drug release) was greater than that of native PVC (hexetidine-impregnated poly(vinyl chloride)) and was constant over the examined period of hexetidine release^[4]. In addition, reduction in the number of colony-forming units (CFU) of C. albicans after immersion of the dentures with hexetidine 0.1% was evaluated compared to those of the control group. Hexetidine 0.1% solution tested for the first time as a product of disinfection of the acrylic dentures showed average results after immersion of 8 night hours for 4 days^[5].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT02150031	Bacteremia To... more >>oth Extraction Status Nos Collapse <<	Phase 4	Completed	-	Portugal ... more >> Department of Stomatology and Maxillofacial Surgery of the Santo Antonio General Hospital Oporto, Portugal, 4099-001 PORTO Spain Department of Stomatology University of Santiago de Compostela Santiago de Compostela, Galicia/A Coruña, Spain, 15782 Collapse <<
NCT02115776	Bacteremia	Not Applicable	Completed	-	Spain ... more >> Hospital Clinico Universitario de Santiago Santiago de Compostela, A Coruña, Spain, 15782 Santiago de Compostela University Hospital Santiago de Compostela, Coruña, Spain, 15782 Collapse <<
NCT02124655	Oral Biofilm ... more >>Mouthwash Periodontitis Collapse <<	Phase 4	Completed	-	Spain ... more >> Faculty of Medicine and Dentistry of the University of Santiago de Compostela Santiago de Compostela, A Coruña, Spain, 15782 Collapse <<

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参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.9446 mL
- 14.7231 mL
- 29.4462 mL
- 5 mM
- 0.5889 mL
- 2.9446 mL
- 5.8892 mL
- 10 mM
- 0.2945 mL
- 1.4723 mL
- 2.9446 mL

技术信息

CAS号

141-94-6

储存条件

粉末: Keep in dark place,Sealed in dry,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C21H45N3

运输

蓝冰

分子量

339.60

别名

NSC-17764

溶解度

DMSO	98.0 mg/mL (288.6 mM)

动物实验配方

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