CAS No.: 41137-87-5
Hirsutenone Catalog No. CSN14412
Synonyms: Hirsutanone
Hirsutenone, a natural product isolated and purified from the eaves of Alnus nepalensis, exhibits anti-cancer effect against prostate cancer through a direct physical inhibition of Akt1/2, attenuates adipogenesis by directly targeting PI3K and ERK during MCE in 3T3-L1 preadipocytes, underscoring the potential therapeutic application of Hirsutenone in preventing obesity, and may exert a preventive effect against microbial endotoxin lipopolysaccharide-induced inflammatory skin diseases through inhibition of ERK pathway-mediated NF-kappaB activation. Hirsutenone showed potent PL(pro) inhibitory activity with IC50 value of 4.1µM.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 参考文献
- [1] Seo GS, Jiang WY, et al. Hirsutenone reduces deterioration of tight junction proteins through EGFR/Akt and ERK1/2 pathway both converging to HO-1 induction. Biochem Pharmacol. 2014 Jul 15;90(2):115-25.
- [2] Farrand L, Kim JY, et al. The diarylheptanoid hirsutenone sensitizes chemoresistant ovarian cancer cells to cisplatin via modulation of apoptosis-inducing factor and X-linked inhibitor of apoptosis. J Biol Chem. 2014 Jan 17;289(3):1723-31.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 41137-87-5 | 储存条件 |
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| 分子式 | C19H20O5 | 运输 | 蓝冰 | |
| 分子量 | 328.36 | 别名 | Hirsutanone |
