|3,4,5-三羟基-2-((E)-3-(4-羟基苯基)丙烯酰基)-4-((2R,3R,4S,5S,6R)-3,4,5-三羟基-6- (羟甲基)四氢-2H-吡喃-2-基)-6-((2S,3R,4R,5S,6R)-3,4,5-三羟基-6-(羟甲基)四氢-2H-吡喃-2- 基)环己烷-2,5-二烯酮|CsnPharm

CAS No.: 78281-02-4

Hydroxysafflor yellow A/羟基红花黄色素A Catalog No. CSN11176

Synonyms: Safflomin A;HSYA;Hydroxysafflor Yellow A

Hydroxysafflor yellow A is a flavonoid derived and isolated from traditional Chinese medicine Carthamus tinctorius L., possessing anti-tumor activity.

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400-920-2911

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技术信息

生物活性

描述Hydroxysafflor yellow A (HSYA) is a flavonoid derived and isolated from traditional Chinese medicine Carthamus tinctorius L., possessing anti-tumor activity. It can suppress foam cell formation, vascular endothelial cell dysfunction, vascular smooth muscle cell proliferation and migration, and platelet activation. Besides, HSYA is devoted to lowering blood lipids, regulating ion channels, reducing vascular inflammation, and protecting pancreatic beta cells^[3]. HYSA could inhibit LPS-induced VSMCs proliferation and migration, accompanied by the downregulated levels of several key pro-inflammatory cytokines, including TNF-α, IL-6, and IL-8. HYSA inhibited LPS-induced upregulation of TLR-4 expression as well as the activation of Rac1/Akt pathway^[4]. HSYA (14, 28, 56 mg/kg, i.p.) has a protective effect on acute respiratory distress syndrome (ARDS) induced by LPS through blocking the TLR4/NF-κB pathway, and that the TLR4 receptor might be a target of HSYA on the cell membrane^[5]. 8 mg/kg and 16 mg/kg HSYA administration by common carotid artery (CCA) injection improved impaired cognitive function in Morris water maze (MWM) and passive avoidance tasks. And 8 mg/kg HSYA treatment rescued the impaired long-term potentiation (LTP) in hippocampus of MCAO (middle cerebral artery occlusion) rats^[6].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.6326 mL
- 8.1628 mL
- 16.3256 mL
- 5 mM
- 0.3265 mL
- 1.6326 mL
- 3.2651 mL
- 10 mM
- 0.1633 mL
- 0.8163 mL
- 1.6326 mL

技术信息

CAS号	78281-02-4	储存条件	粉末 Sealed in dry,2-8°C 液体 -20°C:3-6 月 -80°C:12月
分子式	C27H32O16	运输	蓝冰
分子量	612.53	别名	Safflomin A;HSYA;Hydroxysafflor Yellow A;羟基红花黄色素A

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