CAS No.: 1807523-99-4
IACS-010759 HCl Catalog No. CSN26721
Synonyms: IACS-10759 hydrochloride;IACS-010759 HCl;IACS-10759
IACS-010759 or IACS-10759 is a potent inhibitor of complex I of OXPHOS. IACS-10759 effectively inhibits ATP production and oxygen consumption in isolated mitochondria, and inhibits the conversion of NADH to NAD+ in immunoprecipitated complex I in low nM range. IACS-10759 is orally bioavailable with excellent physicochemical properties in preclinical species, and shows significant efficacy in multiple tumor indications both in vitro and in vivo. IACS-10759 causes robust tumor regression, but has no effect in the same model when glycolysis is restored.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 1807523-99-4 | 储存条件 |
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| 分子式 | C25H26ClF3N6O4S | 运输 | 蓝冰 | |
| 分子量 | 599.03 | 别名 | IACS-10759 hydrochloride;IACS-010759 HCl;IACS-10759;IACS-010759 |
