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CAS No.: 36945-98-9

Icilin Catalog No. CSN16140

Synonyms: AG-3-5;AG 3-5 cpd;BRN 0700310

Icilin is an agonist of TRPM8 ion channel with EC50 of 0.36 μM in HEK 293 cells.

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靶点选择性

生物活性

实验方案

技术信息

生物活性

描述Icilin is an agonist of nonselective cation channel TRPM8, with antiproliferative activity. TRPM8 is a cation channel activated by cold temperatures and the chemical stimuli menthol and icilin^[3]. The synthetic supercooling drug, icilin, and its primary receptor target, the cation channel transient receptor potential (TRP) melastatin-8 (TRPM8), have been described as potent negative regulators of inflammation in the colon. In vitro, icilin potently inhibited the proliferation of murine and human CD4+ T cells, with the peripheral expansion of autoantigen-restricted T cells similarly diminished by the administration of icilin in mice^[4]. Rats injected with icilin (0.5, 1, 2.5, 5mg/kg, i.p.) displayed dose-related WDS (wet-dog shakes) that were inhibited by pretreatment with a fixed dose of clonidine (0.15 mg/kg, s.c.). alpha(2)-adrenoceptor activation inhibits shaking induced by icilin and that increases in peripheral, as well as central, alpha(2)-adrenoceptor signaling oppose the behavioral stimulant effect of icilin^[5].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.2124 mL
- 16.0621 mL
- 32.1242 mL
- 5 mM
- 0.6425 mL
- 3.2124 mL
- 6.4248 mL
- 10 mM
- 0.3212 mL
- 1.6062 mL
- 3.2124 mL

技术信息

CAS号

36945-98-9

储存条件

粉末: Inert atmosphere,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C16H13N3O4

运输

蓝冰

分子量

311.29

别名

AG-3-5;AG 3-5 cpd;BRN 0700310

溶解度

DMSO	53.0 mg/mL (170.3 mM)
Water	Insoluble

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Icilin Catalog No. CSN16140

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