|1,1'-亚甲基双(3-(3-(羟甲基)-2,5-二氧代咪唑啉-4-基)脲)|CsnPharm

CAS No.: 39236-46-9

Imidazolidinyl Urea/咪唑烷基脲 Catalog No. CSN11194

Synonyms: Imidurea;咪唑烷基脲

Imidazolidinyl Urea is one of the most widely used preservative systems in the world and is commonly found in cosmetics as an antimicrobial preservative.

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技术信息

生物活性

描述Imidazolidinyl urea is an antimicrobial preservative used in cosmetics, acts as a formaldehyde releaser^[2]. Imidazolidinyl urea at high concentrations can induce neural toxicity in rat brains through ROS (reactive oxygen species) induction and apoptosis^[3]. Preservative treatment resulted in a dose-dependent decrease of cell viability. IMU (Imidazolidinyl urea) and EGPE (2-phenoxyethanol) required higher concentrations to induce apoptosis (IMU 0. 01-0. 1% and EGPE (0.01-0. 5%) or necrosis (IMU 0. 5-1% and EGPE only at 1%)^[4]. The expression level of inflammation-related proteins such as IL-1 beta were increased in imidazolidinyl urea-treated cells. The CV (cyclic voltammetry) results demonstrated that imidazolidinyl urea significantly reduced the current peaks in a dose-dependent manner^[5].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT00795951	Dermatitis, Contact	Phase 4	Completed	-	United States, California ... more >> Rady Children's Hospital San Diego, California, United States, 92123 Collapse <<
NCT00795951	-	-	Completed	-	-
NCT03700580	Diabetic Foot ... more >> Neuropathy, Diabetic Foot Ulcer Collapse <<	Phase 2	Completed	-	Brazil ... more >> Unidade de Referência Secundária (URS) Padre Eustáquio, do Distrito Sanitário Noroeste da Secretaria Municipal e Saúde de Belo Horizonte. Belo Horizonte, Minas Gerais, Brazil, 30720-100 Collapse <<

参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.5754 mL
- 12.8770 mL
- 25.7539 mL
- 5 mM
- 0.5151 mL
- 2.5754 mL
- 5.1508 mL
- 10 mM
- 0.2575 mL
- 1.2877 mL
- 2.5754 mL

技术信息

CAS号

39236-46-9

储存条件

粉末: Keep in dark place,Inert atmosphere,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C11H16N8O8

运输

蓝冰

分子量

388.29

别名

Imidurea;咪唑烷基脲

溶解度

DMSO	76.0 mg/mL (195.7 mM)

动物实验配方

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