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CAS No.: 36703-88-5

Inosine Pranobex/异丙肌苷 Catalog No. CSN23247

Synonyms: Imunovir;Delimmun;Groprinosin

Isoprinosine is a nucleoside, an alkylamino-alcohol complex of inosine used in the treatment of a variety of viral infections.

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实验方案

技术信息

生物活性

描述Isoprinosine (Inos) or immunovir is a synthetic purine derivative with immune-modulatory and antiviral properties. The drug shows apparent in vivo enhancement of host immune responses by inducing pro-inflammatory cytokines and rapid proliferation of T-cell subsets^[1]. Low doses, 50 microgram/kg to 50 mg/kg, significantly increased the numbers of IgM- or IgG-spleen antibody-forming cells. Large doses, such as the LD50 (5 g/kg) or pretreatments where unable to impair mouse immune responsiveness. Isoprinosine (< 500 mg/kg/day) orally administered at time of or one day after immunization stimulated immune responses^[2]. In vitro isoprinosine strongly increased T-cell mitogenesis in spleen cells from normal rats, with only modest increases in B-cell mitogenesis and no effects on unstimulated cells. In vivo isoprinosine (50 mg kg-1 day-1 orally) had no effects on spleen cell responsiveness when administered to normal rats for 4 or 14 days. In rats with adjuvant arthritis treated with isoprinosine for 14 days, depressed T-cell responsiveness was completely restored to the level of the nonarthritic animals. T-suppressor cell function, impaired in arthritic rats, was not restored by treatment with isoprinosine^[3].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT00000699	HIV Infections	Phase 1	Completed	-	United States, District of Col... more >>umbia George Washington Univ Med Ctr Washington, District of Columbia, United States, 20037 Collapse <<
NCT00002295	HIV Infections	Not Applicable	Completed	-	United States, California ... more >> Newport Pharmaceuticals International Inc Laguna Hills, California, United States, 92656 Collapse <<
NCT00002061	Lymphatic Disease ... more >> HIV Infections Collapse <<	Not Applicable	Completed	-	United States, California ... more >> Newport Pharmaceuticals International Inc Laguna Hills, California, United States, 92656 Collapse <<

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参考文献

[1] Mishra AK, Yabaji SM, Dubey RK. Evaluation of isoprinosine to be repurposed as an adjunct anti-tuberculosis chemotherapy. Med Hypotheses. 2018 Jun;115:77-80
[2] Renoux G, Renoux M, Guillaumin JM. Isoprinosine as an immunopotentiator. J Immunopharmacol. 1979;1(3):337-56
[3] Binderup L. Effects of isoprinosine in animal models of depressed T-cell function. Int J Immunopharmacol. 1985;7(1):93-101

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 0.8967 mL
- 4.4834 mL
- 8.9667 mL
- 5 mM
- 0.1793 mL
- 0.8967 mL
- 1.7933 mL
- 10 mM
- 0.0897 mL
- 0.4483 mL
- 0.8967 mL

技术信息

CAS号

36703-88-5

储存条件

粉末: Inert atmosphere,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C52H78N10O17

运输

蓝冰

分子量

1115.23

别名

Imunovir;Delimmun;Groprinosin;Isoprinosine;NPT 10381;NP-113

溶解度

DMSO	98.0 mg/mL (87.9 mM)
Ethanol	2.0 mg/mL (1.8 mM)

动物实验配方

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