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CAS No.: 54-92-2

Iproniazid/异丙烟肼 Catalog No. CSN23617

Synonyms: Marsilid;Iprazid;N'-Isopropylisonicotinohydrazide

Iproniazid is an irreversible non-selective MAO inhibitor.

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技术信息

生物活性

描述Iproniazid is a non-selective, irreversible monoamine oxidase (MAO) inhibitor of the hydrazine class. Iproniazid has antidepressive activity^[1]. Iproniazid, which inhibits monoamine oxidase but not prostacyclin synthesis, failed to enhance platelet aggregation^[2]. Iproniazid was found to inhibit formalin-induced oedema of the foot, dextran-induced oedema and cotton-pellet-induced granulomatous tissue in the rat^[3]. 5-Hydroxytryptamine can interrupt pregnancy at all stages in mice but is particularly effective early and late in pregnancy. Iproniazid exerts its action essentially in the first half of pregnancy. 5-Hydroxytryptamine produces striking hemorrhage in the placenta^[4]. Chronic glucocorticoid treatment may have a slight inhibitory effect on brain MAO and also has the ability to partially reverse or antagonize the inhibition of MAO caused by iproniazid^[5]. Rats were bilaterally ovariectomized on Day 3 post coitum and treated daily with progesterone. Iproniazid, an inhibitor of monoamine oxidase, on Day 8 induced implantation in all rats^[6].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 5.5797 mL
- 27.8987 mL
- 55.7973 mL
- 5 mM
- 1.1159 mL
- 5.5797 mL
- 11.1595 mL
- 10 mM
- 0.5580 mL
- 2.7899 mL
- 5.5797 mL

技术信息

CAS号

54-92-2

储存条件

粉末: Keep in dark place,Inert atmosphere,Room temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C9H13N3O

运输

蓝冰

分子量

179.22

别名

Marsilid;Iprazid;N'-Isopropylisonicotinohydrazide;异丙烟肼

溶解度

DMSO	33.0 mg/mL (184.1 mM)
Water	34.0 mg/mL (189.7 mM)
Ethanol	35.0 mg/mL (195.3 mM)

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