|(1S,3R,4R,5R)-3,4-双(((E)-3-(3,4-二羟基苯基)丙烯酰)氧基)-1,5-二羟基环己烷甲酸|CsnPharm

CAS No.: 14534-61-3

Isochlorogenic acid B/异绿原酸B Catalog No. CSN19329

Synonyms: 3,4-Di-O-caffeoylquinic acid;Isochlorogenic acid B;3,4-Dicaffeoylquinic Acid

3,4-Dicaffeoylquinic Acid is a polyphenol with diverse biological activities, it inhibits acetylcholinesterase (ACE) and α-glucosidase in a concentration-dependent manner, shows cytotoxic to NCI-H23 lung adenocarcinoma cells, as well as increases tumor necrosis factor-related apoptosis inducing ligand (TRAIL) mRNA, reduces influenza H1N1 hemagglutinin (HA) mRNA and increases survival in a mouse model of influenza A infection.

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技术信息

生物活性

描述Isochlorogenic acid B (ICAB), naturally isolated from Laggera alata, and has antioxidative and hepatoprotective properties. ICAB significantly improved the pathological lesions of liver fibrosis. ICAB had a significant protective effect on fibrosis in NASH (non-alcoholic steatohepatitis) by inhibiting oxidative stress via Nrf2 and suppressing multiple profibrogenic factors through miR-122/HIF-1α signalling pathway^[3]. Isochlorogenic Acid B (3,4-Dicaffeoylquinic Acid) is a polyphenol with diverse biological activities, it inhibits acetylcholinesterase (ACE) and α-glucosidase in a concentration-dependent manner, shows cytotoxic to NCI-H23 lung adenocarcinoma cells (EC50 3.26 μg/ml), as well as increases tumor necrosis factor-related apoptosis inducing ligand (TRAIL) mRNA, reduces influenza H1N1 hemagglutinin (HA) mRNA and increases survival in a mouse model of influenza A infection. 3,4-Dicaffeoylquinic acid also displays a concentration-dependent α-glucosidase inhibition with EC50 241.80 μg/ml^[4]. ITPL contained the following seven compounds: neochlorogenic acid, cryptochlorogenic acid, rutin, kaempferin, isochlorogenic acid B, isochlorogenic acid A, and hesperidin. The pathological observations show that ITPL reduced the oxidative damage of the liver and spleen in mice induced with D-galactose. ITPL had beneficial preventive effects on the oxidative damage caused by D-galactose in mice and was more effective as an antioxidant than vitamin C^[5].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.9363 mL
- 9.6815 mL
- 19.3630 mL
- 5 mM
- 0.3873 mL
- 1.9363 mL
- 3.8726 mL
- 10 mM
- 0.1936 mL
- 0.9681 mL
- 1.9363 mL

技术信息

CAS号

14534-61-3

储存条件

粉末: Sealed in dry,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C25H24O12

运输

蓝冰

分子量

516.45

别名

3,4-Di-O-caffeoylquinic acid;Isochlorogenic acid B;3,4-Dicaffeoylquinic Acid;3,4-DCQA;异绿原酸B

溶解度

DMSO	50.0 mg/mL (96.8 mM) warming

动物实验配方

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Isochlorogenic acid B/异绿原酸B Catalog No. CSN19329

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