|3-甲基丁酰胺|CsnPharm

CAS No.: 541-46-8

Isovaleramide/3-甲基丁酰胺 Catalog No. CSN11234

Synonyms: 3-Methylbutanamide;NPS-1776;异戊酰胺

Isovaleramide, a liver alcohol dehydrogenases inhibitor, is an anticonvulsant molecule isolated from Valeriana pavonii.

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技术信息

生物活性

描述Isovaleramide is an active principle on central nervous system from Valeriana pavonii, as an anticonvulsant. Isovaleramide at 100 mg/kg, p.o, evidenced a 90% index protection against the maximal electroshock seizure in mice (MES), comparable to the reference agent: sodium phenytoin (20 mg/kg, p.o, 100%). In the in vitro assay, isovaleramide (300 µM) exhibited a 42% of inhibition of the binding of ³H-FNZ to its sites^[3]. Isovaleramide, was essentially uncompetitive inhibitors of purified horse and rat liver alcohol dehydrogenases with respect to ethanol as substrate. The uncompetitive inhibition constants for isovaleramide for rat liver alcohol dehydrogenase was 20 mM, in vitro, whereas in vivo the values was 180 mumol/kg^[4].
参考文献

[1] Giraldo SE, Rincon J, et al. [Isovaleramide, an anticonvulsant molecule isolated from Valeriana pavonii] .Biomedica. 2010 Apr-Jun;30(2):245-50. Spanish.
[2] Bialer M, Johannessen SI, et al. Progress report on new antiepileptic drugs: a summary of the Seventh Eilat Conference (EILAT VII). Epilepsy Res. 2004 Sep-Oct;61(1-3):1-48.
[3] Giraldo SE, Rincón J, Puebla P, Marder M, Wasowski C, Vergel N, Guerrero MF. Isovaleramida, principio anticonvulsivo aislado de Valeriana pavonii [Isovaleramide, an anticonvulsant molecule isolated from Valeriana pavonii]. Biomedica. 2010 Apr-Jun;30(2):245-50. Spanish
[4] Chadha VK, Leidal KG, Plapp BV. Inhibition by carboxamides and sulfoxides of liver alcohol dehydrogenase and ethanol metabolism. J Med Chem. 1983 Jun;26(6):916-22

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 9.8866 mL
- 49.4331 mL
- 98.8661 mL
- 5 mM
- 1.9773 mL
- 9.8866 mL
- 19.7732 mL
- 10 mM
- 0.9887 mL
- 4.9433 mL
- 9.8866 mL

技术信息

CAS号

541-46-8

储存条件

粉末: Sealed in dry,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C5H11NO

运输

蓝冰

分子量

101.15

别名

3-Methylbutanamide;NPS-1776;异戊酰胺

溶解度

DMSO	225.0 mg/mL (2224.5 mM)
Water	200.0 mg/mL (1977.3 mM) warming

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